The Level of Cholesterol in COPD Patients with Severe and Very Severe Stage of the Disease

Zafirova-Ivanovska, Beti; Stojkovikj, Jagoda; Dokikj, Dejan; Anastasova, Sasha; Debresliovska, Angela; Zejnel, Sead; Stojkovikj, Dragana

doi:10.3889/oamjms.2016.063

Cited by 20 publications

(27 citation statements)

References 22 publications

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“…Ivanovska 28 reported that total cholesterol and LDLcholesterol levels of severe COPD patients were significantly higher, which is different from the results of this study. Fasting blood glucose and HbA1c was greater in the COPD group than the NCOPD group, and both groups were pre-diabetic.…”

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confidence: 99%

Nutrient intake and dietary quality of Korean adults according to chronic obstructive pulmonary disease (COPD): Based on the 2012~2014 Korea National Health and Nutrition Examination Survey

et al. 2017

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Purpose: Food intake of COPD patients decreases because of appetite loss, depression, and breathing problems while eating, which increase the likelihood of patients becoming malnourished. This study investigated the nutrient intake and dietary quality of people with and without COPD in Korea. Methods: There were 2,160 adults aged 50 and over who participated in the 5~6 th Korea National Health and Nutrition Examination Survey. The subjects were divided into the COPD group and non-COPD group according to the rate of forced expiratory volume at 1 second (FEV1) against forced vital capacity (FVC). Consumption of food and nutrients were calculated based on the nutrition examination survey. Statistical analyses were conducted using SPSS 19.0. Results: Among individuals in their 50s, intake of vitamin B1 in the COPD group was significantly less than the NCOPD group, while intake of sodium in the COPD group was significantly greater than the NCOPD group. Among individuals in their 60s, the energy intake of the COPD group was significantly less than that of the NCOPD group. The COPD group showed significantly less intake of vitamin B1 and vitamin C, but greater intake of sodium than the NCOPD group. In the group aged 70 and over, The COPD group had significantly less intake of vitamin B1 than the NCOPD group and showed lower nutrient adequacy ratio values in protein, vitamin B1, vitamin B2, and iron than the NCOPD group. Conclusion: The COPD group consumed less energy and certain nutrients, and their dietary quality was poor compared to the NCOPD group. Thus, more detailed research is required to understand the concrete relationship between COPD and malnutrition.

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confidence: 99%

Nutrient intake and dietary quality of Korean adults according to chronic obstructive pulmonary disease (COPD): Based on the 2012~2014 Korea National Health and Nutrition Examination Survey

et al. 2017

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“…Consequently, the level of cholesterol was high in the severe stage COPD patients, which may due to their life style modifications, such as restricted diet, poor lung function and ex-smoker status. 4,16 In present study, high triglycerides, low HDL cholesterol, and high LDL cholesterol, and low TCH were observed, especially in severe stage in comparison to moderate stage of COPD patients; however, these values were statistically significant in HDL and LDL parameters among COPD, moderate and severe stages.…”

Section: Discussioncontrasting

confidence: 54%

“…The occurrence of COPD in India is 4.1%. 3,4,5 In patients with COPD, smoking is considered as main risk factor. Various studies have concluded disarrangement of lipoprotein parameters as effects of tobacco smoking.…”

Section: Introductionmentioning

confidence: 99%

To Estimate Lipid Profile in Patients With Copd

Mahajan

Ambad

Jha

et al. 2020

IJMBS

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Background: Chronic Obstructive Pulmonary Disease (COPD) includes persistent bronchitis and emphysema, which is generally caused due to smoking of tobacco. (COPD) is an obstructive lung disorder characterized by airflow limitation that is progressive, associated with severe inflammatory response in the air passages and the lungs due to toxic particles. It interferes with normal breathing and is not fully reversible. Objectives: 1. To estimate lipid profile (Total cholesterol (TCH), Triglycerides (TG), High density lipoprotein (HDL), Low density lipoprotein (LDL), Very low-density lipoprotein (VLDL)) in patients with Chronic Obstructive Pulmonary. 2. To find correlation of these parameters with severity of disease. Material and Method: The study was conducted in Department of Biochemistry in collaboration with Department of Respiratory Medicine at Jawaharlal Nehru Medical College and AVBRH, Sawangi (Meghe) Wardha, India. Thirty-two patients diagnosed with COPD were selected from OPD and ward of Respiratory Medicine and thirty-two age and sex matched controls were taken. Result: The analysis of total cholesterol, triglycerides, HDL, LDL, VLDL in cases and controls. Result was statistically significant in between cases and controls of total cholesterol (p<0.001), HDL (p<0.001) and LDL (p<0.001), and statistically not significant in between cases and controls of triglycerides (p=0.6) and VLDL (p=0.98). Conclusion: We conclude that smoking significantly affect lipid profile in COPD patients, as it increases LDL levels and decreases HDL levels. Hence all patients with COPD patients who are smoker’s needs to check their lipid profile. COPD is considered as systemic disease with various co morbidities, which may affect the lipid profile. Keywords: Lipid profile, COPD, AAT, CVD, TNF-α, CRP and GOLD.

