The long noncoding RNA, TINCR, functions as a competing endogenous RNA to regulate PDK1 expression by sponging miR-375 in gastric cancer

Chen, Zhaoliang; Liu, Hong; Yang, Hui‐Li; Gao, Yukai; Zhang, Gongwen; Hu, Jiaojiao

doi:10.2147/ott.s137726

Cited by 55 publications

(48 citation statements)

References 21 publications

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“…It has been reported that H19 is upregulated in tumors including colorectal cancer, breast cancer, and bladder cancer (Raveh, Matouk, Gilon, & Hochberg, ). For instance, overexpression of H19 indicates unfavorable prognosis in colorectal cancer patients and can increase colon cancer cell proliferation (Chen, Liu, et al, ). H19‐derived miR‐675 can promote breast cancer progression via inhibiting c‐Cbl and Cbl‐b (Vennin et al, ).…”

Section: Discussionmentioning

confidence: 99%

H19 promotes non‐small‐cell lung cancer (NSCLC) development through STAT3 signaling via sponging miR‐17

Huang

Lei

et al. 2018

Journal Cellular Physiology

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LncRNAs can exhibit crucial roles in the development of multiple cancers, including non-small cell lung cancer (NSCLC). Currently, we investigated the role of lncRNA H19 in NSCLC. In our study, it was found that H19 was upregulated in A549 and H1299 cells compared to normal lung epithelial BEAS-2B cells. Meanwhile, we observed that miR-17 was downregulated in NSCLC cell lines. Inhibited H19 can suppress the growth, migration, and invasion of NSCLC cells and bioinformatics search was performed to predict the correlation between H19 and miR-17. Overexpression of miR-17 was able to inhibit the progression of NSCLC cells while reversely miR-17 inhibitors reversed this process. In addition, signal transducers and activators of transcription (STAT3), as an mRNA target of miR-17, was presented in our research. Moreover, we discovered that H19 demonstrated its biological functions via regulating miR-17 and STAT3 in vitro. Silencing H19 greatly increased STAT3 expression by sponging miR-19 in vitro. It was hypothesized that H19 may serve as a competing endogenous RNA (ceRNA) to modulate STAT3 by attaching miR-17 in lung cancer. In summary, our findings indicated that H19/miR-17/STAT3 axis participated in NSCLC development. H19 could be regarded as a significant prognostic biomarker in NSCLC progression.

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Section: Discussionmentioning

confidence: 99%

H19 promotes non‐small‐cell lung cancer (NSCLC) development through STAT3 signaling via sponging miR‐17

Huang

Lei

et al. 2018

Journal Cellular Physiology

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“…A novel regulatory circuitry has been recently identified that lncRNAs could function as a "sponge" to crosstalk with miRNAs (35). For example, lncRNA TINCR functions as a ceRNA to regulate PDK1 expression by sponging miR-375 in GC, in which tumor growth and invasion were suppressed with downregulated lncRNA TINCR and PDK1 (36). In the sepsis-induced acute kidney injury patients, the repression of lncRNA NEAT1 retarded the lipopolysaccharide-induced injury via overexpression of miR-204, as a result of inactivation of the NF-κB pathway, a potential pro-inflammatory pathway (37).…”

Section: Discussionmentioning

confidence: 99%

Silence of long noncoding RNA NEAT1 exerts suppressive effects on immunity during sepsis by promoting microRNA‐125‐dependent MCEMP1 downregulation

2019

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Accumulating studies have recognized microRNAs (miRs) and long noncoding RNAs (lncRNAs) as important molecules involved in the mediation of various biological processes, including innate immunity. In this study, we investigated a novel noncoding RNA regulatory circuitry in the immunity during sepsis. A cecal ligation and puncture‐induced sepsis mouse model was established to determine the expression of mast cell expression membrane protein 1 (MCEMP1). The RNA crosstalk among lncRNA nuclear enriched abundant transcript 1 (NEAT1), miR‐125, and MCEMP1 was validated. Subsequently, the levels of lncRNA NEAT1, miR‐125, and MCEMP1 in T lymphocytes isolated from sepsis mice were up‐ or downregulated by exogenous transfection in an attempt to investigate their effects on the release of inflammatory factors, the expression of immunoglobulins, the activity of T cell subsets and natural killer (NK) cells, as well as T lymphocyte apoptosis. In sepsis mice, MCEMP1 was highly expressed and verified to be a target gene of miR‐125. RNA crosstalk experiment revealed that lncRNA NEAT1 directly inhibited miR‐125 to upregulate MCEMP1. We also observed that elevation of miR‐125, depletion of MCEMP1, or downregulation of lncRNA NEAT1 resulted in promoted T lymphocyte activity, immunoglobulin expression, and NK cell activity, and inhibited release of inflammatory factors and T lymphocyte apoptosis. Taken together, these findings provided evidence that the downregulation of lncRNA NEAT1 could promote miR‐125 to exert an inhibitory effect on the immunity in septic mice by suppressing MCEMP1, highlighting a potential target for the treatment of sepsis. © 2019 IUBMB Life, 2019

