The Laboratory Diagnosis of Herpes Simplex Virus Infections

Singh, Ameeta E.; Preiksaitis, Jutta; Romanowski, Barbara

doi:10.1155/2005/318294

Cited by 104 publications

(58 citation statements)

References 43 publications

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“…Existen otros métodos diagnósticos directos, entre los que se encuentran el aislamiento viral mediante cultivo (método de elección para distinguir entre herpes virus tipo 1 o 2), la detección del antígeno viral mediante inmunofluorescencia directa, la microscopía electrónica (no distingue el tipo de herpes) y la detección del ADN viral mediante técnicas de hibridación [5,9].…”

Section: Discussionunclassified

Perianal herpetic ulcers in immunosuppressed patients. Report of two cases

Domínguez¹,

Jara²,

Barboza³

et al. 2017

Our Dermatol Online

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Genital herpes is the most common cause of ulcers in sexually transmitted diseases (STDs). It is presented as a single or multiple, painful injury, accompanied by bilateral, also painful, lymphadenopathy. In immunocompromised patients, such as those affected by HIV, Herpes Simplex Virus (HSV) infections have a variety of clinical manifestations; they may be located, scattered or atypical. In addition, lesions may be more extensive and persistent than HIV-negative patients. We present two cases of immunocompromised patients with perianal herpetic ulcers, one HIV carrier, and the other with leukopenia caused by visceral Leishmaniasis.

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Section: Discussionunclassified

Perianal herpetic ulcers in immunosuppressed patients. Report of two cases

Domínguez¹,

Jara²,

Barboza³

et al. 2017

Our Dermatol Online

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“…Clear differences were noted in hepatitis C risk behaviors. Men had higher rates of lifetime drug-related risk behaviors: due to needle use needle sharing and crack cocaine use [20]. Recently, HCV prevalence studies have been reported from Pakistan and Middle East.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and epidemiology of hepatitis C virus (HCV) infection in Rafsanjan

Fatemipour¹,

Fatemipour

Vahedi

et al. 2016

Iran J Virol

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Background and Aims: Many individuals with chronic hepatitis C virus (HCV) infection are asymptomatic, population-based serologic studies are needed to estimate the prevalence of infection which will help to take necessary procedures for prevention and control the disease. This study was conducted to find out the prevalence, of HCV infection among patients referring to the hospital care in Rafsanjan, Iran. Materials and Methods: A total of 940 blood samples (430 males and 510 females) were received and screened for hepatitis C infection during December 2015 to December 2016. After separation of serum from blood samples in local laboratory, all samples were tested for HCV Ag by ELISA tests. Liver enzymes [Alkalin Phosphatase (ALP), Alanine aminotrans¬ferase (ALT) and Aspartate aminotransferase (AST)] were determined using biochemical procedures. Results: Amongst 940 collected samples, 18 (1.91%) were positive for HCV Antibody. Among the positive ones, HCV hepatitis was more prevalent in male patients than the females. The prevalence rate of HCV in male was 3.72% and 0.39% for female. Results related to age showed that higher rate of infection in 20-29 years old (%26.59), and the lowest was found in above 80 years old group (0.31%). Of the three enzymes, only ALP was significantly higher than the control group (P=0.003). Conclusions:The prevalence of HCV in Rafsanjan was at an increasing rate. Findings from the current study will be helpful for better management and control of viral hepatitis C infection.

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“…Therefore, laboratory testing methods are routinely used to support the diagnosis. Viral culture was once the gold standard for HSV diagnosis, but as a result of the long turnaround time and reduced sensitivity of the method compared with molecular testing, viral culture for HSV has largely fallen out of favor (39 ). Nucleic acid testing by PCR assay of a swab of a lesion is highly sensitive in an individual presenting with active lesions (40,41 ).…”

Section: Herpes Simplex Virusmentioning

confidence: 99%

“…Of those subtypes, Ͼ40 can infect the genital tract. Subtypes 6 and 11 are most often associated with genital warts, whereas infection with high-risk subtypes including 16,18,31,33,35,39,45,51,52,56,58,59,66, and 68 are linked to cervical and rectal neoplasia (81 ).…”

Section: Human Papilloma Virusmentioning

confidence: 99%

The ABCs of STIs: An Update on Sexually Transmitted Infections

Yarbrough

Burnham

2016

Clinical Chemistry

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BACKGROUND Sexually transmitted infections (STIs) are spread primarily through sexual contact and are a major cause of morbidity and mortality worldwide. Once identified, some STIs can be cured following appropriate therapy; for others, suppressive regimens and approaches to prevent ongoing transmission are important. The incidence of many common STIs is increasing in the US as well as worldwide, and hundreds of millions of people are currently infected. Laboratory testing plays a major role in the diagnosis and treatment of STIs, and clinical laboratorians should be familiar with the current guidelines and methods for testing. CONTENT Accurate and sensitive methods to diagnose STIs are essential to direct appropriate antimicrobial therapy and interrupt the cycle of disease transmission. This review summarizes laboratory testing for common bacterial, viral, and parasitic causes of STIs. Disease manifestations reviewed include cervicitis and urethritis, genital ulcerative disease, human immunodeficiency virus, viral hepatitis, human papilloma virus, and vaginitis. Recent advancements in the recognition and management of STIs, including updates to diagnostic algorithms, advances in testing methods, and emerging challenges with antimicrobial resistance, are summarized. SUMMARY Diagnostic methods and therapeutic guidelines for STIs are rapidly evolving. In combination with changing epidemiology, the development of novel therapeutics, and advancements in diagnostic methods, this has resulted in changing practices in laboratory testing and, subsequently, management of disease. Molecular methods have facilitated personalized therapy and follow-up regimens targeted for individual types or strains of some STIs.

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The Laboratory Diagnosis of Herpes Simplex Virus Infections

Cited by 104 publications

References 43 publications

Perianal herpetic ulcers in immunosuppressed patients. Report of two cases

Perianal herpetic ulcers in immunosuppressed patients. Report of two cases

Prevalence and epidemiology of hepatitis C virus (HCV) infection in Rafsanjan

The ABCs of STIs: An Update on Sexually Transmitted Infections

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