The link between chronic obstructive pulmonary disease phenotypes and histological subtypes of lung cancer: a case&amp;ndash;control study

Wang, Wei; Xie, Mengshuang; Dou, Shuang; Cui, Liwei; Zheng, Chunyan; Xiao, Wei

doi:10.2147/copd.s158818

Cited by 26 publications

(12 citation statements)

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“…Patients with emphysematous lungs had a higher prevalence of male sex and a smoking history [12, 14]. Regarding histology, emphysema lung was associated with a risk of small cell lung carcinoma (SCLC) and squamous cell carcinoma [28, 29]. In the present study, male sex, thinner patients, higher smoking index, squamous cell carcinoma, high histologic grade, and pleural invasion-positive were more frequent in patients with emphysema, similar to previous reports.…”

Section: Discussionmentioning

confidence: 99%

The impact of emphysema on surgical outcomes of early-stage lung cancer: a retrospective study

et al. 2019

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Background The presence of emphysema on computed tomography (CT) is associated with an increased frequency of lung cancer, but the postoperative outcomes of patients with pulmonary emphysema are not well known. The objective of this study was to investigate the association between the extent of emphysema and long-term outcomes, as well as mortality and postoperative complications, in early-stage lung cancer patients after pulmonary resection. Methods The clinical records of 566 consecutive lung cancer patients who underwent pulmonary resection in our department were retrospectively reviewed. Among these, the data sets of 364 pathological stage I patients were available. The associations between the extent of lung emphysema and long-term outcomes and postoperative complications were investigated. Emphysema was assessed on the basis of semiquantitative CT. Surgery-related complications of Grade ≥ II according to the Clavien-Dindo classification were included in this study. Results Emphysema was present in 63 patients. The overall survival and relapse-free survival of the non-emphysema and emphysema groups at 5 years were 89.0 and 61.3% ( P < 0.001), respectively, and 81.0 and 51.7%, respectively ( P < 0.001). On multivariate analysis, significant prognostic factors were emphysema, higher smoking index, and higher histologic grade ( p < 0.05). Significant risk factors for poor recurrence-free survival were emphysema, higher smoking index, higher histologic grade, and presence of pleural invasion ( P < 0.05). Regarding Grade ≥ II postoperative complications, pneumonia and supraventricular tachycardia were more frequent in the emphysema group than in the non-emphysema group ( P = 0.003 and P = 0.021, respectively). Conclusion The presence of emphysema affects the long-term outcomes and the development of postoperative complications in early-stage lung cancer patients.

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Section: Discussionmentioning

confidence: 99%

The impact of emphysema on surgical outcomes of early-stage lung cancer: a retrospective study

et al. 2019

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“…However, FZR1, but not MTA1 and PKMYT1, was validated to be Introduction Chronic obstructive pulmonary disease (COPD) and lung cancer are common causes of death worldwide. 1 Previous studies reported COPD was more likely to develop lung cancer than those with normal lung function, [2][3][4][5] indicating COPD is an independent risk factor for lung cancer, 3,[6][7][8] which may result in co-existing of COPD and lung cancer. In this process, genetic susceptibility is one of the welldescribed mechanisms for co-existing of COPD and lung cancer.…”

Section: What Is Added To This Topic?mentioning

confidence: 99%

Identification of Susceptible Genes for Chronic Obstructive Pulmonary Disease with Lung Adenocarcinoma by Weighted Gene Co-Expression Network Analysis

Wang

et al. 2021

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Purpose Chronic obstructive pulmonary disease (COPD) and lung adenocarcinoma (LUAD) are common disorders and usually co-exists. However, genetic mechanisms between COPD and LUAD are rarely reported. This study aims to identify susceptible genes of COPD with LUAD. Methods Using the published data of GSE106899, co-expression modules were constructed by weighted gene co-expression network analysis (WGCNA). Subsequently, top 50 genes in the most tumor-related module were identified, among which hub genes were selected and validated. Results Twenty co-expression modules were constructed on 13,865 genes from 62 lung tissues of COPD patients with or without LUAD, in which one module (blue) was most related to tumorigenesis. Functional enrichment analyses showed that the genes in the blue module were mainly enriched in cell cycle, DNA transcription/replication and cancer pathways, etc. Combined with protein–protein interaction network, MTA1, PKMYT1 and FZR1 genes had the most intramodular connectivity, which were regarded as the hub genes. However, only FZR1 was validated to be overexpressed in lung tissues of COPD with LUAD and cigarette smoke extract-stimulated A549 cells, a human LUAD cell line. Conclusion This study suggests overexpression of FZR1 may play a key role in the tumorigenesis of LUAD in patients with COPD.

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“…In contrast, in a sample of 72 consecutive LC cases sourced from the Navarre University LC screening programme (Spain) with 3,477 participants, González et al (39) detected that risk of LC was associated with presence of airflow obstruction (OR =2.8; 95% CI, 1.6-5.2) and centrilobular emphysema (OR =34.3; 95% CI, 25.5-99.3), and that this risk decreased when associated with paraseptal emphysema (OR =4; 95% CI, 3.6-34.9). In a case-control study comprising 2,283 LC cases and 2,323 controls, with detection of COPD in 32.8% of patients in the LC group, Wang et al (40) found an association between risk and diagnosis of COPD (OR =2.88; 95% CI, 2.48-3.14), and in the case of the phenotype, between risk and presence of emphysema (OR =4.43; 95% CI, 2.85-6.88, P<0.001), after adjustment for smoking habit.…”

Section: Type Of Emphysema and Risk Of Lcmentioning

confidence: 99%

Lung emphysema and lung cancer: what do we know about it?

et al. 2020

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Emphysema and lung cancer (LC) are two diseases which share common risk factors, e.g., smoking. In recent years, many studies have sought to analyse this association. By way of illustration, we conducted a review of the scientific literature of the studies published to date, whose main designated aim was to demonstrate the relationship between emphysema and LC, and this association's influence on the histology, prognosis and molecular mechanisms responsible. We included over 40 studies (ranging from case-control and cohort studies to systematic reviews and meta-analyses), which highlight the association between emphysema and LC, independently of smoking habit. These studies also report a possible influence on histology, with adenocarcinoma being the most frequent lineage, and an association with poor prognosis, which affects both survival and post-operative complications. Oxidative stress, which generates chronic inflammatory status as well as the presence of certain polymorphisms in various genes (CYP1A1, TERT, CLPTM1L, ERK), gives rise-in the case of patients with emphysema-to alteration of cellular repair mechanisms, which in turn favours the proliferation of neoplastic epithelial cells responsible for the origin of LC.

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The link between chronic obstructive pulmonary disease phenotypes and histological subtypes of lung cancer: a case–control study

Cited by 26 publications

References 59 publications

The impact of emphysema on surgical outcomes of early-stage lung cancer: a retrospective study

The impact of emphysema on surgical outcomes of early-stage lung cancer: a retrospective study

Identification of Susceptible Genes for Chronic Obstructive Pulmonary Disease with Lung Adenocarcinoma by Weighted Gene Co-Expression Network Analysis

Lung emphysema and lung cancer: what do we know about it?

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