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“…LncRNAs are extensively targeted by miRNAs through 3′ UTR or 5′UTR, meaning that they could serve as ceRNAs, the lncRNA as ceRNA were associated with cellular biological process and also serve important roles in tumorigenesis . Recent published studies confirmed the ceRNA theory involved in the progression of various types of cancer . These studies aimed at some genes including mRNA, miRNA, and lncRNA associated with the cancer and confirmed that some of genes serve important roles in treatment and prognosis.…”

Section: Introductionmentioning

confidence: 89%

“…11 Recent published studies confirmed the ceRNA theory involved in the progression of various types of cancer. [12][13][14][15] These studies aimed at some genes including mRNA, miRNA, and lncRNA associated with the cancer and confirmed that some of genes serve important roles in treatment and prognosis. With the development of experimental studies and techniques for lncRNA discovery, lncRNA-associated ceRNA networks have been constructed and analyzed in colorectal cancer, gastric cancer, and osteosarcoma.…”

Section: Introductionmentioning

confidence: 98%

Comprehensive analysis of five long noncoding RNAs expression as competing endogenous RNAs in regulating hepatoma carcinoma

Lou

Dong

et al. 2019

Cancer Medicine

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Liver cancer is the most common cancer and is the epitome of a recalcitrant cancer. Increasing evidence shown that long noncoding RNAs (lncRNA) were associated with cancer‐related death and could function as a competing endogenous RNA (ceRNA). To explore regulatory roles and potential prognostic biomarkers of lncRNA for liver cancer, RNA‐sequencing expression data were downloaded from the TCGA database and GEO database. A total of 357 patients were randomly divided into a discovery group and a validation group, of which 313 patients can obtain clinical data. In discovery phrase, 58 lncRNAs, 16 miRNAs, and 34 mRNAs were screened to construct the ceRNA network based on 252 patients employed from discovery group. Univariate and multivariate Cox hazard regression analysis model revealed that five lncRNAs (AATK‐AS1, C10orf91, LINC00162, LINC00200, and LINC00501) from 58 lncRNAs were formulated to predict the overall survival (OS). We used the value of gene expression and regression coefficients to construct a risk score based on the five lncRNAs. Next, we validated our model in the GSE116174 dataset (n = 64) and the validation group (n = 94) from TCGA database. Subgroup analysis suggest that the five lncRNAs played critical parts in early stage in cancer from both discovery and validation groups. The five lncRNAs were also found to be associated with immune cells infiltration including CD4+ memory activated, NK cells activated and mast cells activated, then the results were also validated according to the validation group. Furthermore, KEGG pathway enrichment analysis showed that these nine coexpressed modules using the method of WGCNA, and many of these pathways are associated with the development and progression of disease. At last, the transcription factor binding sites (TFBS) of the five lncRNAs were predicted, which help us to understand the potential mechanism that the TFBS adjusted the ceRNA network. In summary, the ceRNA regulatory network may contribute to a better understanding of liver cancer mechanism and provide potential prognostic biomarkers and therapeutic targets.

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The long noncoding RNA, TINCR, functions as a competing endogenous RNA to regulate PDK1 expression by sponging miR-375 in gastric cancer

Cited by 55 publications

References 21 publications

H19 promotes non‐small‐cell lung cancer (NSCLC) development through STAT3 signaling via sponging miR‐17

H19 promotes non‐small‐cell lung cancer (NSCLC) development through STAT3 signaling via sponging miR‐17

Silence of long noncoding RNA NEAT1 exerts suppressive effects on immunity during sepsis by promoting microRNA‐125‐dependent MCEMP1 downregulation

Comprehensive analysis of five long noncoding RNAs expression as competing endogenous RNAs in regulating hepatoma carcinoma

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