The Investigation of Total PSA, Free PSA, and Free/Total PSA Ratio in Patients With Liver Cirrhosis Patients According to Child-Pugh Score

Ursodeoxycholic acid alleviates cholestasis-induced histophysiological alterations in the male reproductive system of bile duct-ligated rats

“…The present study revealed that BDL rats had smaller prostate glands and lower serum PSA levels in comparison to sham ones. In agreement with our results, patients with liver cirrhosis have decreased PSA levels in comparison to healthy subjects [49,51]. Low PSA levels accompanied by liver cirrhosis have been attributed to shrunken prostatic volume, decreased testosterone levels, or diminished serum protein level as a result of liver dysfunction [49].…”

“…PSA is a serine protease produced from the prostate gland under androgenic control, and has been postulated as an effective predictor of prostate volume [49], a marker of testestoterone concentrations, and a valuable tool in confirming hypogonadism [50]. The present study revealed that BDL rats had smaller prostate glands and lower serum PSA levels in comparison to sham ones.…”

The likelihood of having a serum PSA level of ≥2.5 ng/mL according to the degree of fatty liver disease in a screened population

“…17,18 Rather, results revealing no or negative relation between liver disease and serum PSA were predominant. [19][20][21][22][23][24] Some investigators noted that serum PSA levels were not significantly different between healthy men and men with liver cirrhosis or chronic hepatitis. 17,18 Williams et al found that serum bilirubin and aminotransferases declined significantly after liver transplantation, but the mean serum PSA levels before and after liver transplantation were not different.…”

“…Inci et al suggested that the production of PSA in patients with severe liver disease might be affected by three mechanisms. 21 First, liver disease results in decreased It would be interesting to know the sex hormone level in patients with FLD compared to those with liver cirrhosis. Recently, observational studies have showed that a low serum total testosterone level is independently associated with nonalcoholic FLD, regardless of visceral adipose tissue and insulin resistance, similarly with liver cirrhosis.…”

Urologische Aspekte bei Patienten mit Leberzirrhose

“…Die niedrigsten tPSA-Werte haben Patienten mit schlechterer Leberfunktion (Child-Pugh C) und mit geringeren Testosteronlevels [25]. Überdies sind ein vermindertes Prostatavolumen, ein reduziertes allgemeines Serumprotein und die Tatsache der hormonellen Funktionsstö-rung in der Hypothalamus-HypophysenHoden-Achse dafür verantwortlich [26]. Die digitale Untersuchung sollte bei LZPatienten auch bei scheinbar normalen PSA-Werten regelmäßig durchgeführt werden.…”