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“…Moreover, 8 of the ratios of glycerophospholipids to cholesterol ester were lower in COPD groups, while the rest 2 lipid ratios biomarkers were higher in COPD groups. Patients with severe COPD have a higher level of cholesterol in the blood [ 33 ]. The upregulation of cholesterol could be partially due to the adverse effects of cigarette smoking on lipoprotein regulation [ 34 – 37 ].…”

Section: Resultsmentioning

confidence: 99%

“…Consistent with previous data [ 66 ], the major format of cholesterol ester is C18:2 CE as shown in Supplemental Table 1 . Patients with very severe COPD have a much higher level of cholesterol [ 33 , 35 ]. Interestingly, our results indicated the ratio of C16:1 CE in patients with COPD is about 3 times higher than that in healthy controls.…”

Section: Discussionmentioning

confidence: 99%

Identification of lipid biomarker from serum in patients with chronic obstructive pulmonary disease

et al. 2020

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Background Chronic obstructive pulmonary disease (COPD) is the third leading cause of death in the United States with no effective treatment. The current diagnostic method, spirometry, does not accurately reflect the severity of COPD disease status. Therefore, there is a pressing unmet medical need to develop noninvasive methods and reliable biomarkers to detect early stages of COPD. Lipids are the fundamental components of cell membranes, and dysregulation of lipids was proven to be associated with COPD. Lipidomics is a comprehensive approach to all the pathways and networks of cellular lipids in biological systems. It is widely used for disease diagnosis, biomarker identification, and pathology disorders detection relating to lipid metabolism. Methods In the current study, a total of 25 serum samples were collected from 5 normal control subjects and 20 patients with different stages of COPD according to the global initiative for chronic obstructive lung disease (GOLD) (GOLD stages I ~ IV, 5 patients per group). After metabolite extraction, lipidomic analysis was performed using electrospray ionization mass spectrometry (ESI-MS) to detect the serum lipid species. Later, the comparisons of individual lipids were performed between controls and patients with COPD. Orthogonal projections to latent structures discriminant analysis (OPLS-DA) and receiver operating characteristic (ROC) analysis were utilized to test the potential biomarkers. Finally, correlations between the validated lipidomic biomarkers and disease stages, age, FEV1% pack years and BMI were evaluated. Results Our results indicate that a panel of 50 lipid metabolites including phospholipids, sphingolipids, glycerolipids, and cholesterol esters can be used to differentiate the presence of COPD. Among them, 10 individual lipid species showed significance (p < 0.05) with a two-fold change. In addition, lipid ratios between every two lipid species were also evaluated as potential biomarkers. Further multivariate data analysis and receiver operating characteristic (ROC: 0.83 ~ 0.99) analysis suggest that four lipid species (AUC:0.86 ~ 0.95) and ten lipid ratios could be potential biomarkers for COPD (AUC:0.94 ~ 1) with higher sensitivity and specificity. Further correlation analyses indicate these potential biomarkers were not affected age, BMI, stages and FEV1%, but were associated with smoking pack years. Conclusion Using lipidomics and statistical methods, we identified unique lipid signatures as potential biomarkers for diagnosis of COPD. Further validation studies of these potential biomarkers with large population may elucidate their roles in the development of COPD.

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The Level of Cholesterol in COPD Patients with Severe and Very Severe Stage of the Disease

Cited by 20 publications

References 22 publications

Nutrient intake and dietary quality of Korean adults according to chronic obstructive pulmonary disease (COPD): Based on the 2012~2014 Korea National Health and Nutrition Examination Survey

Nutrient intake and dietary quality of Korean adults according to chronic obstructive pulmonary disease (COPD): Based on the 2012~2014 Korea National Health and Nutrition Examination Survey

To Estimate Lipid Profile in Patients With Copd

Identification of lipid biomarker from serum in patients with chronic obstructive pulmonary disease

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