The Korean traditional medicine Gyeongshingangjeehwan inhibits obesity through the regulation of leptin and PPARα action in OLETF rats

Jeong, Su-Ji; Chae, Kyungsil; Jung, Yang Sam; Rho, Young Ho; Lee, Jinmi; Ha, Juran; Yoon, Ki Hyeon; Kim, Gyeong Cheol; Oh, Ki Sook; Shin, Soon Shik; Yoon, Michung

doi:10.1016/j.jep.2008.06.037

Cited by 44 publications

(45 citation statements)

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“…맥문동(Liriope platyphylla)은 고대부터 한국과 중국에서 기침, 가래 등의 질병 치료를 목적으로 한방에서 주로 사 용되어왔으며, 최근에는 산업사회에서 빈번히 발생하는 당뇨, 치매 등의 치료와 더불어 기억력 증진, 미생물 억 제, 염증억제 등의 기능이 알려지면서 많은 연구가 진행 되고 있다 (Hur et al, 2004;Jeong et al, 2008). 이러 한 효능 중에서 가장 오랫 동안 연구되어온 기능은 항미 생물제와 항염증제로서의 기능이다 (Lee et al, 2005).…”

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“…맥문동의 homoisoflavone-고함유 분 획(homoisoflavone-enriched fraction)은 3T3-L1 지방세포 (adipocytes)의 인슐린과 글루코스 흡취(glucose uptake)를 증가시켜 인슐린 sensitizer로서 기능을 나타내었다 (Choi et al, 2004). 또한, OLEFT 비만 랫드를 이용한 실험에서, 8 주 동안의 맥문동이 첨가된 경신강제환의 투여는 체중, leptin 농도, 먹이섭취량, PPARγ 발현 등의 감소를 유발 하였다 (Jeong et al, 2008). 이러한 결과는 맥문동이 체내 의 지방대사와 혈당조절 기전에 밀접한 관련이 있음을 보 여주고 있다.…”

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The Symptoms of Atopic Dermatitis in NC/Nga Mice Were Significantly Relieved by the Water Extract ofLiriope platyphylla

et al. 2010

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Atopic dermatitis is an well-known skin disease showing inflammatory, chronically relapsing, noncontagious and pruritic symptoms. The aims of this study were to investigate the effects of Liriope platyphylla (LP) on atopic dermatitis of NC/Nga mice. To achieve this, NC/Nga mice were treated with four different conditions including vehicle, phthalic anhydride (PA), PA+5% LP and PA+10% LP, and the changes of immune-related factors were detected after 2 weeks. The pathological phenotypes of atopic dermatitis such as erythema, ear thickness, edema, scab and discharge were significantly decreased in PA+10% LP cotreated groups compare to PA treated group. Also, the weight of lymph node and thymus in immune organs were gradually decreased in LP treated groups, while the weight of spleen was slightly increased in same group. Furthermore, toluidine blue staining analysis, a method used to specifically identify the mast cell, showed that the decrease of master cell infiltration into the dermis were statistically observed in PA+5% LP and PA+10% LP5% cotreated groups. Especially, the decrease of IgE concentration was detected only PA+10% LP cotreated group, although this level was maintained in PA+5% LP cotreated group. Therefore, these results suggested that the water extracts of LP may contribute the relieve of atopic dermatitis symptoms and be considered as an excellent candidate for a atopic dermatitis-therapeutic drug.

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The Symptoms of Atopic Dermatitis in NC/Nga Mice Were Significantly Relieved by the Water Extract ofLiriope platyphylla

et al. 2010

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“…Recent studies show that medicinal plants inhibit obesity and improve metabolic disorders including hyperlipidemia, insulin resistance, and NAFLD (Jeong et al, 2008;Shin et al, 2010;Roh et al, 2015;Yoon et al, 2017). Gangjihwan for gene expression analysis are shown in Table 1.…”

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The Herbal Composition Gangjihwan fromEphedra intermedia, Lithospermum erythrorhizonandRheum palmatumAmeliorates Hepatic Inflammation and Fibrosis in Obese C57BL/6J Mice and HepG2 Cells

Yoon

2017

BSL

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It was demonstrated that Gangjihwan (DF), which is the herbal composition composed of Ephedra intermedia, Lithospermum erythrorhizon, and Rheum palmatum, inhibits obesity and hepatic steatosis in high fat diet (HFD)-fed obese mice. The aim of this study was to determine the effects of DF on visceral obesity, hepatic inflammation and fibrosis and the mechanism of actions involved in this process using in vivo and in vitro approaches. DF was extracted with water (DF-FW), 30% grain alcohol (DF-GA30), and 70% grain alcohol (DF-GA70). Administration of DF to HFD-fed control mice decreased visceral tissue mass and visceral adipocyte size without adverse effects. Visceral fat mass was decreased by DF-GA30 and DF-GA70, and visceral adipocyte size by all three DF extracts compared with obese control mice. Histological analysis revealed that three kinds of DF extracts reduced toluidine blue-stained mast cells and collagen accumulation in the liver, the extents of which were most eminent in DF-GA70-treated mice. DF-GA70 decreased the mRNA levels of the inflammation (TNFα and VCAM-1), fibrosis (α-SMA), and apoptosis (caspase 3) genes, but increasing the anti-apoptosis gene (Bcl-2) mRNA levels in the liver of obese control mice. Consistent with the in vivo data, GA-70 also altered the expression of inflammation genes (TNFα and MCP-1) in HepG2 cells. These results indicate that DF not only inhibits visceral obesity, but also ameliorates visceral obesity-induced hepatic inflammation and fibrosis and that this process may be mediated by regulating the hepatic expression of inflammatory and fibrogenic genes.

