The Involvement of Angiotensin Type 1 and Type 2 Receptors in Estrogen-Induced Cell Proliferation and Vascular Endothelial Growth Factor Expression in the Rat Anterior Pituitary

Ławnicka, Hanna; Ptasinska-Wnuk, Dorota; Mucha, S; Kunert‐Radek, Jolanta; Pawlikowski, Marek; Stępień, H

doi:10.1100/2012/358102

Cited by 4 publications

(5 citation statements)

References 64 publications

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“…On the other hand, Lawnicka et al noticed that stimulation of proliferation in rat anterior pituitary by diethylstilboestrol (DES), synthetic estrogen, was inhibited by losartan (AT1R antagonist), PD123319 (AT2R antagonist), and captopril (ACE inhibitor). This result was evidence of AT1R and AT2R involvement in estrogen-dependent mitogenic effect in rat pituitary [54]. Surprisingly, the research carried out by Ptasinska-Wnuk et al revealed anti-proliferative consequence of angiotensins [Ang II, Ang IV, angiotensin 5-8 (Ang 5-8)] on GH3 lactosomatotroph pituitary tumor cell culture.…”

Section: Pituitary Glandmentioning

confidence: 89%

“…Many studies revealed correlation between angiotensin and proliferation of pituitary gland cells [ 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 ]. Moreover, Ang II was observed to induce proliferation of mouse spleen lymphocytes in vitro.…”

Section: Pituitary Glandmentioning

confidence: 99%

“…They observed that all aforementioned peptides increased VEGF concentration in GH3 cells and rat adenoma cells. Moreover, this effect was mediated by ATRs in GH3 culture, while the stimulatory effect on VEGF by Ang II was decreased by administration of AT1R and AT2R antagonists, losartan and PD123319, respectively [ 54 , 190 ]. Similar effect was noticed by Lawnicka et al in the rat anterior pituitary.…”

Section: Angiogenesismentioning

confidence: 99%

“…Treatment with DES caused elevated VEGF reactivity in blood vessels and anterior pituitary cells. Addition of AT1R and AT2R antagonists and ACE inhibitor caused diminished the number of VEGF-positive blood vessels [ 54 ]. Those outcomes suggested that RAS takes part in stimulation of angiogenesis by induction of VEGF secretion acting by AT1R and AT2R in estrogen-induced adenoma [ 56 ].…”

Section: Angiogenesismentioning

confidence: 99%

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Angiotensin II and Angiotensin Receptors 1 and 2—Multifunctional System in Cells Biology, What Do We Know?

Ziaja

Urbanek

Kowalska

et al. 2021

Cells

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For years, the renin-angiotensin system (RAS) has been perceived as a system whose role is to primarily modulate the functioning of the cardiovascular system. Years of research into the role of RAS have provided the necessary data to confirm that the role of RAS is very complex and not limited to the cardiovascular system. The presence of individual elements of the renin-angiotensin (RA) system allows to control many processes, ranging from the memorization to pro-cancer processes. Maintaining the proportions between the individual axes of the RA system allows for achieving a balance, often called homeostasis. Thus, any disturbance in the expression or activity of individual RAS elements leads to pathophysiological processes.

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Section: Pituitary Glandmentioning

confidence: 89%

Section: Pituitary Glandmentioning

confidence: 99%

Section: Angiogenesismentioning

confidence: 99%

Section: Angiogenesismentioning

confidence: 99%

See 2 more Smart Citations

Angiotensin II and Angiotensin Receptors 1 and 2—Multifunctional System in Cells Biology, What Do We Know?

Ziaja

Urbanek

Kowalska

et al. 2021

Cells

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show abstract

“…** P<0.01 compared with Control group and Telmisartan group(one-way ANOVA). [20][21][22]. Besides, angiogenesis might be another reason.…”

Section: Pulmonary Arterial Wall Thickness and Elastic Fibersmentioning

confidence: 99%

Telmisartan Protect Broiler Chickens from Pulmonary Arterial Remodeling Induced by Low Ambient Temperature

Cheng¹

2014

J Clin Exp Cardiolog

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Objective: Renin-angiotensin system is associated with many vascular diseases. This study aims to explore the protective effect of telmisartan, Angiotensin type 1 receptor blocker, on pulmonary arterial remodeling induced by low ambient temperature in broiler chickens. Methods: Ninety chickens were randomly divided into 3 groups (n=30), including control group, low temperature group and telmisartan group. Chickens in low temperature group and telmisartan group were exposed to low ambient temperature from 14 days of age until 45 days of age; chickens in telmisartan group were gavaged with telmisartan 5 mg/kg once daily for thirty days. The pulmonary arterial systolic pressure was measured with right catheterization method. Wet lung weight index and right ventricular hypertrophy index were evaluated. Small pulmonary artery wall thickness and elastic fibers was determined respectively by HE staining and Weight staining. Proliferating Cell Nuclear Antigen (PCNA)-positive cells were determined by Immunohistochemical staining. Results: It showed that pulmonary arterial systolic pressure, wet lung weight index and right ventricular hypertrophy index, small pulmonary artery wall thickness, elastic fibers and PCNA expression increased significantly in Low temperature group compared with control group and telmisartan group. Conclusion: Telmisartan can protect broiler chickens from pulmonary arterial remodeling induced by low ambient temperature

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Variations in the adenohypophysis of the expression of proliferating cellular nuclear antigen, oestrogen and androgen receptors in relation to gonadal steroids during pregnancy of viscachas (Lagostomus maximus maximus)

Rosales

Perez

Rodríguez

et al. 2019

Reprod. Fertil. Dev.

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Viscachas are native rodents of South America that present a long pregnancy of ~154 days. In this work, we analysed variations in the expression of proliferating cellular nuclear antigen, oestrogen and androgen receptors (ERα and AR) in pituitary pars distalis (PD) and pars tuberalis (PT) in relation to oestradiol and testosterone serum levels in non-pregnant and pregnant viscachas. In PD, cell proliferation increased with pregnancy and lactotrophs proliferated during mid-pregnancy (MP). ERα nuclear-immunoreactive cells (ERαn-ir) were maximal in late pregnancy and AR expression did not vary during pregnancy. In PT, cell proliferation and AR expression increased during pregnancy, but ERα expression was very scarce. The immunostaining pattern of receptors was different in PD and PT. The peak of serum oestradiol and testosterone occurred during MP. Our results suggest that cell proliferation and gonadal receptors might be differentially regulated in the pituitary by oestradiol and testosterone during viscacha pregnancy.

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The Involvement of Angiotensin Type 1 and Type 2 Receptors in Estrogen-Induced Cell Proliferation and Vascular Endothelial Growth Factor Expression in the Rat Anterior Pituitary

Cited by 4 publications

References 64 publications

Angiotensin II and Angiotensin Receptors 1 and 2—Multifunctional System in Cells Biology, What Do We Know?

Angiotensin II and Angiotensin Receptors 1 and 2—Multifunctional System in Cells Biology, What Do We Know?

Telmisartan Protect Broiler Chickens from Pulmonary Arterial Remodeling Induced by Low Ambient Temperature

Variations in the adenohypophysis of the expression of proliferating cellular nuclear antigen, oestrogen and androgen receptors in relation to gonadal steroids during pregnancy of viscachas (Lagostomus maximus maximus)

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