2010
DOI: 10.1016/j.biomaterials.2010.07.045
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The kinetics of the tissue distribution of silver nanoparticles of different sizes

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Cited by 458 publications
(402 citation statements)
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“…The CT image of Figure 4A shows that AgNPs mainly accumulated in the spleen with deep red region (≈186 HU), which is consistent with the report of Lankveld et al [43] After exposure to GO/AgNPs (Figure 4A), the lung in the images of CT shows a glassy yellow region(approximately −125 HU), but one of the control groups shows a shiny red region(approximately −400 HU), suggesting that the accumulation of GO/AgNPs in the lung increases significantly. Therefore, through the color comparison, it is found that the biodistribution pattern of AgNPs is different from GO/AgNPs.…”
Section: Ct Imaging Of Go/agnps In Vivosupporting
confidence: 90%
“…The CT image of Figure 4A shows that AgNPs mainly accumulated in the spleen with deep red region (≈186 HU), which is consistent with the report of Lankveld et al [43] After exposure to GO/AgNPs (Figure 4A), the lung in the images of CT shows a glassy yellow region(approximately −125 HU), but one of the control groups shows a shiny red region(approximately −400 HU), suggesting that the accumulation of GO/AgNPs in the lung increases significantly. Therefore, through the color comparison, it is found that the biodistribution pattern of AgNPs is different from GO/AgNPs.…”
Section: Ct Imaging Of Go/agnps In Vivosupporting
confidence: 90%
“…Computational physiologically-based pharmacokinetic (PBPK) models can incorporate toxicokinetic data along with species-specific physiological properties to study the post-exposure absorption, distribution, metabolism and excretion (ADME) of MNs (Lee et al, 2009, Riviere, 2009, Lankveld et al, 2010, Van Kesteren et al, 2014. Specific PBPK tools were proposed by Lee et al (2009) for quantum dots, by Lankveld et al (2010) for nano Ag, and by Van Kesteren et al (2014) for nano SiO 2 . A generic PBPK model for MNs was developed by IOM in collaboration with the U.S. NIOSH agency in the context of the EU FP7 ENPRA and MARINA projects (Riviere, 2014).…”
Section: Behaviour and Fate Experimentsmentioning
confidence: 99%
“…The same group has demonstrated that repeated doses of 42 nm uncoated Ag NPs were able to induce significant inflammation, involving increase of the cytokines produced, B cells distribution and tissue infiltration of inflammatory cells [16]. Distribution and accumulation of three different Ag NPs sizes (20,80 and 110 nm), administered by intravenous injection in rats once daily for 5 days, were found for the smallest Ag NPs (20 nm) in liver, kidneys and spleen, and for the larger Ag NPs (80 and 110 nm) in spleen, liver and lung [17]. The size-dependent distribution suggests those organ can be potential targets for Ag NPs in a size-dependent way.…”
Section: Introductionmentioning
confidence: 99%