The Legislative Momentum of Antimicrobial Stewardship: An International Perspective

Vindenes, Tine; Beaulac, Kirthana; Doron, Shira

doi:10.1007/s40506-016-0072-x

Cited by 9 publications

(4 citation statements)

References 7 publications

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“…Previous studies found that ARGs and microorganisms were ubiquitous in environmental media, such as surface water, groundwater, and sediment, and were also detected in other media (Wang et al, 2021d;Szekeres et al, 2018;Lu et al, 2020). Studies have also shown that more than 700,000 people die from ARGs globally each year (Vindenes et al, 2016), and if not effectively addressed, the number of global deaths from ARGs is expected to reach 10 million in 2050, with the continued generation and spread of ARGs leading to a gradual reduction in the effectiveness of the corresponding antibiotic treatments (Rodriguez-Mozaz et al, 2015). Thus, the potential harm posed by antibiotics and ARGs in the environment has caused widespread global concern.…”

Section: Introductionmentioning

confidence: 98%

Characteristics of antibiotic resistance genes and microbial community distribution in Wanfeng Lake, upper Pearl River, China

Zhang

et al. 2023

Environ Sci Pollut Res

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Wanfeng Lake, a highland lake in the upper part of the Pearl River Basin, has long been disturbed by aquaculture and human activities, resulting in the accumulation of antibiotics and antibiotic resistance genes (ARGs), which pose a major threat to humans and animals.In this study, 20 antibiotics, 9 ARGs, 2 mobile genetic elements (intl1 and intl2) and microbial community structure were investigated in Wanfeng Lake. The results of the study showed that the total concentration of antibiotics in surface water was 372.72 ng/L, with o oxacin (OFX) having the highest concentration (169.48 ng/L), posing a high ecological risk to aquatic organisms. The total concentration of antibiotics in sediments was235.86 ng/g, with umequine (FLU) having the highest concentration (122.54 ng/g).Thisindicates that the main type of antibiotics in Wanfeng Lake are quinolones. Real-time uorescence quantitative PCR analysis results of the relative abundance of ARGs in both surface water and sediments showed that sulfonamide resistance genes > macrolide resistance genes > tetracycline resistance genes > quinolone resistance genes, indicating that sulfonamide resistance genes were the dominant type. The metagenomic results showed that the predominant microorganisms in the sediment under the phylum level were Planctomycetes, Proteobacteria, Euryarchaeota and Chloro exi. Pearson's correlation analysis showed a signi cantly positive correlation between antibiotics and environmental factors with ARGs in Wanfeng Lake and a signi cant positive correlation between antibiotics and ARGs with microorganisms in sediments. This suggests that there is a potential pressure of antibiotics on ARGs, while microorganisms provide the driving force for the evolution and spread of ARGs. This study provides a basis for further research on the occurrence and spread of antibiotics and ARGs in Wanfeng Lake.

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Section: Introductionmentioning

confidence: 98%

Characteristics of antibiotic resistance genes and microbial community distribution in Wanfeng Lake, upper Pearl River, China

Zhang

et al. 2023

Environ Sci Pollut Res

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“…A global call to stop the spread of antimicrobial resistance (AMR) has been set as a priority by the World Health Organization (WHO) and other global health institutions [ 1 , 2 , 3 , 4 ]. AMR is recognized as a global major public health threat, with 1.27 million deaths yearly caused directly by it, and 4.95 million deaths associated with bacterial AMR [ 1 ]; it is also acknowledged that estimates will exponentially increase in the future [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

“…In addition, the economic impact of this issue is projected to be USD 100 trillion or even higher if actions to prevent it are not taken soon [ 2 ]. Thus, antimicrobial stewardship (AMS) has risen within national and international action plans to combat AMR [ 4 ]. Important advances have been made in AMS strategies and antimicrobial stewardship programs (ASP), particularly in high-income countries (HICs) [ 6 , 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Stewardship Programs in Latin America and the Caribbean: A Story of Perseverance, Challenges, and Goals

