The loading of C-type natriuretic peptides improved hemocompatibility and vascular regeneration of electrospun poly(ε-caprolactone) grafts

Li, Jing; Zhuo, Na; Zhang, Jingai; Sun, Qiqi; Si, Jianghua; Wang, Kai; Zhi, Dengke

doi:10.1016/j.actbio.2022.08.032

Cited by 12 publications

(2 citation statements)

References 52 publications

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“…5B ). 56 The VG showed great blood compatibility in a rabbit arterial venous (AV)-shunt model for 1.5 hours of the test. One month post-implantation in a rat abdominal aorta replacement model, compared to its counterpart without CNPs, the CNP loaded with VGs showed significantly more EC coverage, NO production, VEGF secretion, M2 type macrophage polarization, contractile SMC transition, and ECM deposition, along with a parallel yet also 100% patency rate.…”

Section: Application Of Nanomaterials In Sdvgsmentioning

confidence: 94%

Nanomaterials for small diameter vascular grafts: overview and outlook

Wang,

Weng

et al. 2023

Nanoscale Adv.

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Section: Application Of Nanomaterials In Sdvgsmentioning

confidence: 94%

Nanomaterials for small diameter vascular grafts: overview and outlook

Wang,

Weng

et al. 2023

Nanoscale Adv.

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“…PCL is a medical-grade material extensively employed in the field of medicine and biomedical engineering. , Its excellent biocompatibility, commendable mechanical properties, controllable biodegradability, and suturability render it a highly promising material for crafting artificial vascular grafts. − The degradation performance of polymers is one of the key factors determining their applicability in the field of biomedical applications. , The lifetime of the implantable devices was determined by the degradation behavior of the biomaterials. During the in vivo degradation of polymers, processes such as water uptake, thermolysis, oxidation, hydrolysis, and dissolution occur, resulting in alterations in material properties and prompting specific interactions with the host.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of Vascular Grafts Using Poly(ε-Caprolactone) and Collagen-Encapsuled ADSCs for Interposition Implantation of Abdominal Aorta in Rhesus Monkeys

Jiang,

Zuo,

Wang

et al. 2024

ACS Biomater. Sci. Eng.

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The production of small-diameter artificial vascular grafts continues to encounter numerous challenges, with concerns regarding the degradation rate and endothelialization being particularly critical. In this study, porous PCL scaffolds were prepared, and PCL vascular grafts were fabricated by 3D bioprinting of collagen materials containing adipose-derived mesenchymal stem cells (ADSCs) on the internal wall of the porous PCL scaffold. The PCL vascular grafts were then implanted in the abdominal aorta of Rhesus monkeys for up to 640 days to analyze the degradation of the scaffolds and regeneration of the aorta. Changes in surface morphology, mechanical properties, crystallization property, and molecular weight of porous PCL revealed a similar degradation process of PCL in PBS at pH 7.4 containing Thermomyces lanuginosus lipase and in situ in the abdominal aorta of rhesus monkeys. The contrast of in vitro and in vivo degradation provided valuable reference data for predicting in vivo degradation based on in vitro enzymatic degradation of PCL for further optimization of PCL vascular graft fabrication. Histological analysis through hematoxylin and eosin (HE) staining and fluorescence immunostaining demonstrated that the PCL vascular grafts successfully induced vascular regeneration in the abdominal aorta over the 640-day period. These findings provided valuable insights into the regeneration processes of the implanted vascular grafts. Overall, this study highlights the significant potential of PCL vascular grafts for the regeneration of small-diameter blood vessels.

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