The Investigation on the Effect of the Vegetal Origin Ankaferd Blood Stopper in Experimental Intra-Abdominal Surgery Over Rabbits

Düz, Erkan; Aslan, Loğman; Alkan, İsmail; Bayram, İrfan; Kaya, Abdullah; Ayhan, Harun; Özer, Eda Özturan

doi:10.3923/javaa.2010.1491.1494

Cited by 3 publications

(2 citation statements)

References 15 publications

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“…This is even more true when the cut is deep, probably because the blood volume charged at this time is important. The effect of the sap of J. multifida on bleeding time is comparable to Ankaferd Blood Stopper, a mixture of traditional plants (Thymus vulgaris, Glycyrrhiza glabra, Vitis vinifera, Alpinia officinarum, and Urtica dioica) acting on hemostasis reducing bleeding time (Duz et al, 2010).…”

Section: Discussionmentioning

confidence: 90%

Evaluation of the phytochemical and hemostatic potential of Jatropha multifida sap

Dougnon¹

2012

Afr. J. Pharm. Pharmacol.

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Jatropha multifida is a plant traditionally recognized for its medicinal properties. This study was undertaken not only to assess the hemostatic potential of the sap of J. multifida, but also to elucidate its chemical profile. Wistar rats were injured at various locations and time of bleeding was evaluated based on the addition of J. multifida's sap or distilled water. Phytochemical study was performed on sap. J. multifida's sap significantly reduced bleeding time. Indeed, more blood flow was noticed on the side that received physiological water than the one which received the sap. This is even truer when the cut is deep with times of bleeding reduction of 39.06, 47.89, and 46.68%, respectively for superficial wounds, saphenous vein, and the femoral vein clippings. The phytochemical screening of J. multifida showed the presence of tannins, flavonoids, saponins, leucoanthocyanes, mucilage and reducing compounds. The power of the hemostatic sap is explained by the strong presence of tannins and flavonoids. All this proves that using the sap of J. multifida in traditional medicine is justified.

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Section: Discussionmentioning

confidence: 90%

Evaluation of the phytochemical and hemostatic potential of Jatropha multifida sap

Dougnon¹

2012

Afr. J. Pharm. Pharmacol.

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“…The effect of SJM on TS is similar to that of Ankaferd Blood Stopper, a mixture of traditional plants (Thymus vulgaris, Glycyrrhiza glabra, Vitis vinifera, Alpinia officinarum and Urtica NaCl SJM dioica) which acts on haemostasis by reducing bleeding time [22], [23]. This mix of five plants therefore has the same effect as the only LSU; Which constitutes an additional advantage offered by this plant.…”

Section: Discussionmentioning

confidence: 51%

Hemostatic Effect of Jatropha multifida L. (Euphorbiaceae) in Rats Having Coagulation Disorders

2017

J App Biol Biotech

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Jatropha multifida is a plant whose sap is used in traditional Beninese medicine as haemostatic. Previous work has shown are efficiencies in rapidly causing blood clotting and stopping bleeding in normal rats. The aim of this study was to investigate the haemostatic effects of J. multifida sap (SJM) on rats with coagulation disorders. In vivo haemostatic tests were performed on 14 Wistar albino rats including 7 normal rats and 7 warfarin-treated rats (2mg / kg orally for 4 days). After ketamine anesthesia (80 mg / kg) intramuscularly and local application of 2% xylocaine (10 mg / kg); Superficial cuts, saphenous vein and femoral vein were performed simultaneously on the two hind legs of each rat. SJM was applied locally on one of the legs and placebo (0.9% NaCl) on the other. Bleeding Times (TS) were recorded in each case. In normal rats, the results obtained indicated that the SJM topical application significantly reduced TS regardless of the type of cut. Reduction percentages were 39.06%, 46.68% and 47.89%, respectively, with superficial cuts, saphenous vein and femoral vein. In rats pretreated with warfarin, the TS reduction percentages were 71.52%, 61.54% and 66.44%, respectively, with superficial cuts, saphenous vein and femoral vein. The application of SJM significantly decreased TS compared to placebo. SJM has been shown to be effective in stopping hemorrhage in normal rats and those with coagulation disorders.

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Topical hemostatic agents: a systematic review with particular emphasis on endoscopic application in GI bleeding

Barkun

Moosavi

Martel

2013

Gastrointestinal Endoscopy

124

106

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The Investigation on the Effect of the Vegetal Origin Ankaferd Blood Stopper in Experimental Intra-Abdominal Surgery Over Rabbits

Cited by 3 publications

References 15 publications

Evaluation of the phytochemical and hemostatic potential of Jatropha multifida sap

Evaluation of the phytochemical and hemostatic potential of Jatropha multifida sap

Hemostatic Effect of Jatropha multifida L. (Euphorbiaceae) in Rats Having Coagulation Disorders

Topical hemostatic agents: a systematic review with particular emphasis on endoscopic application in GI bleeding

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