The Lack of Negative Affects as an Indicator for Identity Disturbance in Borderline Personality Disorder: A Preliminary Report

Walter, Marc; Berth, Hendrik; Selinger, Joseph; Gerhard, Urs; Küchenhoff, Joachim; Frommer, Jörg; Dammann, Gerhard

doi:10.1159/000241196

Cited by 19 publications

(12 citation statements)

References 66 publications

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“…Up to 10% of patients commit suicide, a rate almost 50 times higher than in the general population. Several measures (semi-structural interviews) are highly reliable in the care of these patients [8-10]. Causal factors for BPD are only partly known, but genetic factors [11-13] and adverse events during childhood, such as physical and sexual abuse [14], contribute to the development of the disorder.…”

Section: Introductionmentioning

confidence: 99%

Aberrant Methylation of Gene Associated CpG Sites Occurs in Borderline Personality Disorder

et al. 2013

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Borderline personality disorder (BPD) is a complex psychiatric disease with an increased impact in the last years. While the diagnosis and therapy are well established, little is known on the pathogenesis of borderline personality disorder. Previously, a significant increase in DNA methylation of relevant neuropsychiatric genes in BPD patients has been reported. In our study we performed genome wide methylation analysis and revealed specific CpG sites that exhibited increased methylation in 24 female BPD patients compared to 11 female healthy controls. Bead chip technology and quantitative bisulfite pyrosequencing showed a significantly increased methylation at CpG sites of APBA2 (1.1 fold) and APBA3 (1.1 fold), KCNQ1 (1.5 fold), MCF2 (1.1 fold) and NINJ2 (1.2 fold) in BPD patients. For the CpG sites of GATA4 and HLCS an increase in DNA methylation was observed, but was only significant in the bead chip assay. Moreover genome wide methylation levels of blood samples of BPD patients and control samples are similar. In summary, our results show a significant 1.26 fold average increase in methylation at the analyzed gene associated CpG sites in the blood of BPD patients compared to controls samples (p<0.001). This data may provide new insights into epigenetic mechanisms underlying the pathogenesis of BPD.

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Section: Introductionmentioning

confidence: 99%

Aberrant Methylation of Gene Associated CpG Sites Occurs in Borderline Personality Disorder

et al. 2013

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“…It has been argued that identity diffusion may be correlated with high levels of self-rated psychopathology and negative affectivity [39]. …”

Section: Introductionmentioning

confidence: 99%

Associations between Identity Diffusion, Axis II Disorder, and Psychopathology in Inpatients with Borderline Personality Disorder

et al. 2011

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Background: Patients with borderline personality disorder (BPD) suffer from instability in their relationships, their affectivity, and their identity. However, the associations between these dimensions are not clear. The purpose of the present study was to investigate the relation between identity diffusion and psychopathology in BPD. Methods: In the second week of inpatient treatment, 52 patients with BPD were assessed with the Inventory of Personality Organization (IPO) and questionnaires measuring general psychiatric symptoms, mood states, and negative affects (SCL-90-R, BDI, STAI, and STAXI). A median split was examined to differentiate BPD patients with high identity diffusion from those with low identity diffusion. Results: BPD patients with high identity diffusion did not differ in their social data from BPD patients with low identity diffusion. However, BPD patients with high identity diffusion showed significantly higher levels of psychiatric symptoms, as well as higher anxiety, anger, and depression scores (p < 0.01). Moreover, they suffered more frequently from concurrent personality disorders (p < 0.05). Conclusions: These findings indicate an association of identity diffusion with psychopathological symptoms and features of personality disorder and emphasize the clinical significance of identity diffusion for patients with BPD.

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“…Komorbide Suchterkrankungen wirken sich wiederum ungünstig auf den Verlauf der Persönlichkeitsstörung aus. [114]. Im Sinne einer Verhaltensenthemmung zeigt sich die Impulsivität entsprechend tendenziell stärker bei Patienten mit einer BPS und einer Substanzabhängigkeit als bei Patienten mit einer BPS ohne Substanzabhängigkeit [115].…”

Section: Klinischer Verlauf Bei Komorbiditätunclassified

Persönlichkeitsstörungen und Sucht: Systematische Literaturübersicht zu Epidemiologie, Verlauf und Behandlung

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Sollberger

Bader

et al. 2015

Fortschr Neurol Psychiatr

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The Lack of Negative Affects as an Indicator for Identity Disturbance in Borderline Personality Disorder: A Preliminary Report

Cited by 19 publications

References 66 publications

Aberrant Methylation of Gene Associated CpG Sites Occurs in Borderline Personality Disorder

Aberrant Methylation of Gene Associated CpG Sites Occurs in Borderline Personality Disorder

Associations between Identity Diffusion, Axis II Disorder, and Psychopathology in Inpatients with Borderline Personality Disorder

Persönlichkeitsstörungen und Sucht: Systematische Literaturübersicht zu Epidemiologie, Verlauf und Behandlung

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