The long-term course of temporal lobe epilepsy: From unilateral to bilateral interictal epileptiform discharges in repeated video-EEG monitorings

Gollwitzer, Stephanie; Scott, Catherine; Farrell, Fiona; Bell, Gail S.; Tisi, Jane de; Walker, Matthew C.; Wehner, Tim; Sander, Josemir W.; Hamer, Hajo M.; Diehl, Beate

doi:10.1016/j.yebeh.2016.12.027

Cited by 22 publications

(17 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Hypothetically, bilateral epileptiform activity may be due to secondary epileptogenesis with broadening of the epileptogenic network [30,31], associated with longer seizure duration and especially higher seizure frequency as seen in animal models [32]. Conversely, we did not find any effect of epilepsy duration and seizure frequency on the distribution of either ictal seizure patterns or on interictal epileptiform activity, in line with others [33,34]. Yet, we found preoperative secondary generalized seizures to be associated with the occurrence of bilateral ictal and interictal epileptiform activity, presumably reflecting preexisting widespread network of epileptic pathologic circuits [34].…”

Section: Discussionsupporting

confidence: 88%

“…Conversely, we did not find any effect of epilepsy duration and seizure frequency on the distribution of either ictal seizure patterns or on interictal epileptiform activity, in line with others [33,34]. Yet, we found preoperative secondary generalized seizures to be associated with the occurrence of bilateral ictal and interictal epileptiform activity, presumably reflecting preexisting widespread network of epileptic pathologic circuits [34]. A further reason for the development of bilateral epileptiform discharges might be the epileptic spread initiating secondary seizure foci [35].…”

Section: Discussionsupporting

confidence: 76%

See 1 more Smart Citation

The role of presurgical EEG parameters and of reoperation for seizure outcome in temporal lobe epilepsy

Schmeiser

Zentner

Steinhoff

et al. 2017

Seizure

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 76%

The role of presurgical EEG parameters and of reoperation for seizure outcome in temporal lobe epilepsy

Schmeiser

Zentner

Steinhoff

et al. 2017

Seizure

View full text Add to dashboard Cite

show abstract

“…However, the accumulated evidence suggests that early surgical therapy is recommended for patients with DRE, especially with structural epilepsy such as MTLE with hippocampal sclerosis, cavernous malformations, or a benign tumor (44,(48)(49)(50). Furthermore, long-term unilateral TLE reportedly induces bilateral epileptogenicity (secondary epileptogenesis) and an unfavorable postsurgical outcome (51). Therefore, if we could have performed epilepsy surgery on the present case at a much earlier stage, for example, before the age of 10 years when the cat exhibited the minor seizure type, it might have been possible to inhibit secondary epileptogenicity and provide a better postoperative seizure outcome.…”

Section: Discussionmentioning

confidence: 99%

Focal Cortical Resection and Hippocampectomy in a Cat With Drug-Resistant Structural Epilepsy

et al. 2021

View full text Add to dashboard Cite

Epilepsy surgery is a common therapeutic option in humans with drug-resistant epilepsy. However, there are few reports of intracranial epilepsy surgery for naturally occurring epilepsy in veterinary medicine. A 12-year-old neutered female domestic shorthair cat with presumed congenital cortical abnormalities (atrophy) in the right temporo-occipital cortex and hippocampus had been affected with epilepsy from 3 months of age. In addition to recurrent epileptic seizures, the cat exhibited cognitive dysfunction, bilateral blindness, and right forebrain signs. Seizures had been partially controlled (approximately 0.3–0.7 seizures per month) by phenobarbital, zonisamide, diazepam, and gabapentin until 10 years of age; however, they gradually became uncontrollable (approximately 2–3 seizures per month). In order to plan epilepsy surgery, presurgical evaluations including advanced structural magnetic resonance imaging and long-term intracranial video-electroencephalography monitoring were conducted to identify the epileptogenic zone. The epileptogenic zone was suspected in the right atrophied temporo-occipital cortex and hippocampus. Two-step surgery was planned, and a focal cortical resection of that area was performed initially. After the first surgery, seizures were not observed for 2 months, but they then recurred. The second surgery was performed to remove the right atrophic hippocampus and extended area of the right cortex, which showed spikes on intraoperative electrocorticography. After the second operation, although epileptogenic spikes remained in the contralateral occipital lobe, which was suspected as the second epileptogenic focus, seizure frequency decreased to <0.3 seizure per month under treatment with antiseizure drugs at 1.5 years after surgery. There were no apparent complications associated with either operation, although the original neurological signs were unchanged. This is the first exploratory study of intracranial epilepsy surgery for naturally occurring epilepsy, with modern electroclinical and imaging evidence, in veterinary medicine. Along with the spread of advanced diagnostic modalities and neurosurgical devices in veterinary medicine, epilepsy surgery may be an alternative treatment option for drug-resistant epilepsy in cats.

show abstract

“…Some of these reports found that longer epilepsy duration (more than 20 years) was related to poorer outcomes after surgery while others found no relation between these parameters (37,(41)(42)(43). Although some authors suggested the possibility of secondary epileptogenesis in TLE (44)(45)(46), this hypothesis needs to be proved in future studies (47). Regarding the fact that both groups in our study had a longer epilepsy duration than 20 years, we consider that the effect of age does not play an important role in our results.…”

Section: Discussionmentioning

confidence: 99%

Positron Emission Tomography in Patients With Drug Resistant Temporal Lobe Epilepsy With Different Ictal Propagation Patterns in Scalp Eeg

Şırın¹,

Marangozoğlu²,

Gökyiğit³

et al. 2021

J Istanb Fac Med

View full text Add to dashboard Cite

Objective: In presurgical evaluation, positron emission tomography with fluorodeoxyglucose-F18 (FDG-PET) is an important tool in identifying epileptogenic area. The aim of this study was to evaluate glucose metabolism in FDG-PET in patients with temporal lobe epilepsy (TLE) showing 'switch-of lateralisation' (SL) and 'bilateral asynchrony' (BA) in ictal scalp EEG and compare their results with patients with TLE and none of these patterns.Methods: Twenty-four patients with TLE showing SL and/or BA in at least one of their seizures in video-EEG monitoring and 38 patients with TLE and without these patterns who had epilepsy surgery and a follow-up at least 5-years were included. The clinical, electrophysiological and imaging features were evaluated and a statistical comparison was performed between the groups.

show abstract

The long-term course of temporal lobe epilepsy: From unilateral to bilateral interictal epileptiform discharges in repeated video-EEG monitorings

Abstract: Introduction: Bilateral interictal epileptiform discharges (IED) and ictal patterns are common

Cited by 22 publications

References 40 publications

The role of presurgical EEG parameters and of reoperation for seizure outcome in temporal lobe epilepsy

The role of presurgical EEG parameters and of reoperation for seizure outcome in temporal lobe epilepsy

Focal Cortical Resection and Hippocampectomy in a Cat With Drug-Resistant Structural Epilepsy

Positron Emission Tomography in Patients With Drug Resistant Temporal Lobe Epilepsy With Different Ictal Propagation Patterns in Scalp Eeg

Contact Info

Product

Resources

About