The liquid-liquid extractive fermentation of L–lactic acid in a novel semi-partition bioreactor (SPB)

Teke, George M.; Gakingo, Godfrey Kabungo; Pott, Robert William McClelland

doi:10.1016/j.jbiotec.2022.10.017

Cited by 11 publications

(4 citation statements)

References 30 publications

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“…A lactic acid fermentation was demonstrated with the SPB, which improved the yield from 0.15 g L −1 h −1 to 0.35 g L −1 h −1 . 14 A computational fluid dynamics (CFD) simulation showed that a minimum agitation speed exists (Fig. 3D).…”

Section: Liquid–liquid Extraction For Bioprocess Intensificationmentioning

confidence: 97%

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Advances in in situ and in-line liquid–liquid extraction for bioprocess intensification

Chaichol

Weeranoppanant

2023

React. Chem. Eng.

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Section: Liquid–liquid Extraction For Bioprocess Intensificationmentioning

confidence: 97%

“…A number of separation techniques for bioprocesses include pervaporation, 2,3 distillation, 4,5 adsorption, 6,7 filtration, 8,9 electrodialysis, 10,11 and liquid–liquid extraction. 12–14 Methods are selected based on the compound differences in physical ( e.g. , size/molecular weight, volatility, solubility) and chemical ( e.g.…”

Section: Introductionmentioning

confidence: 99%

Advances in in situ and in-line liquid–liquid extraction for bioprocess intensification

Chaichol

Weeranoppanant

2023

React. Chem. Eng.

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“…The possibility to apply an in-situ extraction of lactic acid to the fermentation is part of current research and shows potential using different organic solvents. Teke et al use a mixture of tributyl phosphate, tri-n-octylamine and oleyl alcohol as extractant, while Gao et al use tri-n-decylamine and oleyl alcohol [ 22 , 71 ]. Both authors found an increase in the total lactic acid concentration of 62% and 68% and an increase in yield of 36% and 27%, respectively, with the in-situ extraction alcohol.…”

Section: Potential Future Applications For Simultaneous Fermentation ...mentioning

confidence: 99%

Simultaneous fermentation and enzymatic biocatalysis—a useful process option?

Oehlenschläger,

Schepp,

Stiefelmaier

et al. 2024

Biotechnol Biofuels

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Biotransformation with enzymes and de novo syntheses with whole-cell biocatalysts each have specific advantages. These can be combined to achieve processes with optimal performance. A recent approach is to perform bioconversion processes and enzymatic catalysis simultaneously in one-pot. This is a well-established process in the biorefinery, where starchy or cellulosic material is degraded enzymatically and simultaneously used as substrate for microbial cultivations. This procedure leads to a number of advantages like saving in time but also in the needed equipment (e.g., reaction vessels). In addition, the inhibition or side-reaction of high sugar concentrations can be overcome by combining the processes. These benefits of coupling microbial conversion and enzymatic biotransformation can also be transferred to other processes for example in the sector of biofuel production or in the food industry. However, finding a compromise between the different requirements of the two processes is challenging in some cases. This article summarises the latest developments and process variations. Graphical Abstract

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“…Unlike the current approaches, an integrated fermentation methods could be vital for MEL separation and purification especially in cases where pretreatment of lignocellulosic biomass releases byproduct that inhibits microbial growth and limits productivity (Faria, Santos, Ferreira, Marques, et al, 2014;Santos et al, 2019;Zhang et al, 2015). Teke et al (2022a) highlighted the efficacy of solvent extraction (using experimental and computational modeling) with a semi-partitioning bioreactor (SPB) configuration that merges fermentation and separation within one unit (Teke et al, 2022a(Teke et al, , 2022bTeke et al, 2023;Teke & Pott, 2021). This departure from the conventional setup incorporates solvent extraction within the SPB offering a novel approach with potential application in MEL production, streamlining the recovery process while enhancing yield and recovery.…”

Section: Solvent Extractionmentioning

confidence: 99%

A review on the upstream production and downstream purification of mannosylerythritol lipids

Valkenburg,

Ncube,

Teke

et al. 2023

Biotech & Bioengineering

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Biosurfactants are natural compounds with remarkable surface‐active properties that may offer an eco‐friendly alternative to conventional surfactants. Among them, mannosylerythritol lipids (MELs) stand out as an intriguing example of a glycolipid biosurfactant. MELs have been used in a variety of sectors for various applications, and are currently commercially produced. Industrially, they are used in the pharmaceutical, cosmetic, food, and agricultural industries, based on their ability to reduce surface tension and enhance emulsification. However, despite their utility, their production is comparatively limited industrially. From a bioprocessing standpoint, two areas of interest to improve the production process are upstream production and downstream (separation and purification) product recovery. The former has seen a significant amount of research, with researchers investigating several production factors: the microbial species or strain employed, the producing media composition, and the production strategy implemented. Improvement and optimization of these are key to scale‐up the production of MELs. On the other hand, the latter has seen comparatively limited work presented in the literature. For the most part traditional separation techniques have been employed. This systematic review presents the production and purification methodologies used by researchers by comprehensively analyzing the current state‐of‐the‐art with regards the production, separation, and purification of MELs. By doing so, the review presents different possible approaches, and highlights some potential areas for future work by identifying opportunities for the commercialization of MELs.

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The liquid-liquid extractive fermentation of L–lactic acid in a novel semi-partition bioreactor (SPB)

Cited by 11 publications

References 30 publications

Advances in in situ and in-line liquid–liquid extraction for bioprocess intensification

Advances in in situ and in-line liquid–liquid extraction for bioprocess intensification

Simultaneous fermentation and enzymatic biocatalysis—a useful process option?

A review on the upstream production and downstream purification of mannosylerythritol lipids

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