The lignan eudesmin extracted from Piper truncatum induced vascular relaxation via activation of endothelial histamine H1 receptors

Raimundo, Juliana Montani; Trindade, Ana Paula Felix; Velozo, Leosvaldo S. M.; Kaplan, Maria Auxiliadora Coelho; Sudo, Roberto T.; Zapata‐Sudo, Gisele

doi:10.1016/j.ejphar.2009.01.038

Cited by 22 publications

(20 citation statements)

References 33 publications

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“…Besides NO, prostacyclin release from endothelium possibly prompts smooth muscle relaxation via the adenylate cyclase pathway (Parkington et al, 2004), but in this case pretreatment with indomethacin failed to modify (-)-cubebin-induced relaxation, suggesting that prostanoids did not contribute to the relaxant effect. The reported results are in agreement with the work of Raimundo et al (2009), who showed that the vasodilating effect induced by eudesmin, a lignan from Piper truncatum, involved a mechanism dependent on the endothelium-derived relaxant factor NO, including cGMP. These authors also gave evidence of the participation of prostanoids (Raimundo et al, 2009).…”

Section: Discussionsupporting

confidence: 92%

“…(), who showed that the vasodilating effect induced by eudesmin, a lignan from Piper truncatum , involved a mechanism dependent on the endothelium‐derived relaxant factor NO, including cGMP. These authors also gave evidence of the participation of prostanoids (Raimundo et al ., ). Gomisin A (GA) is a low‐molecular‐weight lignan from Schisandra chinensis , a member of the Magnoliaceae family.…”

Section: Discussionmentioning

confidence: 99%

“…Among such metabolites are flavonoids, tannins as well as lignans, that are phenolic compound, which may directly activate NO formation from endothelial NO synthase or may enhance NO-mediated relaxation by superoxide anions scavenging (Achike and Kwan, 2003). Eudesmin, the main lignan of the hexane extract from Piper truncatem leaves, promotes NO-and prostanoid-mediated rat aorta vascular relaxation (Raimundo et al, 2009). However, the effect of (-)-cubebin on vascular reactivity has not yet been tested.…”

Section: Introductionmentioning

confidence: 99%

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The Lignan (‐)‐Cubebin Inhibits Vascular Contraction and Induces Relaxation Via Nitric Oxide Activation in Isolated Rat Aorta

Carvalho

Rezende

Évora

et al. 2013

Phytotherapy Research

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Cubebin, the most abundant lignan in Piper cubeba, has been described as having several effects as trypanocidal, antimycobacterial, antispasmodic, antimicrobial, anti-inflammatory, and analgesic. This study investigated the vasorelaxant effect produced by (-)-cubebin in isolated rat aortic rings pre-contracted with phenylephrine (Phe), and the possible mechanism involved in this event was evaluated. Endothelium-dependent relaxation was evoked by acetylcholine and (-)-cubebin in intact aortic rings, while endothelium-independent vasorelaxation was elicited by sodium nitroprusside and (-)-cubebin in denuded rings. Cumulative concentration-response curves for Phe (10(-10) -10(-5) M) were determined for endothelium-intact and endothelium-denuded aortic rings in either the presence or absence of (-)-cubebin. Dose-response curves were also constructed for pre-incubation of vascular rings with Nω-nitro-L-arginine methyl ester (L-NAME) (a non-specific nitric oxide synthase inhibitor), indomethacin (an unspecific cyclooxygenase inhibitor), and 1H-[1,2,4] oxadiazolo [4,3-a]quinoxalin-1-one (ODQ) (a guanylyl cyclase inhibitor). (-)-Cubebin was found to exert a vasorelaxant effect irrespective of the presence of endothelium, which was abolished by pretreatment with L-NAME and ODQ, but not with indomethacin. In addition, (-)-cubebin was able to reduce Phe contraction in the case of intact rings. These results suggest that (-)-cubebin promotes vasorelaxation via NO/cGMP pathway in rat aorta, without prostacyclin involvement.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Lignan (‐)‐Cubebin Inhibits Vascular Contraction and Induces Relaxation Via Nitric Oxide Activation in Isolated Rat Aorta

Carvalho

Rezende

Évora

et al. 2013

Phytotherapy Research

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“…Although the auricular nerve is a peripheral mixed nerve, ES on the dissected fasciculus could still slow the outflow from the perfused rabbit ear, an effect that can be significantly blocked by 1×10 -5 mol/L prazosin ( Factors responsible for the differences in the effects of CPM and cimetidine are the density, the affinity and the location of histamine receptors. Since it has been reported that vasodilation could be mediated by NO and prostanoid signaling pathways through activation of endothelial histamine H 1 receptors [15,16] , it appears that the neurogenic histamineinduced vasoconstriction is associated with activation of smooth muscle H 1 receptors, whereas the vasodilatation is mediated by smooth muscle H 2 receptors. However, further…”

Section: Discussionmentioning

confidence: 99%

Effects of sympathetic histamine on vasomotor responses of blood vessels in rabbit ear to electrical stimulation

et al. 2010

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“…Several studies related to the phytochemistry of the Piper species have shown some bioactive metabolites including alkaloids, chromenes, amides, flavonoids and terpenoids. Many of these metabolites have economical and medicinal value (Lara Junior et al 2012, Marques et al 2010, Moraes et al 2011, Parmar et al 1997, Raimundo et al 2009, Rebelo et al 2012, Silva et al 2010). …”

Section: Larvicidal Properties Of Crude Extracts and Sub-fractions Ofmentioning

confidence: 99%

Active metabolites of the genus Piper against Aedes aegypti: natural alternative sources for dengue vector control

Marques

Kaplan²

2014

Univ. Sci.

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The mosquito, Aedes aegypti, is the principal vector of the viruses responsible for dengue and dengue hemorrhagic fevers. The mosquito is widespread throughout tropical and sub-tropical regions; its prevalence makes dengue one of the most important mosquito-borne viral diseases in the world occurring annually in more than 100 endemic countries. Because blood is essential to their development cycle, the Aedes species maintains a close association with humans and their dwellings. Fittingly, the most widely adopted strategy to decrease the incidence of these diseases is the control of the mosquito larvae population. The emergence of insecticide-resistant mosquitoes has amplified the interest in finding natural products effective against Aedes aegypti adults, as well as larvae. Plantderived compounds have played an important role in the discovery of new active entities for vector management as they are safer and have lower toxicity to humans in comparison to conventional insecticides. This review assesses a naturally occurring plant matrix and pure compounds of the Piper species, which have been shown to be active against Aedes aegypti.

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The lignan eudesmin extracted from Piper truncatum induced vascular relaxation via activation of endothelial histamine H1 receptors

Cited by 22 publications

References 33 publications

The Lignan (‐)‐Cubebin Inhibits Vascular Contraction and Induces Relaxation Via Nitric Oxide Activation in Isolated Rat Aorta

The Lignan (‐)‐Cubebin Inhibits Vascular Contraction and Induces Relaxation Via Nitric Oxide Activation in Isolated Rat Aorta

Effects of sympathetic histamine on vasomotor responses of blood vessels in rabbit ear to electrical stimulation

Active metabolites of the genus Piper against Aedes aegypti: natural alternative sources for dengue vector control

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