The involvement of selenium in peroxisome proliferation caused by dietary administration of clofibrate to rats

Olsson, Ulf; Garberg, Per; Lundgren, Bo; Andersson, Karin; Hultenby, Kjell; Bergstrand, Anders; Eriksson, Anna Messing; Högberg, Johan; DePierre, Joseph W.

doi:10.1016/0009-2797(92)90052-m

Cited by 7 publications

(3 citation statements)

References 31 publications

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“…In Se-deficient animals, except for a slight decrease in glycogen granules, decreased number of peroxisomes and a decline in CAT immunohistochemistry and activity, we did not observe any significant changes in the morphology and International Journal of Experimental Pathology, 2014, 95, 64-77 structure of hepatocytes. Consistent with these observations, Olsson et al (1992) reported much less pronounced PP in Se-deficient rat livers. Moreover, we observed statistically significant increase in the number of apoptotic cells in SeD group vs. control group.…”

Section: Discussionsupporting

confidence: 79%

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The effects of di(2‐ethylhexyl)phthalate on rat liver in relation to selenium status

Erkekoğlu

Zeybek

Giray

et al. 2013

Int J Experimental Path

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This study was performed to determine the hepatotoxicity of di(2-ethylhexyl)phthalate (DEHP) in relation to selenium status. In 3-week-old Sprague-Dawley rats, selenium deficiency was induced by a ≤0.05 selenium mg/kg. A selenium supplementation group was given 1 mg selenium/kg diet for 5 weeks. Di(2-ethylhexyl)phthalate-treated groups received 1000 mg/kg dose by gavage during the last 10 days of the experiment. Histopathology, peroxisome proliferation, catalase (CAT) immunoreactivity and activity and apoptosis were assessed. Activities of antioxidant selenoenzymes [glutathione peroxidase 1 (GPx1), glutathione peroxidase 4 (GPx4), thioredoxin reductase (TrxR1)], superoxide dismutase (SOD), and glutathione S-transferase (GST); aminotransferase, total glutathione (tGSH), and lipid peroxidation (LP) levels were measured. Di(2-ethylhexyl)phthalate caused cellular disorganization while necrosis and inflammatory cell infiltration were observed in Se-deficient DEHP group (DEHP/SeD). Catalase activity and immunoreactivity were increased in all DEHP-treated groups. Glutathione peroxidase 1 and GPx4 activities decreased significantly in DEHP and DEHP/SeD groups, while GST activities decreased in all DEHP-exposed groups. Thioredoxin reductase activity increased in DEHP and DEHP/SeS, while total SOD activities increased in all DEHP-treated groups. Lipid peroxidation levels increased significantly in SeD (26%), DEHP (38%) and DEHP/SeD (71%) groups. Selenium supplementation partially ameliorated DEHP-induced hepatotoxicity; while in DEHP/SeD group, drastic changes in hepatic histopathology and oxidative stress parameters were observed.

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Section: Discussionsupporting

confidence: 79%

“…Consistent with these observations, Olsson et al . () reported much less pronounced PP in Se‐deficient rat livers. Moreover, we observed statistically significant increase in the number of apoptotic cells in SeD group vs .…”

Section: Discussionmentioning

confidence: 93%

The effects of di(2‐ethylhexyl)phthalate on rat liver in relation to selenium status

Erkekoğlu

Zeybek

Giray

et al. 2013

Int J Experimental Path

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“…Administration of clofibrate has been repeatedly shown to increase the number of peroxisomes in livers of rodents (e.g., [15,37,38]), the basis of their designation as peroxisome proliferators. Surprisingly, however, addition of clofibric acid to either the normal rodent chow or to the ketogenic diet failed to show a significant proliferation of peroxisomes within the hepatocytes (Rats #3 and #4).…”

Section: Discussionmentioning

confidence: 99%

A light- and electron-microscope study of hepatocytes of rats fed different diets

Eagles

Chapman

2006

Comptes Rendus. Biologies

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Ketogenic diets are used in the treatment of epilepsy in children refractory to drug therapy. This study identifies changes in liver morphology in rats fed four different diets: a normal rodent chow diet, a calorie-restricted high-fat (ketogenic) diet and each diet supplemented with clofibric acid. Hepatocytes of rats fed the ketogenic diet show many lipid droplets and these are reduced to control levels when clofibrate is present in the diet. Mitochondria are enlarged in the livers of rats fed the ketogenic diet and further enlarged if clofibrate is present.

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Effects of Peroxisome Proliferators on Glutathione and Glutathione-Related Enzymes in Rats and Hamsters

O’Brien

Cunningham

Spear

et al. 2001

Toxicology and Applied Pharmacology

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The involvement of selenium in peroxisome proliferation caused by dietary administration of clofibrate to rats

Cited by 7 publications

References 31 publications

The effects of di(2‐ethylhexyl)phthalate on rat liver in relation to selenium status

The effects of di(2‐ethylhexyl)phthalate on rat liver in relation to selenium status

A light- and electron-microscope study of hepatocytes of rats fed different diets

Effects of Peroxisome Proliferators on Glutathione and Glutathione-Related Enzymes in Rats and Hamsters

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