The iron deficiency anemia in association to Helicobacter pylori infection in Najran city, Saudi Arabia

Mubaraki, Murad A.; Alalhareth, Ahmed S.; Aldawood, Esraa; Albouloshi, Alaa; Aljarah, Mohammed S.; Hafiz, Taghreed A.; Alkhudhayri, Abdulsalam; Thagfan, Felwa A.; El‐Khadragy, Manal F.; Al-Megrin, Wafa Abdullah I.; Dkhil, Mohamed A.

doi:10.1016/j.jksus.2022.102353

Cited by 7 publications

(4 citation statements)

References 21 publications

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“…Anemia is an important public health concern and affects a sizeable portion of the global population, as per WHO report [19]. The high worldwide prevalence of anemia (>30%) has impacted all age categories in both developed and developing countries [20].…”

Section: Introductionmentioning

confidence: 99%

“…The economic burden of anemia on the healthcare sector varies based on severity, type, and comorbidities [21]. Iron deficiency anemia (IDA) has been reported by Mubaraki et al to be highly prevalent, especially in people of developing countries [19]. IDA has been recognized as the most frequent nutritional deficiency by the WHO, which affects a huge section (30%) of the global population [22].…”

Section: Introductionmentioning

confidence: 99%

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Helicobacter pylori (H. pylori) Infection-Associated Anemia in the Asir Region, Saudi Arabia

Al Mutawa,

Izhari,

Alharbi

et al. 2023

Diagnostics

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H. pylori (ubiquitous) and anemia together represent one of the growing health concerns globally. Gastroduodenal sequelae of H. pylori infection are distinguished; however, for the H. pylori infection and its implication in the development of anemia, iron has a significant health impact. We aimed to evaluate H. pylori infection-associated anemia by employing a logistic regression analysis model. A retrospective (case–control) study design-based assessment of the H. pylori associated-anemia. The study area was geo-referenced by QGIS/QuickMapServies. Descriptive and inferential statistical analyses were accomplished using the R-base–R-studio (v-4.0.2)-tidyverse. A p-value < 0.05 was the statistical significance cut-off value. A ggplot2 package was used for data representation and visualization. Mean ± SD age, Hb, MCV, ferritin, and RBC for overall study participants were measured to be 44.0 ± 13.58, 13.84 ± 2.49, 83.02 ± 8.31, 59.42 ± 68.37, and 5.14 ± 0.75, respectively. Decreased levels of Hb (infected vs. uninfected: 13.26 ± 2.92 vs. 14.42 ± 1.75, p < 0.001) ferritin (infected vs. uninfected: 48.11 ± 63.75 vs. 71.17 ± 71.14, p < 0.001), and MCV (infected vs. uninfected: 81.29 ± 9.13 vs. and 84.82 ± 6.93, p < 0.05) were measured to be associated with H. pylori infection when compared with H. pylori uninfected control group. Moreover, the magnitude (prevalence) of anemia (infected vs. uninfected: 78% vs. 21%, p < 0.001), iron deficiency anemia (IDA) (infected vs. uninfected: 63.3% vs. 36.6%, p < 0.001), and microcytic anemia (infected vs. uninfected: 71.6% vs. 46.1%, p < 0.001) were significantly different among the H. pylori-infected participants. The higher likelihood of developing anemia (AOR; 4.98, 95% CI; 3.089–8.308, p < 0.001), IDA (AOR; 3.061, 95% CI; 2.135–4.416, p < 0.001), and microcytic anemia (AOR; 3.289, 95% CI; 2.213–4.949, p < 0.001) by 398%, 206.1%, and 229%, respectively, was associated with H. pylori-infected. We recommend the regular monitoring of hematological parameters and eradication of H. pylori infection to minimize the extra-gastric health consequences of H. pylori infection.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Helicobacter pylori (H. pylori) Infection-Associated Anemia in the Asir Region, Saudi Arabia

Al Mutawa,

Izhari,

Alharbi

et al. 2023

Diagnostics

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“…Persistent infection with H. pylori increases the risk of developing gastric cancer and gastric mucosa-associated lymphoid tissue lymphoma in adults [ 2 ]. H. pylori may also have a role in uninvestigated and functional dyspepsia, unexplained iron deficiency anemia [ 3 ], and idiopathic thrombocytopenic purpura [ 4 ]. Many gastrointestinal diseases infected with H. pylori will develop clinically significant sequelae, such as peptic ulcer disease and gastric cancer [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Artesunate Dry Emulsion Formulation Combined with Antibiotics for Treatment of Helicobacter pylori Infections: In Vitro/In Vivo Evaluation

