The leucocyte disappearance reaction in non‐immune acute inflammation

Abstract

Injection of a variety of irritants (saline, ovalbumin, compound 48/80 and powdered glass) into the rat pleural cavity induced the disappearance of pleural leucocytes during the first two hours of the reaction. This phenomenon, termed the leucocyte disappearance reaction (LDR), was suppressed by treatment with the anticoagulants heparin and warfarin. The in-vitro incubation of normal, or inflammatory pleural leucocytes resulted in the deposition of dense interconnecting meshwork of fibrin only upon addition of fibrinogen to the culture medium. It is suggested from these results that the LDR is related to the clotting system, involving leucocyte-derived enzyme(s) analogous to those of the clotting system (e.g., tissue thromboplastin), which convert fibrogen to fibrin, resulting in cell-trapping and subsequent "disappearance" of pleural leuococytes. Similarities were observed betweeen the LDR in non-immune inflammation and the macrophage disappearance reaction of cell-mediated immunity. The significance of these phenomena in the inflammatory process, both immune and non-immune, is discussed.

Oncostatin M Receptor-β Signaling Limits Monocytic Cell Recruitment in Acute Inflammation

“…Before SES activation, the resident monocytic population was predominantly F4/80 high CD11b high . However, consistent with initial reports into the inflammatory trafficking of leukocytes within pleural cavities (27), SES stimulation triggered an early exodus of these cells from the peritoneal cavity, together with a marked influx of F4/ 80 low CD11b ϩ monocytic cells. However, as inflammation progressed (24 h), flow cytometry affirmed the re-emergence of a resident-like F4/80 high CD11b high population (Fig.…”

Pre/pro-B cells generate macrophage populations during homeostasis and inflammation

“…1B 5A). This latter population was phenotypically similar to pB-Mφ precursors in bone marrow and blood ( disappeared from the peritoneum, as is consistent with the "leukocyte disappearance phenomenon" (32), whereas the numbers of peritoneal pB-Mφ precursors increased at onset but declined from 24 to 72 h after zymosan injection (Fig. 5B).…”

Induction of macrophage DNA synthesis in vitro by non‐immunological inflammatory exudates: Effect of irradiation and thymus or bone marrow cell reconstitution

“…It may therefore be necessary to revise our views on the role of lymphocytes, and their products, in non-immune inflammation. Recent work by Sultan et al (1978) and Sultan et al (personal communication) support this concept since they have demonstrated that factors which are associated with lymphocytes and were hitherto considered specific for cell-mediated immune inflammation, may be released in non-immunologically induced acute inflammation.…”