The levels of steroid hormones and cytokines in individual follicles are not associated with the fertilization outcome after intracytoplasmic sperm injection

Asimakopoulos, Byron; Abu-Hassan, D; Metzen, Eric; Al‐Hasani, S.; Diedrich, K.; Nikolettos, Nikos

doi:10.1016/j.fertnstert.2007.05.054

Cited by 36 publications

(34 citation statements)

References 31 publications

(29 reference statements)

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“…2 Positive correlation between FF IL-6 and serum estradiol level on the day of hCG administration in IVF cycles; shaded area identifies 95% CI for the data IL-6 levels play a causative role in ovarian steroidogenesis, as has been previously suggested, these observations may partly explain the hyperestrogenemic milieu of reproductive aging, as has been previously described [32]. FF levels of IL-6 were unrelated to COH protocol or fertilization rates and in this context our findings are consistent with published data [33,34]. Given our study design where FF samples were pooled for each patient, we cannot relate FF IL-6 with individual oocytes within each follicle; the linear relationship observed between FF IL-6 and yield of mature oocytes however, is supportive of previously published work by Kawasaki et al [25]; these authors described higher IL-6 levels in fluid from follicles yielding mature oocytes.…”

Section: Discussionsupporting

confidence: 92%

Low follicular fluid IL-6 levels in IVF patients are associated with increased likelihood of clinical pregnancy

Altun

Jindal

Greenseid

et al. 2010

J Assist Reprod Genet

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Section: Discussionsupporting

confidence: 92%

Low follicular fluid IL-6 levels in IVF patients are associated with increased likelihood of clinical pregnancy

Altun

Jindal

Greenseid

et al. 2010

J Assist Reprod Genet

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“…did not find an association between hormone levels of follicular estradiol or progesterone and embryo quality. [13]…”

Section: Discussionmentioning

confidence: 99%

“…[101112] These observations, however, have not been confirmed by other studies. [1314] The embryo quality was not related to levels of follicular estradiol and progesterone. [13] Regarding pregnancy rates, both elevated estradiol and progesterone levels in follicular fluid were associated with an increased chance of pregnancy.…”

Section: Introductionmentioning

confidence: 99%

Follicular steroid hormones as markers of oocyte quality and oocyte development potential

et al. 2014

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CONTEXT:Various components of follicular fluid are suggested as biochemical predictors of oocyte quality. Previous studies of follicular steroid hormone levels have shown disparate results when related with fertilization outcomes.AIM:The objective of the study was to relate the levels of steroid hormones of each individual follicle with oocyte maturation, fertilization results, embryo quality, and pregnancy rates.SETTINGS AND DESIGN:Prospective cohort study in a university hospital.METHODS:In 31 patients, who underwent intracytoplasmic sperm injection, it was performed an ultrasound guided aspiration of follicular fluid of the first two mature follicles from each ovary. Follicular levels of estradiol, progesterone, testosterone, and dehydroepiandrosterone sulfate were measured by chemiluminescent immunoassay.STATISTICAL ANALYSIS:Generalized estimating equation model.RESULTS:In follicular fluids with mature oocyte presence, in normal as well as in failed fertilization, there was a positive correlation between follicular testosterone and progesterone (r = 0.794, P = 0.0001 and r = 0.829, P = 0.0001). Progesterone levels were higher in cases of normal fertilization compared to failed fertilization (P = 0.003). B quality embryos came from oocytes immersed in follicular fluids with higher estradiol values and higher estradiol/progesterone and estradiol/testosterone ratios than those of C quality (P = 0.01; P = 0.0009; P = 0.001). Estradiol levels were higher in patients who achieved pregnancy (P = 0.02).CONCLUSION:The analysis of follicular hormone composition could be considered as an additional tool in oocyte selection.

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“…Macrophages seem to play key roles in these processes [26]. Many studies conducted with women following controlled ovarian hyperstimulation have documented the presence of proinflammatory cytokines in follicles at the time of ovulation [27][28][29][30][31][32][33]. on the other hand, it is known that leptin exerts pro-inflammatory actions: it is produced by inflammatory cells, its secretion is increased by inflammatory stimuli such as iL-1, iL-6 and lipopolysaccharide (Lps), whereas it modulates white blood cells [4].…”

Section: Discussionmentioning

confidence: 99%

Serum Pattern of Circulating Adipokines throughout the Physiological Menstrual Cycle

et al. 2009

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During the last decade, studies provided evidence on the indirect or direct participation of leptin in human reproductive functions. Leptin plays a role in puberty, gonadal function, early embryogenesis and fat metabolism during pregnancy [5][6][7]. Mean circulating leptin levels are higher in women compared to men [5][6][7]. At the same time, circulating leptin levels vary during the physiological spontaneous menstrual cycle presenting with lower values during the follicular and higher values during the luteal phase [8][9][10][11][12][13]. This fact supports the notion that leptin plays an important role in female reproductive functions and it fuels questions whether leptin levels are associated with gonadotropin or ovarian steroid levels. These questions still remain open.The participation of leptin in human female reproductive functions raises the question whether other adipokines are related to these functions, too. The present study was designed to investigate the serum levels of Byron AsiMAkopouLos*, AthAnAsios MiLousis*, theodorA GiokA**, GeorGiA kABouRoMiTi**, GeorGe GiAnissLis*, Androniki TRoussA*, MArA siMopouLou*, siMoni kATeRGARi*, GreGory TRipsiAnis*, nikos nikoLeTTos*** Abstract. This study investigated the serum levels of resistin, adiponectin and leptin during the physiological menstrual cycle. sixteen women (age: 19-30 years; body mass index: 19.46-24.9) with regular menstrual cycles participated. Fasting blood samples were collected on alternate days throughout a full menstrual cycle. Mean resistin concentrations were slightly higher during the luteal phase (5.30±0.23 ng/ml) compared to the follicular (4.68±0.07 ng/ml) and midcycle (4.86±0.09 ng/ml) phases (p=0.032). Mean leptin concentrations during the follicular phase (18.14±0.28 ng/ml) were significantly lower compared to the midcycle (21.79±0.29 ng/ml, p=0.006) and luteal phases (23.75±0.64 ng/ml, p<0.001). The variation of adiponectin concentrations throughout the menstrual cycle was not significant. According to the results, circulating resistin, likewise leptin concentrations vary significantly during the physiological menstrual cycle presenting with higher values during the luteal phase. This pattern, although its physiological importance is not clear, suggests that resistin, likewise to leptin, may have a role in the regulation of cyclic female reproductive functions. The stable adiponectin concentrations throughout the menstrual cycle indicate that this adipokine probably does not play a considerable role in female reproductive functions.

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The levels of steroid hormones and cytokines in individual follicles are not associated with the fertilization outcome after intracytoplasmic sperm injection

Cited by 36 publications

References 31 publications

Low follicular fluid IL-6 levels in IVF patients are associated with increased likelihood of clinical pregnancy

Low follicular fluid IL-6 levels in IVF patients are associated with increased likelihood of clinical pregnancy

Follicular steroid hormones as markers of oocyte quality and oocyte development potential

Serum Pattern of Circulating Adipokines throughout the Physiological Menstrual Cycle

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