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“…The fi ndings suggest that AEtLP should be considered as a diabetes therapeutic candidate to induce insulin secretion from pancreatic β-cells and glucose uptake in liver cells. Department of Experimental Animal Research, Clinical Research Institute, Seoul National University Hospital, 6 College of Pharmacy, Chungbuk National University, Chungju 361-763, Republic of Korea Abstract 2004;Hur et al, 2004;Jeong et al, 2008;Hur et al, 2009). Anti-infl amation and anti-microbial effects have been studied for a very long time.…”

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confidence: 99%

“…The potential of L. platyphylla in the treatment of obesity and diabetes has been reported (Choi et al, 2004;Jeong et al, 2008). The effects of Gyeongshingangjeehwan (mainly containing L. platyphylla) in preventing obesity and hypertriglyceridemia through the inhibition of feeding and the activation of hepatic peroxisome proliferator-activated receptoralpha in OLETF male rats was reported (Jeong et al, 2008).…”

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Aqueous Extracts of Liriope platyphylla Are Tightly-Regulated by Insulin Secretion from Pancreatic Islets and by Increased Glucose Uptake through Glucose Transporters Expressed in Liver Hepatocytes

Kim¹,

Nam²,

Choi³

et al. 2011

Biomolecules and Therapeutics

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L. platyphylla is a perennial herb plant that is widely-distributed in temperate climate regions of the northern hemisphere. In Korea, these plants mainly grow mountainous regions at low altitude (i.e., <500 m sea level) and their leaves remain green year-round (Huh et al., 2007). L. platyphylla has been the basis of a traditional oriental herbal medicine that has been long-used for the treatment of asthma and bronchial and lung infl ammation (Lee et al., 2005). Data from several sciencebased studies has demonstrated the therapeutic effectiveness of the extract of the roots of L. platyphylla in the treatment of obesity, diabetes and neurodegenerative disease (Choi et al., Liriope platyphylla is a medical herb that has long been used in Korea and China to treat cough, sputum, neurodigenerative disorders, obesity and diabetes. The aims of this study were to study the antidiabetic effects of the aqueous extract of L. platyphylla (AEtLP) through pancreatic and extrapancreatic actions. AEtLP were orally administrated to ICR mice once a day for 7 days. Of three different concentrations of AEtLP, only 10% AEtLP were low toxic to liver, based on body weight and serum biochemical analyses. However, 10% AEtLP-treated mice displayed signifi cant reduction of the glucose concentration and increased insulin concentration; no changes were noted using 5% and 15% AEtLP. Also, the increase of glucose transporter (Glut)-1 expression in liver was dependent on the concentration of AEtLP, and was regulated by the phosphorylation of Akt. The lowest expression of Glut-3 was observed in 15% AEtLP treated mice, followed by 10% AEtLP-and 5% AEtLP-treated mice. This pattern of Glut-3 expression was roughly in accord with the phosphorylation of c-Jun N-teminal kinase (JNK) in the mitogen-activated protein kinase (MAPK) pathway. Furthermore, a signifi cant rise of the superoxide dismutase activity (SOD) was detected in AEtLP-treated mice. The fi ndings suggest that AEtLP should be considered as a diabetes therapeutic candidate to induce insulin secretion from pancreatic β-cells and glucose uptake in liver cells. Department of Experimental Animal Research, Clinical Research Institute, Seoul National University Hospital, 6 College of Pharmacy, Chungbuk National University, Chungju 361-763, Republic of Korea Abstract 2004;Hur et al., 2004;Jeong et al., 2008;Hur et al., 2009). Anti-infl amation and anti-microbial effects have been studied for a very long time. Kim et al. (2002) screened the extracts of many plants for anti-bacterial effects drugs via the detection of the inhibition of sortase (an enzyme found in most Gram-positive bacteria that is important in bacterial adhesion). Among 80 medical plants tested, L. platyphylla, Cocculus trilobus, Fritillaria verticillata, and Rhus vernicifl ua had strong anti-bacterial activity. Also, L. platyphylla potently inhibits airway infl ammation and hyperresponsiveness in a murine model of asthma by modulating the relationship between Th1/Th2 cytokine imbalance (Lee et al., 2005) as well as a...

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The Korean traditional medicine Gyeongshingangjeehwan inhibits obesity through the regulation of leptin and PPARα action in OLETF rats

Cited by 44 publications

References 35 publications

The Symptoms of Atopic Dermatitis in NC/Nga Mice Were Significantly Relieved by the Water Extract ofLiriope platyphylla

The Symptoms of Atopic Dermatitis in NC/Nga Mice Were Significantly Relieved by the Water Extract ofLiriope platyphylla

The Herbal Composition Gangjihwan fromEphedra intermedia, Lithospermum erythrorhizonandRheum palmatumAmeliorates Hepatic Inflammation and Fibrosis in Obese C57BL/6J Mice and HepG2 Cells

Aqueous Extracts of Liriope platyphylla Are Tightly-Regulated by Insulin Secretion from Pancreatic Islets and by Increased Glucose Uptake through Glucose Transporters Expressed in Liver Hepatocytes

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