2020
DOI: 10.1016/j.omtn.2020.01.030
|View full text |Cite
|
Sign up to set email alerts
|

The lncRNA-GAS5/miR-221-3p/DKK2 Axis Modulates ABCB1-Mediated Adriamycin Resistance of Breast Cancer via the Wnt/β-Catenin Signaling Pathway

Abstract: Drug resistance, including adriamycin (ADR)-based therapeutic resistance, is a crucial cause of chemotherapy failure in breast cancer treatment. Acquired chemoresistance has been identified to be closely associated with the overexpression of P-glycoprotein (P-gp/ABCB1). Long non-coding RNA (lncRNA) growth arrest-specific 5 (GAS5) can be involved in carcinogenesis; however, its roles in ABCB1-mediated ADR resistance are poorly understood. In this study, we identified a panel of differentially expressed lncRNAs,… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
2

Citation Types

6
77
0

Year Published

2020
2020
2024
2024

Publication Types

Select...
4
4
1

Relationship

0
9

Authors

Journals

citations
Cited by 121 publications
(83 citation statements)
references
References 37 publications
6
77
0
Order By: Relevance
“…Wnt signaling pathway is an evolutionarily conserved signaling pathway that regulates cell growth, differentiation, apoptosis, and self-renewal. In the occurrence and development of many types of human cancers, Wnt signaling pathway is often abnormally activated and can cooperate with or antagonize other signaling pathways to regulate tumor proliferation [16]. The mark of Wnt signaling is accumulation of active β-catenin, which transfers in nucleus and acts as transcription factor to induce transcription of target genes involved in cell division [17].…”
Section: Discussionmentioning
confidence: 99%
“…Wnt signaling pathway is an evolutionarily conserved signaling pathway that regulates cell growth, differentiation, apoptosis, and self-renewal. In the occurrence and development of many types of human cancers, Wnt signaling pathway is often abnormally activated and can cooperate with or antagonize other signaling pathways to regulate tumor proliferation [16]. The mark of Wnt signaling is accumulation of active β-catenin, which transfers in nucleus and acts as transcription factor to induce transcription of target genes involved in cell division [17].…”
Section: Discussionmentioning
confidence: 99%
“…LncRNAs have been reported to play essential roles in drug resistance in multiple cancers, such as breast cancer (16), gastric cancer (17), and lung cancer (18). For example, lnc-ATB/miR-200c promoted resistance to trastuzumab and then induced an invasion-metastasis cascade in breast cancer via upregulating ZEB1 and ZNF-217 (19).…”
Section: Discussionmentioning
confidence: 99%
“…Among these ncRNAs, lncRNAs, as the promising molecular markers for forecasting drug resistance of breast cancer, are becoming new targets for treating breast cancer in the future. For example, LOC645166, lncRNA GAS5, and lncRNA H19 regulate adriamycin resistance in breast cancer cells [4,19,20], and lncRNA UCA1 and lncRNA NONHSAT141924 modulates paclitaxel resistance [21,22], while lncRNA HOTAIRM1 and BLACAT1 can induce tamoxifen resistance in ER + breast cancer cells [23,24]. However, all these lncRNAs were identi ed from breast cancer tissue or cell lines, which limits their utilities in the clinic as a dynamic monitoring biomarker.…”
Section: Discussionmentioning
confidence: 99%
“…As one type of ncRNA transcripts, long non-coding RNAs (lncRNA) have been reported to function in a wide variety of cellular processes including drug resistance [4]. For example, NONHSAT101069, which serve as a ceRNA (competing endogenous RNA), promotes the epirubicin resistance of breast cancer cells by sponging miR-129-5p [5].…”
Section: Introductionmentioning
confidence: 99%