Metal injection molding (MIM) is an advanced manufacturing technology that enables the mass production of high-performance and complex materials, such as the Ti-6Al-4V alloy. The determination of the size change and deformation of the Ti-6Al-4V alloy after the sintering process is challenging and critical for quality control. The numerical simulation could be a fast and cost-effective way to predict size change and deformation, given the large degrees of freedom for the sintering process. Herein, a finite element method based on the thermal-elastic-viscoplastic macroscopic model is developed to predict the shrinkage, deformation, relative density, and crack of injection-molded Ti-6Al-4V after sintering, using the Simufact software. Excellent agreements between experimental measurements and numerical simulations of the size and deformation are demonstrated (within a 3% error), confirming the accuracy of the numerical model. This approach can serve as a guideline for the mold design and sintering optimization of the MIM process.