The Lipophilic Bullet Hits the Targets: Medicinal Chemistry of Adamantane Derivatives

Wanka, Lukas; Iqbal, Khalid; Schreiner, Peter R.

doi:10.1021/cr100264t

Cited by 579 publications

(499 citation statements)

References 837 publications

(1,592 reference statements)

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“…Among them, compound 3 exhibited moderate COX-2 inhibitory activity (Unsal- Tan et al 2012), with IC 50 values of 12.2 mM. In addition, compounds 3-7 were tested for their cytotoxic against the K562, A549, Huh-7, H1975, MCF-7, U937, BGC823, HL60, Hela and MOLT-4 cell lines using the CCK8 (DOjinDo, Kumamoto, Japan) method (Wanka et al 2013). However, none of the compounds exhibited cytotoxic effects on the tested cancer cell lines (IC 50 .…”

Section: Resultsmentioning

confidence: 99%

A new naphthalene glycoside from the sponge-derived fungus Arthrinium sp. ZSDS1-F3

Wang

et al. 2014

Natural Product Research

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(2014) A new naphthalene glycoside from the sponge-derived fungus Arthrinium sp. ZSDS1-F3, Natural Product Research: Formerly Natural Product Letters, 28:14, 1070-1074, DOI: 10.1080/14786419.2014 To link to this article: http://dx.doi.org/10.1080/14786419.2014.905935 PLEASE SCROLL DOWN FOR ARTICLETaylor & Francis makes every effort to ensure the accuracy of all the information (the "Content") contained in the publications on our platform. However, Taylor & Francis, our agents, and our licensors make no representations or warranties whatsoever as to the accuracy, completeness, or suitability for any purpose of the Content. Any opinions and views expressed in this publication are the opinions and views of the authors, and are not the views of or endorsed by Taylor & Francis. The accuracy of the Content should not be relied upon and should be independently verified with primary sources of information. Taylor and Francis shall not be liable for any losses, actions, claims, proceedings, demands, costs, expenses, damages, and other liabilities whatsoever or howsoever caused arising directly or indirectly in connection with, in relation to or arising out of the use of the Content.This One new naphthalene derivative, 1,8-dihydroxynaphthol-1-O-a-L-rhamnopyranoside (1), together with one known a-dibenzopyrone, alternariol (2), and five xanthones (3 -7) were isolated from the sponge-derived fungus Arthrinium sp. ZSDS1-F3. All the isolated compounds (1 -7) were established by comprehensive analysis of the spectral data, especially 1D and 2D NMR (HMQC and HMBC) spectra. In the primary bioassays, compound 3 exhibited moderate COX-2 inhibition, with IC 50 values of 12.2 mM.article may be used for research, teaching, and private study purposes. Any substantial or systematic reproduction, redistribution, reselling, loan, sub-licensing, systematic supply, or distribution in any form to anyone is

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Section: Resultsmentioning

confidence: 99%

A new naphthalene glycoside from the sponge-derived fungus Arthrinium sp. ZSDS1-F3

Wang

et al. 2014

Natural Product Research

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“…All of the isolated compounds were evaluated for their cytotoxic activities against the K562, MCF-7, HeLa, DU145, U937, H1975, SGC-7901, A549, MOLT-4, and HL60 cell lines using the CCK8 (Dojindo, Japan) method [14]. Among them, compounds 2 and 3 showed cytotoxicities against Hela, DU145, U937, and HL60 cell lines, with IC 50 values ranging from 3.8 to 41.1 PM.…”

Section: The Five Known Compounds Trans-(3r4s)-(-)-4-hydroxymelleinmentioning

confidence: 99%

One Strain-Many Compounds Method for Production of Polyketide Metabolites Using the Sponge-Derived Fungus Arthrinium arundinis ZSDS1-F3

Wang

et al. 2017

Chem Nat Compd

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“…Moreover, many of our derivatives bear an adamantyl substituent, and the antibacterial activity of a number of adamantane derivatives has been reported. [25][26][27][28][29] The in vitro antimicrobial testing was performed on five strains of microorganisms, Gram-positive Staphylococcus aureus and Bacillus subtilis, Gram-negative Escherichia coli and Klebsiella pneumoniae, and the fungus Candida albicans.…”

Section: Introductionmentioning

confidence: 99%

In vitro investigation of the antimicrobial activity of a series of lipophilic phenols and naphthols

Govender¹,

Govinden²,

Mocktar³

et al. 2016

S.Afr.j.chem.

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Five groups of phenols/naphthols (42 compounds in total) were synthesized and screened against Gram-positive Staphylococcus aureus and Bacillus subtilis, Gram-negative Escherichia coli and Klebsiella pneumoniae, and the fungus Candida albicans. Whereas compounds were found inactive against Gram-negative bacteria, potent activities against Gram-positive bacteria were observed. The activities correlate with the ability of molecules to form quinone methides, suggesting potential new modes of action.

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The Lipophilic Bullet Hits the Targets: Medicinal Chemistry of Adamantane Derivatives

Cited by 579 publications

References 837 publications

A new naphthalene glycoside from the sponge-derived fungus Arthrinium sp. ZSDS1-F3

A new naphthalene glycoside from the sponge-derived fungus Arthrinium sp. ZSDS1-F3

One Strain-Many Compounds Method for Production of Polyketide Metabolites Using the Sponge-Derived Fungus Arthrinium arundinis ZSDS1-F3

In vitro investigation of the antimicrobial activity of a series of lipophilic phenols and naphthols

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