The Late and Persistent Pathogenic Effects of Cadmium at Very Low Levels on the Kidney of Rats

Wang, Bo; Luo, Qi; Shao, Chen; Li, Xin; Li, Feng; Liu, Yanan; Sun, Liankun; Li, Yang; Cai, Lu

doi:10.2203/dose-response.11-046.wang

Cited by 21 publications

(17 citation statements)

References 47 publications

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“…Bar = 100 µm. The data was from the same models published recently with different images from published ones [52]. The time-dependence of Cd-induced change of DNMT activity was also supported by other studies.…”

Section: Effect Of CD On Dnmt Activitysupporting

confidence: 78%

“…We recently found the changes of miRNA expression in the liver of rats at 48 th week after chronic low-dose Cd (20 nmol/kg) every other day for 4 weeks, same as the animal model reported recently [52,54]. Altered CpG island methylation fragments associated with miRNAs and correspondence genes in the liver are listed in Table 2.…”

Section: Mirnasupporting

confidence: 72%

“…Recently we have investigated the methylation effect of Cd in an in vivo condition. In this study, male Wistar rats were given Cd at 20 nmol/kg every other day for 4 weeks, which caused a long-lasting renal and hepatic accumulation of Cd even at the 52 nd week [52][53]. Immunoreactivity of 5'MeC in the kidney of Cdtreated rats was markedly decreased at both early (the 20 th week, Fig.…”

Section: Global Dna Methylationmentioning

confidence: 80%

“…Immunoreactivity of 5'MeC in the kidney of Cdtreated rats was markedly decreased at both early (the 20 th week, Fig. (1A)) and the late (the 52 nd week) stages compared to the controls [52], along with an increased cell proliferation (Fig. 1B).…”

Section: Global Dna Methylationmentioning

confidence: 89%

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Cadmium and Its Epigenetic Effects

Wang

Shao³

et al. 2012

CMC

142

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Cadmium (Cd) is a toxic, nonessential transition metal and contributes a health risk to humans, including various cancers and cardiovascular diseases; however, underlying molecular mechanisms remain largely unknown. Cells transmit information to the next generation via two distinct ways: genetic and epigenetic. Chemical modifications to DNA or histone that alters the structure of chromatin without change of DNA nucleotide sequence are known as epigenetics. These heritable epigenetic changes include DNA methylation, post-translational modifications of histone tails (acetylation, methylation, phosphorylation, etc), and higher order packaging of DNA around nucleosomes. Apart from DNA methyltransferases, histone modification enzymes such as histone acetyltransferase, histone deacetylase, and methyltransferase, and microRNAs (miRNAs) all involve in these epigenetic changes. Recent studies indicate that Cd is able to induce various epigenetic changes in plant and mammalian cells in vitro and in vivo. Since aberrant epigenetics plays a critical role in the development of various cancers and chronic diseases, Cd may cause the above-mentioned pathogenic risks via epigenetic mechanisms. Here we review the in vitro and in vivo evidence of epigenetic effects of Cd. The available findings indicate that epigenetics occurred in association with Cd induction of malignant transformation of cells and pathological proliferation of tissues, suggesting that epigenetic effects may play a role in Cd toxic, particularly carcinogenic effects. The future of environmental epigenomic research on Cd should include the role of epigenetics in determining long-term and late-onset health effects following Cd exposure.

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Section: Effect Of CD On Dnmt Activitysupporting

confidence: 78%

Section: Mirnasupporting

confidence: 72%

Section: Global Dna Methylationmentioning

confidence: 80%

Section: Global Dna Methylationmentioning

confidence: 89%

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Cadmium and Its Epigenetic Effects

Wang

Shao³

et al. 2012

CMC

142

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“…Cd can also induce hematological and biochemical toxicity [9], hepatotoxicity [45], nephrotoxicity [41,42], neurotoxicity [44] and testotoxicity [24,30]. Furthermore, Cd can induce several toxic effects in newly born rat pups on lactational exposure [13].…”

Section: Introductionmentioning

confidence: 99%

The Protective Effect of Omega-3 Oil against Cadmium Chloride Induced Nephrotoxicity in Rat

Ismail¹,

Aziz²

2017

Cihan Univ.-Erbil Sci. J.

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The present study was designed to investigate the effect of cadmium (Cd), as cadmium chloride (CdCl2), on the kidney of male rats as well as the protective role of omega-3 oil against the Cd-induced histological, ultrastructural and immunohistochemical alterations. Thirty adult male rats were used in the present work, divided randomly into five groups, six rats in each. The first group was considered as control group and left without treatment except the standard rat chow and tap water. The second group was given (40 mg/ L) of CdCl2 in drinking water. The third group was given (60 mg/ L) of CdCl2 in drinking water. The fourth group was given (40 mg/L) of CdCl2 in drinking water plus omega-3 oil (4 gm/ kg diet) and the fifth group was given (60 mg/L) of CdCl2 in drinking water plus omega-3 oil (4 gm/ kg diet). All the above groups were left for 30days. Paraffin and plastic embedded methods were employed for the light microscopy study of the kidney in all treated animals and Immunohistochemical technique was applied to demonstrate apoptosis indicator protein (P53).Transmission electron microscopy preparations was employed for detection of further ultrastructural results. Kidney of CdCl2 treated groups has showed many histological change. These changes included dilation of the kidney tubules, degeneration of the cortical kidney tubule cells and the appearance of inflammatory leucocytes. Such changes have not been seen in the omega-3 plus both doses of CdCl2 groups. The transmission electron microscopy showed many ultrastructural changes, some of them were dilation of the vessels, highly affected podocytes, thickening of the basal lamina of the blood capillaries, lipid accumulation, degeneration of the microvilli of some proximal convoluted tubule cells and disruption of mitochondrial cristae.

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Effect of cadmium administration on the antioxidant system and neuronal death in the hippocampus of rats

Treviño

Pulido

Fuentes

et al. 2022

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Cadmium (Cd) is a heavy metal classified as a carcinogen whose exposure could affect the function of the central nervous system. Studies suggest that Cd modifies neuronal morphology in the hippocampus and affects cognitive tasks. The oxidative stress pathway is proposed as a mechanism of toxicity. However, this mechanism is not precise yet. This study aimed to evaluate the effect of Cd administration on oxidative stress markers in the male rat's hippocampus. Male Wistar rats were divided into (1) control (drinking water) and (2) treatment with Cd (32.5 ppm of cadmium chloride (CdCl2) in water). The Cd was administered for 2, 3, and 4 months. The results show that the oral administration of CdCl2 increased the concentration of Cd in plasma and hippocampus, and this response is time‐dependent on its administration. Likewise, it caused an increase in lipid peroxidation and nitrosative stress markers. Moreover, it increased reactive astrogliosis and antioxidant enzyme activity. Consequently, the progression of the oxidative response exacerbated neurodegeneration in hippocampal cells. Our results suggest that Cd exposure induces a severe oxidative response that contributes critically to hippocampal neurodegeneration. It is suggested that exposure to Cd increases the risk of developing neurological diseases, which contributes to a decrease in the quality of life of the human and the environment in which it lives.

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The Late and Persistent Pathogenic Effects of Cadmium at Very Low Levels on the Kidney of Rats

Cited by 21 publications

References 47 publications

Cadmium and Its Epigenetic Effects

Cadmium and Its Epigenetic Effects

The Protective Effect of Omega-3 Oil against Cadmium Chloride Induced Nephrotoxicity in Rat

Effect of cadmium administration on the antioxidant system and neuronal death in the hippocampus of rats

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