The liver in congestive heart failure

White, Thomas J.; Leevy, Carroll M.; Brusca, A; Gnassi, Angelo M.

doi:10.1016/0002-8703(55)90197-6

Cited by 46 publications

(19 citation statements)

References 19 publications

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It is well recognized that some liver function tests are abnormal in heart failure (Jolliffe, 1930;Felder, Mund, and Parker, 1950;Sherlock, 1951;White et al, 1955;Cantarow and Trumper, 1962). Richman, Delman, and Grob (1961) described alterations in indices of liver function in congestive heart failure with particular reference to serum enzymes and drew attention to the increased frequency of abnormal patterns of the tests in episodes of acute heart failure as against chronic heart failure.

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mentioning

confidence: 99%

Liver function in pulmonary heart disease.

Thomas¹,

Rees²,

Saunders³

1965

Heart

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It is well recognized that some liver function tests are abnormal in heart failure (Jolliffe, 1930;Felder, Mund, and Parker, 1950;Sherlock, 1951;White et al., 1955;Cantarow and Trumper, 1962). Richman, Delman, and Grob (1961) described alterations in indices of liver function in congestive heart failure with particular reference to serum enzymes and drew attention to the increased frequency of abnormal patterns of the tests in episodes of acute heart failure as against chronic heart failure. They and others have found the alkaline phosphatase, thymol turbidity, thymol flocculation, serum proteins, bilirubin, and cholesterol levels relatively insensitive in chronic heart failure (Felder et al., 1950). Richman et al. found the SGOT increased in 33 per cent of patients with increases limited almost entirely to those with acute failure. El-Shaboury, Thomas, and Williams (1964) found increases in SGOT levels in many patients with acute exacerbation of asthma, but without evidence of heart failure. Refsum (1963) showed a close correlation between SGOT and SGPT levels and severity of arterial hypoxaemia in severe pulmonary insufficiency. He remarked on the lack of correlation between the enzymatic changes and clinical signs of right heart failure.In most work the bromsulphthalein (BSP) retention was the most sensitive index of hepatic disorder in heart failure (Sherlock, 1951;Richman et al., 1961;Cantarow and Trumper, 1962).Maclagan and Rundle (1940) described the place of the galactose tolerance test in thyrotoxicosis and suggested that when the galactose index was high structural liver damage was present. It has been suggested that more rapid and complete intestinal absorption of galactose may play a part in this test in thyrotoxicosis, but apart from this, the galactose tolerance test is a test of structural liver damage (Cantarow and Trumper, 1962). The galactose may be given orally or intravenously and the measurements made either in the blood over a period of time up to two hours or in urine collected for five hours. Long experience of the oral galactose test with estimations made on blood samples as described by Maclagan and Rundle (1940) has satisfied us of its reliability and value. The present investigation was undertaken because of the observation that necropsy of the liver in many cases of pulmonary heart disease showed chronic passive venous congestion when right heart failure had not been noted during life. The galactose tolerance test was particularly studied but other indices of liver function were also recorded. METHOD AND SUBJECTSAt 9 a.m., after an overnight fast, 40 g. of galactose in solution was given orally. The blood sugar was estimated on blood taken just before the galactose was given and at half-hourly intervals for 2 hours afterwards. The majority of blood samples were taken by finger-prick method, but specimens for duplicate testing and comparison of methods were venous blood samples preserved with fluoride-oxalate.The blood sugar was estimated using the Haslewood and Strookman method wh...

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confidence: 99%

Liver function in pulmonary heart disease.

Thomas¹,

Rees²,

Saunders³

1965

Heart

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“…This relationship, noted also by other au thors (20,23,28) is easy to explain; it particularly concerns fi brosis which appears only in patients in whom failure repeatedlyoccurred for periods of over a yrear. An exception to this rule was found in only one of our patients who, however, had recurrently suffered from malaria for many years; chronic liver damage was therefore probably present even before the development of heart failure.…”

Section: B Anatomical Aspects Of Passive Hyperemia Of the Livermentioning

confidence: 58%

The Liver in Heart Failure : A Functional and Bioptical Study

Masini¹,

Scarlini²,

Concina³

et al. 1959

Cardiology

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“…Classically, there is a disproportionate elevation in the prothrombin time when compared with the serum bilirubin, which rarely exceeds 3 mg/dL in cases of congestive hepatopathy. 6 Serum albumin is typically normal unless frank cirrhosis has developed. Ascitic fluid analysis reveals an elevated serum albuminascites gradient (Z1.1 g/dL) typical of portal hypertension and demonstrates an elevated total protein level (Z2.5 g/dL) in the absence of significant liver fibrosis.…”

Section: Discussionmentioning

confidence: 99%

Liver Disease From Asymptomatic Constrictive Pericarditis

Sheth

Lim

2008

Journal of Clinical Gastroenterology

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Congestive hepatopathy is a known complication of cardiac disease and is typically identified in the context of an established cardiac diagnosis and profound cardiopulmonary symptoms. We report the case of a 28-year-old man with liver disease secondary to asymptomatic constrictive pericarditis. This case highlights the need for gastroenterologists to consider occult cardiac disease as a cause of unexplained liver dysfunction.

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The liver in congestive heart failure

Cited by 46 publications

References 19 publications

Liver function in pulmonary heart disease.

Liver function in pulmonary heart disease.

The Liver in Heart Failure : A Functional and Bioptical Study

Liver Disease From Asymptomatic Constrictive Pericarditis

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