The kinetic study of the thermally induced degradation and an evaluation of the drug–excipient interactions performed for a new-generation bisphosphonate—risedronate

Drug excipient compatibility studies are considered important in successful formulation of drug products. Suggested methods for this purpose are thermal techniques under isothermal or nonisothermal conditions. In this study, modafinil, a wakefulness-promoting drug, was investigated under nonisothermal conditions using differential scanning calorimetry. Four different heating rates, 5, 10, 15, and 20°C/min, were performed for modafinil pure material and its physical mixtures with magnesium stearate (MgSt) or Gelucire 48/16. Activation energy (Ea) was calculated from the straight line of plotting a function of heating rate versus temperature and found that modafinil-Gelucire physical mixture increased Ea. This indicates drug-excipient interaction, supported by evidence from Fourier transform infrared spectroscopy and nuclear magnetic resonance spectroscopy. No significant interaction was detected with MgSt.

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“…This ratio (1:1 w/w) is usually selected in compatibility studies to increase interaction possibilities. [ 29 ]…”

Section: Methodsmentioning

confidence: 99%

Modafinil-excipient compatibility study using differential scanning calorimetry

Omari

Sallam²,

Al-Hmoud³

et al. 2023

Journal of Advanced Pharmaceutical Technology &Amp; Research

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“…Since the middle of the 20th century, the equipment used in the measurement of thermal analysis (TA) and related data processing methods have developed rapidly to study reaction kinetics, , making thermal analysis one of the most common and widely used laboratory technologies. − Thermal analysis measurements include differential thermal analysis (DTA), differential scanning calorimetry (DSC), and thermogravimetry (TG). − Activation energy is the main potential factor for ignition and combustion of pyrotechnic materials. , …”

Section: Introductionmentioning

confidence: 99%

“… 22 − 25 Thermal analysis measurements include differential thermal analysis (DTA), differential scanning calorimetry (DSC), and thermogravimetry (TG). 26 − 30 Activation energy is the main potential factor for ignition and combustion of pyrotechnic materials. 31 , 32 …”

Section: Introductionmentioning

confidence: 99%

Kinetics and Combustion Behavior of Atomized Zn–Mg Alloy Powder

Zhang

Zhu

Xie³

et al. 2023

ACS Omega

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Using pyrolants instead of warhead charges can release red light and thick smoke for target practice to highlight the safety of the impact point and dud disposal. In order to find the ideal material, the combustion and kinetic properties of two Zn–Mg alloys at critical proportions were investigated. Thermogravimetry/differential scanning calorimetry (TG/DSC) experiments in pure oxygen were conducted with atomized Zn–Mg alloy powder in the ratio of 7:3 and the ratio of 8:2 with three particle diameters under different heating rates. The kinetic parameters of the six materials were obtained by ASTM E698 and Ozawa–Flynn–Wall (OFW) methods, indicating that the activation energy (E α) of the 7:3 Zn–Mg alloy powder was lower than that of the 8:2 Zn–Mg alloy powder when the particle size distributions are similar. By the method of nonlinear multivariate regression, the oxidation reaction of Zn–Mg alloy powder was divided into two steps. The proportion of mass gain of the first-step reaction of 7:3 Zn–Mg alloy powder was 0.462–0.518, and the proportion of mass gain of the first-step reaction of 8:2 Zn–Mg alloy powder was 0.138–0.228. Reaction mechanism functions of the two-step reaction of Zn–Mg alloy oxidation were derived as f(α) = (1 – α) n (1 + k cat·α). The results of combustion experiments showed that the pyrolants composed of 7:3 alloy can burn stably to produce satisfactory smoke and light signals, while the pyrolants composed of 8:2 alloy cannot achieve this. The 7:3 Zn–Mg alloy powder is an ideal ingredient for pyrotechnic compositions.

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“…Thermal analysis techniques such as differential scanning calorimetry (DSC), differential thermal analysis (DTA), and Thermogravimetry (TG) are widely used in studies of pre-formulation, drugs, and substance development of pharmaceutical interest [ 26 , 27 ]. Thermal analysis techniques are used in many studies to study incompatibilities between active substances: excipients [ 28 , 29 , 30 , 31 ] and also Pharmacopeias described the thermal analysis methods as general techniques. However, at the same time, the description of their uses is relatively limited on Pharmacopeias because only a few studies on purity determination, loss on drying of reference substances, polymorphic studies, solvates and hydrates, determination of melting point, and quantification of volatile components in drugs are highlighted in Pharmacopeias.…”

Section: Introductionmentioning

confidence: 99%

Preliminary Study for the Preparation of Transmucosal or Transdermal Patches with Acyclovir and Lidocaine

et al. 2021

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The present study aimed to prepare and evaluate patches for the controlled release of lidocaine/acyclovir and the binary mixture between lidocaine: acyclovir in the oral cavity. Mucoside adhesive patches containing 12.5 mg/cm2 lidocaine/acyclovir or binary mixture base were developed by a solvent casting method using sodium alginate, polyvinylpyrrolidone (PVP), glycerol (Gly), polyvinyl alcohol (PVA), and Span 80 (S). Binary mixtures between all components were prepared before the patches’ formulation in order to be able to check the substance compatibility. All formulated patches were analyzed by FT-IR spectroscopy, UV-Vis analysis, thermogravimetry (TGA), and scanning electron microscopy (SEM). FT-IR and TGA analyses were also used to check compatibility between binary mixtures. The study establishes which membranes are indicated in the controlled release of lidocaine/acyclovir and those membranes that contain both active principles. Membranes based on alginate, PVP, and PVA can be used to release the active substance. Simultaneously, membranes with SPAN used as a gelling agent were excluded due to the interaction with the active substance. The following membranes composition have been chosen for lidocaine release: Alginate:Gly and Alginate:Gly:PVP. At the same time, the following membrane compositions were chosen for acyclovir membranes: Alginate:Gly:PVP and Alginate:PVA:Gly. Both active substances could be included to obtain a homogeneous distribution only in the membrane based on alginate, PVA, and Gly.

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The kinetic study of the thermally induced degradation and an evaluation of the drug–excipient interactions performed for a new-generation bisphosphonate—risedronate

Cited by 7 publications

References 32 publications

Modafinil-excipient compatibility study using differential scanning calorimetry

Modafinil-excipient compatibility study using differential scanning calorimetry

Kinetics and Combustion Behavior of Atomized Zn–Mg Alloy Powder

Preliminary Study for the Preparation of Transmucosal or Transdermal Patches with Acyclovir and Lidocaine

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