Le-Tien,

Blemur,

Baltzis

2023

IJMS

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Helicobacter pylori is the primary pathogen responsible for causing gastroduodenal ulcers and stomach cancer. The standard treatment for H. pylori typically involves a combination of antibiotics and acid-reducing medications. However, the recurrence of ulcers is closely linked to the emergence of antibiotic resistance in H. pylori, necessitating the development of alternative drugs. This report focuses on the investigation of artesunate as a potential alternative to reduce antibiotic use and enhance effectiveness against H. pylori. Unfortunately, commercial artesunate is available in an acid form, which has poor solubility, especially in gastric acid fluid. The aim of this study is to utilize a water-soluble formulation of artesunate called dry emulsion formulation (ADEF) and combine it with amoxicillin to eradicate H. pylori. In vitro studies were conducted to evaluate the activity of ADEF against H. pylori and determine its inhibitory concentrations. In addition, pharmacokinetic parameters of orally administered ADEF and native artesunate were investigated in rats for in vivo studies. The results showed that when combined with amoxicillin and pantoprazole, ADEF exhibited effectiveness against H. pylori. It is worth noting that the solubility of ADEF in gastric acid appears to be a critical factor for achieving successful treatment. Consequently, ADEF could be considered a promising candidate for H. pylori therapy.

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“…Various Factors including age, gender, education, lifestyle, health condition, number of family members and financial status as well as area of residence could affect the prevalence of H. pylori in the population. However, the correlation between these factors and H. pylori infection is inconclusive [8,11]. Also, the other potential risk factors, including occupational risk factors, water supply, and food were analyzed, as well as gastroesophageal reflux and sexual partners have been associated with a higher risk for H. pylori acquisition.…”

Section: Introdcutionmentioning

confidence: 99%

Prevalence and Associated Risk Factors of Helicobacter Pylori Infection among Patients Complaint Upper Gastrointestinal Tract Symptoms

Rahatullah¹

2023

JHMCS

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Aim: This study sought to investigate the prevalence of H. pylori infection and its associated factors among patients’ complaints upper gastrointestinal tract symptoms who attended Spinghar Momand Curative and Teaching Hospital, Jalalabad city, Afghanistan. Methods: Analytical cross-sectional study was performed among patients’ complaint upper gastrointestinal tract symptoms between September 2022 and January 2023. The diagnosis of H. pylori infection was done using antigen rapid stool test and data was analyzed through SPSS version 20. The study included 122 patients. Results: The study found that the overall prevalence of H. pylori infection was 71.3 %. The prevalence for females was 47 (54 %), males 40 (46 %), 18-25 years old was 32 (26.2 %), 25-50 years old 69 (56.6 %), above 50 years old 21 (17.2 %), urban residence 24 (28 %), rural residence 63 (72.4 %), married (77 %), unmarried 20 (23 %). Moreover, for good, medium, poor income were 11 (12.6 %), 48 (55.2 %) and 28 (32.2 %) respectively. In addition, the prevalence for 2-5, 5-10 and above 10 members of family were 6 (6.9 %), 26 (29.9 %) and 55 (63.2 %) respectively. Additionally, the association of H. pylori infection with hygienic and unhygienic condition was (31 %) and (69 %). Furthermore, the specific prevalence for pipe was 6 (6.9 %), well 63 (42.4 %), Tank 12 (13.8 %), stream 4 (4.6 %) and River water 2 (2.3 %). Remarkably, most of the patients have epigastric pain as well as diabetes and blood group have positive relationship with H. pylori infection, but there was no association with BMI categories. Conclusion: Prevalence of H. pylori infection was associated with age, marital status, hand washing, family income, living place, family members, drinking water, diabetes and blood group, but no association was found between infection and BMI categories. Recommendation: The study recommend that at the health sector level, strategies must be developed to ensure health status. Medical professionals must pay attention to epigastric pain and diabetes among the clinical features of the disease. People in the community should pay attention to the use of drinking water and hygiene.

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The iron deficiency anemia in association to Helicobacter pylori infection in Najran city, Saudi Arabia

Cited by 7 publications

References 21 publications

Helicobacter pylori (H. pylori) Infection-Associated Anemia in the Asir Region, Saudi Arabia

Helicobacter pylori (H. pylori) Infection-Associated Anemia in the Asir Region, Saudi Arabia

Artesunate Dry Emulsion Formulation Combined with Antibiotics for Treatment of Helicobacter pylori Infections: In Vitro/In Vivo Evaluation

Prevalence and Associated Risk Factors of Helicobacter Pylori Infection among Patients Complaint Upper Gastrointestinal Tract Symptoms

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