The Level of Serum C-Reactive Protein and Neutrophil Lymphocyte Ratio According to Thyroid Function Status

Abstract

Objective: We aimed to investigate neutrophil lymphocyte ratio (NLR), leukocyte count (WBC), mean platelet volume (MPV) and C-reactive protein levels (CRP) as inflammatory markers according to thyroid function status in hypo-hyperthyroidism patients.Methods: Data of patients (n=454, age>18) who applied to the Eskisehir Osmangazi University Hospital between March 2018 and December 2018 were evaluated retrospectively. There were 79 patients in hyperthyroidism group (TSH<0.27 µIU/ml, group I), 297 patients in euthyroid group (TSH=0.27-4.2 µIU/ml, group II) and 78 patients in hypothyroidism group (TSH>4.2 µIU/ml, group III).Results: Serum TSH, fT4, fT3, anti-TG and anti-TPO levels were found statistically different between groups (p<0.001) but there were no significant difference in WBC, NLR and MPV between groups. There was a positive correlation between the NLR and CRP (r=0,295, p<0.01). In addition, NLR was positively correlated with WBC (r=0,412, p<0.001). Serum CRP levels were statistically higher in group I (3.5 mg/L [1.50-11]) than group II (2.1 mg/L [0.86-5.42]), (p<0.001). Although CRP levels were higher in group III (2.5 mg/L [1.18-5.73]) than group II, there was no significant difference. CRP showed weak positive correlation with fT4 (r=0,118, p<0.05) and negative correlation with TSH (r=-0,108, p<0.05). Conclusion:High CRP levels may play an important role in the evaluation of hyperthyroidism in terms of thyroid dysfunction observed in the present study.

Relationship between Neutrophil-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio, and Hyperhomocysteinemia in Patients with Ischemic Stroke: A Proof-of-Concept Randomized Trial

“…Therefore, our study complements the role of NLR and PLR in cerebrovascular diseases and provides new ideas for clinical practice. NLR is considered an emerging marker between the immune system and disease including IS and thyroid function dysfunction [32,33]; the results of our study are a further proof underscoring the involvement of immune system in the pathogenetic chain of IS. A previous study showed inconsistent trends in NLR and CRP levels in patients with COVID-19 [34], whereas our study found that both NLR and CRP levels increased simultaneously in IS-related HHCY patients, This may be due to COVID-19 patients being infected by the novel corona virus.…”

Prevalence of Thyroid disorders in Nasiriya City, Iraq

“…A study published by Faith and his colleagues demonstrated a significant difference in TSH levels between hypothyroidism and hyperthyroidism groups [33]. Table (4) 125 shows the statistical relationship between the patients and the healthy groups in TSH levels.…”

Thyroid Gland Disease as a Comorbid Condition in COPD

“…There is a widespread perception that increased inflammation in COPD causes a decrease in TSH level by affecting the pituitary gland and also reduces the formation of fT3 from fT4. Kar et al [16] reported a significant negative correlation between CRP and TSH (r = −0:108, p < 0:05), although in a study which included 190 subjects, Lee et al declared that there was no significant relationship between CRP and TSH [17].…”