The logic behind neural control of breathing pattern

Ben-Tal, Alona; Wang, Yunjiao; Leite, Maria C. A.

doi:10.1038/s41598-019-45011-7

Cited by 8 publications

(5 citation statements)

References 41 publications

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“…The breathing pattern depends on chemoreceptor activity 22 , 47 , 48 and HF patients show hyperactivation of both central and peripheral chemoreceptors 49 . This is exemplified by HF patients with severe disease in whom strong chemoreceptor activation (due to the disease severity and the marked sympathetic activation) is associated with periodic breathing 50 .…”

Section: Discussionmentioning

confidence: 99%

“…This, as previously observed, could be due to a reduced ability to modulate the autonomic drive to the blood vessels because of an increased sympathetic tone and because of a less compliant vascular system. The breathing pattern depends on chemoreceptor activity 22,47,48 and HF patients show hyperactivation of both central and peripheral chemoreceptors 49 . This is exemplified by HF patients with severe disease in whom strong chemoreceptor activation (due to the disease severity and the marked sympathetic activation) is associated with periodic breathing 50 .…”

Section: Baroreflex Functionmentioning

confidence: 99%

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Respiratory patterns and baroreflex function in heart failure

Radaelli

Mancia

Balestri

et al. 2023

Sci Rep

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Little is known on the effects of respiratory patterns on baroreflex function in heart failure (HF). Patients with HF (n = 30, age 61.6 ± 10 years, mean ± SD) and healthy controls (CNT, n = 10, age 58.9 ± 5.6 years) having their R–R interval (RRI, EKG), systolic arterial blood pressure (SBP, Finapres) and respiratory signal (RSP, Respitrace) monitored, were subjected to three recording sessions: free-breathing, fast- (≥ 12 bpm) and slow- (6 bpm) paced breathing. Baroreflex sensitivity (BRS) and power spectra of RRI, SBP, and RSP signals were calculated. During free-breathing, compared to CNT, HF patients showed a significantly greater modulation of respiratory volumes in the very-low-frequency (< 0.04 Hz) range and their BRS was not significantly different from that of CNT. During fast-paced breathing, when very-low-frequency modulations of respiration were reduced, BRS of HF patients was significantly lower than that of CNT and lower than during free breathing. During slow-paced breathing, BRS became again significantly higher than during fast breathing. In conclusion: (1) in free-breathing HF patients is present a greater modulation of respiratory volumes in the very-low-frequency range; (2) in HF patients modulation of respiration in the very-low and low frequency (around 0.1 Hz) ranges contributes to preserve baroreflex-mediated control of heart rate.

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Section: Discussionmentioning

confidence: 99%

Section: Baroreflex Functionmentioning

confidence: 99%

Respiratory patterns and baroreflex function in heart failure

Radaelli

Mancia

Balestri

et al. 2023

Sci Rep

View full text Add to dashboard Cite

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“…This finding could help in modelling the cardiorespiratory system, as the existing work (Ben‐Tal et al . 2012, 2014, 2019; Ben‐Tal & Tawhai, 2013; Molkov et al . 2014) assumed periodic breathing was maladaptive rather than beneficial.…”

Section: Discussionmentioning

confidence: 99%

Relationship between cardiorespiratory phase coherence during hypoxia and genetic polymorphism in humans

Lancaster

Debevec

Millet

et al. 2020

The Journal of Physiology

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High altitude-induced hypoxia in humans evokes a pattern of breathing known as periodic breathing (PB), in which the regular oscillations corresponding to rhythmic expiration and inspiration are modulated by slow periodic oscillations. r The phase coherence between instantaneous heart rate and respiration is shown to increase significantly at the frequency of periodic breathing during acute and sustained normobaric and hypobaric hypoxia. r It is also shown that polymorphism in specific genes, NOTCH4 and CAT, is significantly correlated with this coherence, and thus with the incidence of PB. r Differences in phase shifts between blood flow signals and respiratory and PB oscillations clearly demonstrate contrasting origins of the mechanisms underlying normal respiration and PB. r These novel findings provide a better understanding of both the genetic and the physiological mechanisms responsible for respiratory control during hypoxia at altitude, by linking genetic factors with cardiovascular dynamics, as evaluated by phase coherence.

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“…The control of breathing muscles depends on various structures of the nervous system. Recent research (Del Negro et al 2018;Ben-Tal et al 2019) suggests that breathing control is a complex and adaptive process, the neural substrates of which are still not fully understood. The Breathing Central Pattern Generator (CPG) is located in the brain stem, but it has numerous connections with different cortical and subcortical areas of the brain.…”

Section: The Respiratory Apparatus: Muscles and Neural Controlmentioning

confidence: 99%

The Respiratory Foundations of Spoken Language

Fuchs

Rochet-Capellan

2021

Annu. Rev. Linguist.

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Why is breathing relevant in linguistics? In this review, we approach this question from different perspectives. The most popular view is that breathing adapts to speech because respiratory behavior has astonishing flexibility. We review research that shows that breathing pauses occur mostly at meaningful places, that breathing adapts to cognitive load during speech perception, and that breathing adapts to communicative needs in dialogue. However, speech may also adapt to breathing (e.g., the larynx can compensate for air loss, breathing can partially affect f0 declination). Enhanced breathing control may have played a role in vocalization and language evolution. These views are not mutually exclusive but, rather, reveal that speech production and breathing have an interwoven relationship that depends on communicative and physical constraints. We suggest that breathing should become an important topic for different linguistic areas and that future work should investigate the interaction between breathing and speech in different situational contexts. Expected final online publication date for the Annual Review of Linguistics, Volume 7 is January 14, 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

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The logic behind neural control of breathing pattern

Cited by 8 publications

References 41 publications

Respiratory patterns and baroreflex function in heart failure

Respiratory patterns and baroreflex function in heart failure

Relationship between cardiorespiratory phase coherence during hypoxia and genetic polymorphism in humans

The Respiratory Foundations of Spoken Language

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