The levels of glutathione and hemoglobin in sheep erythrocytes as a function of age

Abstract

The behaviour of the levels of glutathione (GSH) and hemoglobin (Hb) was studied in blood samples from 126 one- to<br />seven-year-old sheep reared in the province of Salerno, Italy. Negative and significant correlation with age both for<br />hemoglobin and glutathione has been reported. A significant difference, on the basis of age, is evidenced only in males<br />(n=24) for Hb (P = 0.001) and only in females (n=102) for GSH (P = 0.001). These results indicate a greater presence<br />of Hb in young sheep and a greater demand for GSH in adult sheep. Moreover, the lowering of GSH and Hb with respect<br />to age may have caused a reduction of the organism defense to environmental stress factors. Therefore, it would be useful,<br />at least in productive animals, to use feed with a high content of polyphenolic compounds that increase the GSH concentration.<br />The aim of the present work was to study the behaviour of the levels of glutathione and hemoglobin in sheep at different<br />ages

Haematological and serum biochemical values of southern chamois (Rupicapra pyrenaica)

“…The serum chloride concentration can vary with an animal's hydration status and blood acid-base balance (Carlson 1997); the higher values observed in summer in the adult male chamois than in the yearlings may have been related to their different habitats and diets (Catusse and others 1996). The higher concentrations of bilirubin, lactate, creatinine, urea, chloride and α 2 -globulins observed in the adult males than in the yearling males may also have been due, at least partially, to the greater susceptibility of the adults to the effects of stress during capture, because adult animals tend to be less restricted physi-ologically to stress than younger animals (Annunziata and Iorio 2004).…”

Immunomodulatory effects of silymarin after subacute exposure to mice: A tiered approach immunotoxicity screening

“…In normal circumstances the interaction of lymphocytes with antigens and other cell subsets needs the cell membrane integrity. Lower levels of intracellular antioxidants such as GSH in T-cells make them more susceptible to lipid peroxidation [ 31 , 32 ]. Therefore in our study, silymarin at lower doses (50 and 100 mg/kg) may have acted as a potent antioxidant to remove any additional ROS that could partake in the disruption of T-cells membrane fluidity, ultimately resulting in overall immunostimulation.…”