The Le(a+b+) Phenotype in Polynesians

Henry, S.M.; Simpson, Lalita; Woodfield, D. G.

doi:10.1159/000153768

Cited by 31 publications

(17 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results of our study together with those of Henry et al [3] appear to indicate that the Le(a+b+) phenotype is almost ex clusive to populations of southeast Asia.…”

Section: Introductionsupporting

confidence: 86%

The Lewis Blood Group System among Chinese in Taiwan

Broadberry

Lin‐Chu²

1991

Hum Hered

View full text Add to dashboard Cite

The nonsecretor gene se is absent (or very rare) among Chinese in Taiwan and the previously reported Le(a+b–) phenotype in this population is in fact Le(a+b+) as proven by the presence of small amounts of Le^b antigen on red blood cells. Salivary ABH substances in this phenotype are usually (although not always) markedly reduced. The Chinese Le(a+b+) phenotype is postulated to be the result of a weak secretor gene Se^ω. Although the Le(a+b+) phenotype is very rare in Caucasians, it has a frequency of 25% in Chinese. All Le(a–b–) Chinese are ABH secretors and have varying amounts of Le^a and/or Le^b substances in saliva.

show abstract

“…The results of our study together with those of Henry et al [3] appear to indicate that the Le(a+b+) phenotype is almost ex clusive to populations of southeast Asia.…”

Section: Introductionsupporting

confidence: 86%

The Lewis Blood Group System among Chinese in Taiwan

Broadberry

Lin‐Chu²

1991

Hum Hered

View full text Add to dashboard Cite

show abstract

“…As participants of the 1990 workshop we used the monoclonal Lewis reagents supplied to further investigate the unusual phenotypes found in Polynesians [10,15,16], Previous results had suggested that there may be an Leb epitope common to all Polynesian Le(a-b+) individuals but not common to all Le(a+b+) individuals [15].…”

Section: Discussionmentioning

confidence: 99%

Plasma and Red-Cell Glycolipid Patterns of Le(a+b+) and Le(a+b-) Polynesians as Further Evidence of the Weak Secretor Gene Se^w

Henry¹,

Woodfield²,

Samuelsson³

et al. 1993

Vox Sanguinis

Self Cite

View full text Add to dashboard Cite

Monoclonal antibodies and thin-layer chromatography were used to study the unusual erythrocyte Lewis phenotypes found in healthy Polynesians. A single monoclonal anti-Le^b reagent 073 (clone LM129) was found which could detect Le^b antigen on the Polynesian erythrocytes of samples that were unreactive with various polyclonal and monoclonal anti-Le^b reagents. Glycolipid fractions prepared from the plasma and erythrocytes of selected Polynesian samples of red-cell Le(a-b-), Le(a+b-) and Le(a+b+) phenotypes were found to have Le^b glycolipids. The Le^b antigen in some individuals is so weakly expressed that it is undetectable by routine erythrocyte phenotyping. Unusually large glycolipids bearing the Le^b epitope were also found in some Polynesian samples, although the contribution of these novel glycolipids to phenotyping is unclear. The inability to detect Le^b by routine methods and the presence of novel structures can be partially explained in terms of the presence of a weak secretor gene Se^w.

show abstract

“…It was anticipated that if a weak secretor gene was present, it would result in reduced levels of ABH secretory substances. As group A persons exhibit the Le(a+b+) phenotype less frequently than group O individuals [3], the finding of group A Le(a-l-b-) red cells unable to express detectable Leb antigen, but with salivary ABH substances present would be expected.…”

Section: Introductionmentioning

confidence: 95%

“…Carefully controlled trials to determine the type and dilution of antisera that was able to define partial secretion of ABH substances were necessary [5,6]. Red cell and salivary ABH and Lewis phenotypes were deter mined in order to establish the existence of weak secretor phenotypes.…”

mentioning

confidence: 99%

Investigation of Lewis Phenotypes in Polynesians: Evidence of a Weak Secretor Phenotype

Henry

Benny

Woodfield³

1990

Vox Sanguinis

Self Cite

View full text Add to dashboard Cite

The salivary ABH and Lewis antigens of Polynesians were measured using a standardised red cell agglutination microplate assay and compared with the red cell defined Lewis phenotypes. Salivary ABH substances were detected in almost all saliva samples tested, with low levels (partial secretion) of ABH substances in the saliva from Le(a+b-) and Le(a+b+) individuals. Salivary Le^b substance was detected in all Le(a-b+) and Le(a+b+) samples and in almost all Le(a+b-) samples. It is evident from the results obtained that Polynesian red cell phenotypes cannot be used to predict the presence or absence of salivary substances. If the presence of a coding secretor gene is presumed responsible for salivary ABH antigens and salivary Le^b antigen expression, then the incidence of a coding secretor gene in Polynesians is 98%. These results indicate that the recessive non-secretor gene is absent or rare in a Polynesian derived gene pool. Two variants of secretor individuals are found among Polynesians, secretors with expression of normal amounts of the product of the secretor gene, similar to Caucasians, and partial secretors with weak expression of the secretor gene products.

show abstract

The Le(a+b+) Phenotype in Polynesians

Cited by 31 publications

References 8 publications

The Lewis Blood Group System among Chinese in Taiwan

The Lewis Blood Group System among Chinese in Taiwan

Plasma and Red-Cell Glycolipid Patterns of Le(a+b+) and Le(a+b-) Polynesians as Further Evidence of the Weak Secretor Gene Se^w

Investigation of Lewis Phenotypes in Polynesians: Evidence of a Weak Secretor Phenotype

Contact Info

Product

Resources

About