The Kleine-Levin Syndrome

Huang, Yu‐Shu; Arnulf, Isabelle

doi:10.1016/j.jsmc.2005.11.011

Cited by 13 publications

(4 citation statements)

References 78 publications

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“…The gradual or rapid return to normality at the end of episode is characteristic of the Kleine-Levin syndrome. Our patients effectively recovered a clinical normal state between episodes, as reported in the literature by several authors [ 1 , 2 , 4 – 6 ]. As described in literature [ 2 ], the second patient sometimes presented insomnia out of the hypersomenia episode.…”

Section: Discussionsupporting

confidence: 83%

“…This is the case in our study. A functional imaging study of brain scan during the symptomatic period objectified frequent transient hypoactivity in the thalamic region and to a lesser degree of the hypothalamus and the frontal and temporal regions [ 6 ]. These cerebral hypoperfusion areas support the hypothesis of diencephalic and clinical symptoms of the Kleine-Levin syndrome.…”

Section: Discussionmentioning

confidence: 99%

“…The limited nature in time of effect limits the practical usefulness of this drug even though it involves the part of the GABA-A receptor in the pathophysiology of Kleine-Levin syndrome. In all cases it is necessary, according to Oliveira et al, as well as other authors, to perform double-blind clinical trials and pharmacological treatment for Kleine-Levin syndrome [ 6 , 10 – 12 ].…”

Section: Discussionmentioning

confidence: 99%

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The Kleine-Levin Syndrome: A Rare Disease with Often Delayed Diagnosis—A Report of Two Cases in the Department of Neurology of the University Hospital of Cocody (Côte d’Ivoire)

Berthé

Yapo-Ehounoud

Baby

et al. 2016

Case Reports in Neurological Medicine

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The Kleine-Levin syndrome is a rare pathology characterized by recurrent episodes of hypersomnia associated with behavioral and cognitive disorders with, among others, hyperphagia and hypersexuality. The disease mainly affects young males. A few studies mention cases that occurred in Africa, especially in Côte d'Ivoire. In this paper, we report the very first two cases observed in the Neurology Department of the University Hospital of Cocody. The diagnosis was clinical, based on the recurrence of hypersomnia, cognitive and behavioral disorders during the periods of hypersomnia, and the return of patients to normal state between episodes. This diagnosis was delayed due to failure to understand the pathology, thereby leading patients to wandering. In fact, the two patients were consulted, respectively, 3 years and 6 years after the hypersomnia began. The objective was to report the very first cases observed in the Neurology Department of the University Hospital of Cocody, Côte d'Ivoire.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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The Kleine-Levin Syndrome: A Rare Disease with Often Delayed Diagnosis—A Report of Two Cases in the Department of Neurology of the University Hospital of Cocody (Côte d’Ivoire)

Berthé

Yapo-Ehounoud

Baby

et al. 2016

Case Reports in Neurological Medicine

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“…In one meta-analysis, the median age at disease onset was 15 years (range, 4–80 years), with 81% of the cases beginning during the second decade. [ 9 ] Cases starting before puberty were rare. Most cases are sporadic, but in few multiplex KLS families have been reported.…”

Section: Epidemiologymentioning

confidence: 99%

Kleine-Levin syndrome: Etiology, diagnosis, and treatment

Ramdurg

2010

Ann Indian Acad Neurol

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Kleine–Levin syndrome (KLS) is a rare sleep disorder mainly affecting teenage boys in which the main features are intermittent hypersomnolence, behavioral and cognitive disturbances, hyperphagia, and in some cases hypersexuality. Each episode is of brief duration varying from a week to 1–2 months and affected people are entirely asymptomatic between episodes. No definite cause has been identified, and no effective treatments are available even though illness is having well-defined clinical features. Multiple relapses occur every few weeks or months, and the condition may last for a decade or more before spontaneous resolution. In this study, PubMed was searched and appropriate articles were reviewed to highlight etiology, clinical features, and management of KLS. On the basis of this knowledge, practical information is offered to help clinicians about how to investigate a case of KLS, and what are the possible treatment modalities available currently for the treatment during an episode and interepisodic period for prophylaxis. Comprehensive research into the etiology, pathophysiology, investigation, and treatments are required to aid the development of disease-specific targeted therapies.

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Sleep and Its Disorders

Chokroverty¹,

Avidan²

2008

Neurology in Clinical Practice

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The Kleine-Levin Syndrome

Cited by 13 publications

References 78 publications

The Kleine-Levin Syndrome: A Rare Disease with Often Delayed Diagnosis—A Report of Two Cases in the Department of Neurology of the University Hospital of Cocody (Côte d’Ivoire)

The Kleine-Levin Syndrome: A Rare Disease with Often Delayed Diagnosis—A Report of Two Cases in the Department of Neurology of the University Hospital of Cocody (Côte d’Ivoire)

Kleine-Levin syndrome: Etiology, diagnosis, and treatment

Sleep and Its Disorders

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