The involvement of dopamine in nociception: the role of D1 and D2 receptors in the dorsolateral striatum

A New Scenario for Negative Functional Magnetic Resonance Imaging Signals: Endogenous Neurotransmission

“…Furthermore, the infusion of D2DR agonists and antagonists reduced and augmented nociception, respectively. In contrast, no changes in pain-related behavior were observed following up-regulation or down-regulation of dopamine D1 receptor (D1DR) activity (Magnusson and Fisher, 2000). These findings suggest that striatal neurons expressing D2DRs are major players in antinociceptive effects on pain modulation.…”

“…We hypothesized that endogenous dopaminergic neurotransmission can lead to these confounding effects since the dopamine D 2 receptor (D2DR) has been proposed as being involved in regulating both pain behaviors (Magnusson and Fisher, 2000;Mansikka et al, 2005) and vascular responses (Choi et al, 2006). It has also been suggested that D2DR availability is positively correlated with the response to pain in both healthy subjects Scott et al, 2006) and patients with chronic pain syndrome .…”

Variations in the Human Pain Stress Experience Mediated by Ventral and Dorsal Basal Ganglia Dopamine Activity

“…DA-depleting neurotoxins have also been shown to reduce morphine-and amphetamine-induced analgesia in the Formalin rodent model. Increases in pain thresholds have also been described after DA D 2 receptor agonist administration, systemically or directly in the dorsal striatum (Altier and Stewart, 1999;Magnusson and Fisher, 2000). However, the opposite effects have also been shown in some animal models (e.g., visceral pain, deafferentization pain), in which the systemic and intracerebroventricular administration of DA D 2 antagonists was associated with antinociceptive effects (Lyerly et al, 1988;Frussa-Filho et al, 1996;Weizman et al, 2003).…”

“…Experiments in animal models have also suggested that DA activity in the nigrostriatal pathway is associated with pain suppression, an effect that appears mediated though DA D 2 receptors (Lin et al, 1981;Ben-Sreti et al, 1983;Morgan and Franklin, 1991;Altier and Stewart, 1999;Magnusson and Fisher, 2000). In this regard, the administration of levodopa, an indirect DA agonist, has been reported to reduce pain ratings in painful diabetic neuropathy in humans (Ertas et al, 1998).…”

Two Types of Epilepsy Models and Processes of Cognition: Pentylenetetrazole Kindling and Absence Epilepsy of WAG/Rij Rats Strain

“…We explain this reaction by the low efficiency of opioid system in WAG/Rij strain (Lason et al, 1990;1994a;1994b;Przewlocka et al, 1995) and as a consequence a low pain threshold and a high level of escape and avoidance motivation. It is shown (Altier & Stewart, 1998;Calabrese 2001) that activation of the DA-ergic system evokes analgesic reaction including activation of the opioid system (Suaudeau & Costentin, 1995;Cook et al, 2000;Magnusson & Fisher, 2000;Gao et al, 2001;Trekova et al, 2001). It was suggested that a deficit of dopaminergic system in WAG/Rij rats is the biological correlate of these behavioural deficits and that an enhanced sensitivity to DA-ergic agents is the consequence of this deficit.…”