The ketogenic diet is not effective in preclinical models of IDH1 wild-type and IDH1 mutant glioma

Abstract

12 2 13 ABSTRACT 14 Infiltrative gliomas are the most common neoplasms arising in the brain, and remain largely 15 incurable despite decades of research. A subset of these gliomas contains mutations in isocitrate 16 dehydrogenase 1 (IDH1 mut ). This mutation disrupts cellular biochemistry, and IDH1 mut gliomas are