The long-term survival of cartilage homografts in man

Gibson, Thomas; Davis, William B.; Curran, R. C.

doi:10.1016/s0007-1226(58)80030-2

Cited by 69 publications

(25 citation statements)

References 7 publications

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“…The use of fresh osteochondral allografts is supported by experimental 3,4,[17][18][19] and clinical 5,8,9,20,21 evidence of the viability and function of cartilage after transplantation. A review of our first 100 cases showed that the best indication for this procedure was a post-traumatic unipolar defect consisting of bone and cartilage, 12 in patients not considered for osteotomy alone because of the size of the osseous defect (Figs 6 and 7).…”

Section: Discussionmentioning

confidence: 99%

Fresh Osteochondral Allografts for Post-Traumatic Osteochondral Defects of the Knee

Ghazavi¹,

Pritzker

Davis³

et al. 1997

The Journal of Bone and Joint Surgery. British volume

198

125

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We used fresh small-fragment osteochondral allografts to reconstruct post-traumatic osteochondral defects in 126 knees of 123 patients with a mean age of 35 years. At a mean follow-up of 7.5 years (2 to 20), 108 knees were rated as successful (85%) and 18 had failed (15%).The factors related to failure included age over 50 years (p = 0.008), bipolar defects (p < 0.05), malaligned knees with overstressing of the grafts, and workers' compensation cases (p < 0.04). Collapse of the graft by more than 3 mm and of the joint space of more than 50% were seen more frequently in radiographs of failed grafts.Our encouraging clinical results for fresh smallfragment osteochondral allografts show that they are indicated for unipolar post-traumatic osteochondral defects of the knee in young active patients.

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Section: Discussionmentioning

confidence: 99%

Fresh Osteochondral Allografts for Post-Traumatic Osteochondral Defects of the Knee

Ghazavi¹,

Pritzker

Davis³

et al. 1997

The Journal of Bone and Joint Surgery. British volume

198

125

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“…Clinical and experimental observations have established that transplants of allogeneic cartilage usually resist rejection (Craigmyle, 1958;Gibson et al, 1958;Loeb, 1926). This particular feature of cartilage has been explained by the sequestration of chondrocytes by the matrix (Bacsich and Wyburn, 1947;Heyner, 1969Heyner, , 1973 and thus prevention of their contact with immunocompetent cells of the host.…”

Section: Introductionmentioning

confidence: 99%

Immune response by host after allogeneic chondrocyte transplant to the cartilage

Moskalewski

Hyc

Osiecka-Iwan

2002

Microscopy Res & Technique

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Chondrocytes constitutively express class I and, in some species, class II major histocompatibility complex (MHC). It is also possible that they possess specific differentiation antigen(s). Furthermore, lymphocytic cells, corresponding to NK cells, display spontaneous cytotoxic activity against chondrocytes. Studies on articular cartilage repair by transplants of allogeneic chondrocytes were mainly done on non-inbred animals, such as rabbits and hens. Surprisingly, only in single instances these transplants were rejected. In inbred rats, allogeneic chondrocytes transplanted into full-thickness defects in articular cartilage immediately after isolation evoked systemic immunological reaction and produced cartilage was rejected. Combined immunosuppression with cyclosporin A and cladribine did not prevent rejection of such transplants. Mechanical separation of transplants from bone marrow prevented sensitization of recipients and rejection of the produced cartilage. Successful allogeneic chondrocyte transplants in rabbits and hens could be tentatively explained by a certain degree of inbreeding among experimental animals, by the use of chondrocytes cultivated before grafting in artificial scaffolds and thus protected by matrix produced in vitro, and also by creation of a temporary mechanical barrier between transplant and bone marrow by tissues damaged during preparation of the defect.

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“…Cartilage has been shown to be highly immune privileged due to it's denisty and lack of blood supply [191,192]. As the mucosa is major antigenic structures within the trachea, we did not believe this minimal residual DNA would negatively impact 38 implants.…”

Section: All Treatment Groups Effectively Decellularize Rat Tracheamentioning

confidence: 96%

Tracheal Tissue Engineering

Birla

2014

Introduction to Tissue Engineering

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The long-term survival of cartilage homografts in man

Cited by 69 publications

References 7 publications

Fresh Osteochondral Allografts for Post-Traumatic Osteochondral Defects of the Knee

Fresh Osteochondral Allografts for Post-Traumatic Osteochondral Defects of the Knee

Immune response by host after allogeneic chondrocyte transplant to the cartilage

Tracheal Tissue Engineering

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