Restrepo-Arbeláez,

Garcia-Betancur,

Pallares

et al. 2023

Antibiotics

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Antimicrobial resistance is one of the major global health threats. Antimicrobial stewardship (AMS) has been set as a priority within international action plans to combat this issue. The region of Latin America and the Caribbean are recognized for their high antimicrobial resistance rates; nevertheless, a low number of studies describing implemented interventions for this topic have been published. This review aims to provide an overview of the status of AMS in our region, focusing on the main progress achieved and describing the different published efforts made by countries towards the implementation of antimicrobial stewardship programs (ASP). Common areas of intervention included were (a) education approaches, (b) antimicrobial guideline implementation and monitoring, (c) diagnostic stewardship, (d) technological tools: electronic clinical decision support systems in AMS, (e) pharmacy-driven protocols and collaborative practice agreements, and (f) economic impact. The search demonstrated the varied interventions implemented in diverse healthcare settings; the results accentuate their influence on antimicrobial consumption, antimicrobial resistance, clinical outcomes, and direct economic impact. The integration of multiple strategies within each hospital was highlighted as an essential key to ASP success. Even though the literature found demonstrated clear progress, there is still a special need for strengthening leadership from the top down, defining goals based on needs, and gaining support through policy and financing in LAC.

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“…In different water bodies of the world, diverse ARGs correspond to macrolides, tetracyclines, quinolones, and sulfonamides (erm, tet, qnr, and sul, respectively) (Lee et al, 2017). The appearance of ARB and ARGs in water resources has caused a great concern due to the possibility of millions of deaths by 2050 (Vindenes et al, 2016). According to the Center for Disease Control (CDC) and the World Health Organization (WHO), ARGs in the environment are one of the most critical public health issues of this century (World Health Organization, 2018).…”

Section: Introductionmentioning

confidence: 99%

Elimination of antibiotic resistance genes and control of horizontal transfer risk by UV-based treatment of drinking water: A mini review

Sharma

McDonald

et al. 2019

Front. Environ. Sci. Eng.

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Antibiotic-resistant bacteria (ARB) and antibiotic resistance genes (ARGs) have been recognized as one of the biggest public health issues of the 21st century. Both ARB and ARGs have been determined in water after treatment with conventional disinfectants. Ultraviolet (UV) technology has been seen growth in application to disinfect the water. However, UV method alone is not adequate to degrade ARGs in water. Researchers are investigating the combination of UV with other oxidants (chlorine, hydrogen peroxide (H 2 O 2 ), peroxymonosulfate (PMS), and photocatalysts) to harness the high reactivity of produced reactive species (Cl•, ClO•, Cl 2 • − , •OH, and SO 4 • − ) in such processes with constituents of cell (e.g., deoxyribonucleic acid (DNA) and its components) in order to increase the degradation efficiency of ARGs. This paper briefly reviews the current status of different UV-based treatments (UV/chlorination, UV/H 2 O 2 , UV/PMS, and UV-photocatalysis) to degrade ARGs and to control horizontal gene transfer (HGT) in water. The review also provides discussion on the mechanism of degradation of ARGs and application of q-PCR and gel electrophoresis to obtain insights of the fate of ARGs during UV-based treatment processes.

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The Legislative Momentum of Antimicrobial Stewardship: An International Perspective

Cited by 9 publications

References 7 publications

Characteristics of antibiotic resistance genes and microbial community distribution in Wanfeng Lake, upper Pearl River, China

Characteristics of antibiotic resistance genes and microbial community distribution in Wanfeng Lake, upper Pearl River, China

Antimicrobial Stewardship Programs in Latin America and the Caribbean: A Story of Perseverance, Challenges, and Goals

Elimination of antibiotic resistance genes and control of horizontal transfer risk by UV-based treatment of drinking water: A mini review

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