The late maintenance of hippocampal LTP: Requirements, phases, ‘synaptic tagging’, ‘late-associativity’ and implications

Reymann, Klaus G.; Frey, Julietta U.

doi:10.1016/j.neuropharm.2006.07.026

Cited by 298 publications

(283 citation statements)

References 123 publications

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“…Thus, Dudek and Fields have proposed that somatic action potential could activate gene expression and enable the cell-wide capture of L-LTP (Dudek and Fields, 2002). Also, neuromodulatory input, besides its role on modulation of synaptic processes, can play a major role in the activation of specific cascades of gene expression and facilitate synaptic plasticity changes in a cell-wide manner (Berke and Hyman, 2000;Reymann and Frey, 2007). Similar facilitatory effects have been also observed after enhancing CREB-dependent gene expression (Alarcon et al, 2006;Barco et al, 2002;Marie et al, 2005).…”

Section: Cell-wide Facilitation Modulation Of Intrinsic Excitabilitymentioning

confidence: 79%

“…The STC model added a second form of associativity in which heterosynaptic interactions can take place over a much longer time scale (Figure 2A), what has been called late-associativity (Reymann and Frey, 2007). Based on this model, the neuronal response to a particular stimulus would depend on the previous history of activation of the neuron not only in a range of milliseconds, but over minutes or even hours (Frey and Morris, 1998a).…”

Section: Accepted Manuscriptmentioning

confidence: 99%

“…Although we will describe mainly STC experiments performed on the Schaffer collateral pathway of the hippocampus of mice and rats, because this has become the prevalent model for these studies, we will also discuss results obtained in cultured Aplysia neurons and other model systems, which reveal the prevalence and universality of the cellular and molecular mechanisms underlying synapse-specific consolidation of LTP (see also other comments on the hypothesis in recent reviews by (Govindarajan et al, 2006;Morris, 2006;Reymann and Frey, 2007).…”

Section: Accepted Manuscriptmentioning

confidence: 99%

“…The STC hypothesis revisited 18 (Deng et al, 2007;Fuenzalida et al, 2007;Reymann and Frey, 2007;Zhang and Linden, 2003).…”

Section: Accepted Manuscriptmentioning

confidence: 99%

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Synapse-specific stabilization of plasticity processes: The synaptic tagging and capture hypothesis revisited 10 years later

Barco

Armentia

Alarcón

2008

Neuroscience & Biobehavioral Reviews

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Synapse-specific stabilization of plasticity processes: The synaptic tagging and capture hypothesis revisited ten years later, Neuroscience and Biobehavioral Reviews (2008Reviews ( ), doi:10.1016Reviews ( /j.neubiorev.2008 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.A c c e p t e d m a n u s c r i p t A c c e p t e d m a n u s c r i p tThe STC hypothesis revisited 2 Abstract A decade ago, the synaptic tagging hypothesis was proposed to explain how newly synthesized plasticity products can be specifically targeted to active synapses. A growing number of studies have validated the seminal findings that gave rise to this model, as well as contributed to unveil and expand the range of mechanisms underlying late-associativity and neuronal computation.Here, we will review what it was learnt during this past decade regarding the cellular and molecular mechanisms underlying synaptic tagging and synaptic capture. The accumulated experimental evidence has widened the theoretical framework set by the synaptic tagging and capture (STC) model and introduced concepts that were originally considered part of alternative models for explaining synapse-specific LTP. As a result, we believe that the STC model, now improved and expanded with these new ideas and concepts, still represents the most compelling hypothesis to explain late-associativity in synapse-specific plasticity processes. We will also discuss the impact of this model in our view of the integrative capability of neurons and associative learning. wordsKeywords: synaptic plasticity; LTP; associative learning; neuronal computation; synaptic tagging; synaptic capture; metaplasticity A c c e p t e d m a n u s c r i p tThe STC hypothesis revisited 3 Contents

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Section: Cell-wide Facilitation Modulation Of Intrinsic Excitabilitymentioning

confidence: 79%

Section: Accepted Manuscriptmentioning

confidence: 99%

Section: Accepted Manuscriptmentioning

confidence: 99%

“…The STC hypothesis revisited 18 (Deng et al, 2007;Fuenzalida et al, 2007;Reymann and Frey, 2007;Zhang and Linden, 2003).…”

Section: Accepted Manuscriptmentioning

confidence: 99%

See 2 more Smart Citations

Synapse-specific stabilization of plasticity processes: The synaptic tagging and capture hypothesis revisited 10 years later

Barco

Armentia

Alarcón

2008

Neuroscience & Biobehavioral Reviews

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“…Induction requires increased cytoplasmic calcium concentration to activate multiple signal transduction pathways, which increase synaptic strength. This leads to a sustained increase of the fEPSP (at least 30 mins; maintenance), the duration of which depends on the method of induction [33,34]. LTP induction can readily be inhibited, for example by Ca 2+ chelation or NMDA receptor inhibition [31].…”

Section: Introductionmentioning

confidence: 99%

Effects of relative hypoglycemia on LTP and NADH imaging in rat hippocampal slices

2007

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Cognitive and neuronal impairment in diabetes may be associated with iatrogenic hypoglycemia, particularly at low serum glucose levels (< 3 mM). To evaluate cellular impairment, we assessed acute hippocampal slice functioning during decreased ambient glucose, by monitoring evoked field excitatory post-synaptic potentials (fEPSP), and slice nicotinamide adenine dinucleotide (NADH) fluorescence. The effects of lowered glucose levels (60 min) were analyzed by examining the induction and maintenance of long-term potentiation (LTP), and NADH metabolic imaging in the CA1 region. The basal fEPSP response was reduced by lowered ambient glucose, an effect that was reversible in 2.5 mM glucose, partially reversible in 1.25 mM glucose and irreversible in 0 mM glucose, after 25 min recovery. LTP induction and maintenance declined during glucose restriction, demonstrating reversibly failed maintenance in 5 mM and 2.5 mM ambient glucose, and absent induction in 1.25 mM glucose. Peak NADH levels observed during train-induced biphasic transients were significantly reduced during 1.25 mM and 2.5 mM glucose. Significant functional compromise in our slice model occurred at 2.5 mM ambient glucose, equivalent to <1mM tissue glucose in the slice center, due to diffusion limitations and active glucose utilization. This tissue glucose level correlates with human observations of a serum threshold of <3mM for cognitive impairment, since brain tissue glucose is approximately one third of serum levels. The physiological effects of hypoglycemia in our slice model, assessed through fEPSP, LTP, and NADH responses, replicate closely the in vivo situation, confirming the usefulness of this model in assessing consequences of relative hypoglycemia.

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Transcranial Direct Current Stimulation: Modulation of Brain Pathways and Potential Clinical Applications

Nitsche¹,

Polanía²,

Kuo³

2015

Brain Stimulation

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The late maintenance of hippocampal LTP: Requirements, phases, ‘synaptic tagging’, ‘late-associativity’ and implications

Cited by 298 publications

References 123 publications

Synapse-specific stabilization of plasticity processes: The synaptic tagging and capture hypothesis revisited 10 years later

Synapse-specific stabilization of plasticity processes: The synaptic tagging and capture hypothesis revisited 10 years later

Effects of relative hypoglycemia on LTP and NADH imaging in rat hippocampal slices

Transcranial Direct Current Stimulation: Modulation of Brain Pathways and Potential Clinical Applications

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