The level of serotonin and its metabolite in hemolytic-uremic syndrome in children

Abstract

Hemolytic-uremic syndrome includes a triad of symptoms: microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury. Given the progressive course of hemolytic-uremic syndrome, up to the terminal stage of renal failure, it is necessary to search for early markers of renal tissue damage as prognostically significant factors in the development of nephrosclerosis, which is of particular importance in childhood to optimize the management of such patients. The analysis of the literature data demonstrates the actual role of serotonin and platelet-mediated effect of serotonin on fibroinflammatory processes in kidney vessels. Thus, changes in the serotonergic system in patients already at the onset of hemolytic-uremic syndrome are of great interest in order to develop new diagnostic approaches that allow optimizing early diagnosis and slowing down the progression of renal damage in this category of patients. These studies will expand knowledge about the role of the serotonergic system in the formation of chronic kidney disease in children with hemolytic-uremic syndrome.