The Longitudinal Associations of Handgrip Strength and Cognitive Function in Aging Americans

McGrath, Ryan; Vincent, Brenda M.; Hackney, Kyle J.; Robinson‐Lane, Sheria G.; Downer, Brian; Clark, Brian C.

doi:10.1016/j.jamda.2019.08.032

Cited by 81 publications

(57 citation statements)

References 36 publications

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“…It seems that lower grip strength may cause cognitive decline and dementia, but it's still not enough to determine causality. Some suggested that cognitive function might precede muscle weakness (Jeong et al, 2018 ), others indicated that strength capacity and cognitive function might parallel each other (McGrath et al, 2020 ). However, based on the negative association between grip strength and the risk of cognitive impairment, it's significative for clinical work that taking grip strength as a tool to identify cognitive dysfunction early.…”

Section: Discussionmentioning

confidence: 99%

Grip Strength and the Risk of Cognitive Decline and Dementia: A Systematic Review and Meta-Analysis of Longitudinal Cohort Studies

Cui

Zhang

Liu

et al. 2021

Front. Aging Neurosci.

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Purpose: Loss of grip strength and cognitive impairment are prevalent in the elderly, and they may share the pathogenesis in common. Several original studies have investigated the association between them, but the results remained controversial. In this systematic review and meta-analysis, we aimed to quantitatively determine the relationship between baseline grip strength and the risk of cognitive impairment and provide evidence for clinical work.Methods: We performed a systematic review using PubMed, EMBASE, Cochrane, and Web of Science up to March 23, 2020, and focused on the association between baseline grip strength and onset of cognitive impairment. Next, we conducted a meta-analysis using a hazard ratio (HR) and 95% confidence interval (CI) as effect measures. Heterogeneity between the studies was examined using I2 and p-value. Sensitivity analyses and subgroup analyses were also performed, and publication bias was assessed by Begg's and Egger's tests.Results: Fifteen studies were included in this systematic review. After sensitivity analyses, poorer grip strength was associated with more risk of cognitive decline and dementia (HR = 1.99, 95%CI: 1.71–2.32; HR = 1.54, 95%CI: 1.32–1.79, respectively). Furthermore, subgroup analysis indicated that people with poorer strength had more risk of Alzheimer's disease (AD) and non-AD dementia (HR = 1.41, 95%CI: 1.09–1.81; HR = 1.45, 95%CI: 1.10–1.91, respectively).Conclusions: Lower grip strength is associated with more risk of onset of cognitive decline and dementia despite of subtype of dementia. We should be alert for the individuals with poor grip strength and identify cognitive dysfunction early.

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Section: Discussionmentioning

confidence: 99%

Grip Strength and the Risk of Cognitive Decline and Dementia: A Systematic Review and Meta-Analysis of Longitudinal Cohort Studies

Cui

Zhang

Liu

et al. 2021

Front. Aging Neurosci.

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“…For example, previous research has revealed that a temporal, bidirectional association exists for HGS and cognitive function. 94,95 Similarly, a longitudinal, bidirectional association may exist between HGS and metabolic diseases such as diabetes. 96,97 Such findings indicate that when paralleling associations exist, losses of function in one factor could lead to losses in the other.…”

Section: Discussionmentioning

confidence: 99%

What are the association patterns between handgrip strength and adverse health conditions? A topical review

et al. 2020

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Measures of handgrip strength can be used to conveniently assess overall muscle strength capacity. Although stand-alone measures of handgrip strength provide robust health information, the clinical meaningfulness to determine prevention and treatment options for weakness remains limited because the etiology of muscle weakness remains unclear. Moreover, clinical outcomes associated with handgrip strength are wide-ranging. Therefore, disentangling how handgrip strength is associated with health conditions that are metabolically or neurologically driven may improve our understanding of the factors linked to handgrip strength. The purpose of this topical review was to highlight and summarize evidence examining the associations of handgrip strength with certain health outcomes that are metabolically and neurologically driven. From this perusal of the literature, we posit that stand-alone handgrip strength be considered an umbrella assessment of the body systems that contribute to strength capacity, and a panoptic measurement of muscle strength that is representative of overall health status, not a specific health condition. Recommendations for future strength capacity–related research are also provided.

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“…Further analysis of the relationship between grip strength and overall cognition and various cognitive domains revealed that the grip strength correlated with overall cognition, time orientation, immediate recall, and language, but grip strength and orientation did not correlate with place, attention and calculation, and recall. Studies found 24 that every 5 kg higher handgrip strength was associated with lower odds (OR = 0.97, 95% CI = 0.93--0.99) for both future cognitive impairment and worse cognitive impairment. However, the relationship between grip strength and overall cognitive and its relationship with other cognitive domains need to be further observed.…”

Section: Relationship Between Grip Strength and MCImentioning

confidence: 99%

Relationship Between Physical Performance and Mild Cognitive Impairment in Chinese Community-Dwelling Older Adults

Liu¹,

Ma²,

Li³

et al. 2021

CIA

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This study aimed to examine the relationship between physical performance and mild cognitive impairment (MCI) in Chinese older adults. Methods: The sample comprised 956 relatively healthy and aged ≥65 years old Chinese community-dwelling participants (mean age, 72.56 ± 5.43 years; 56.8% female), which did not include those with dementia, severe cognitive impairment, mental illness etc. The Mini-Mental State Examination (MMSE) and the Instrumental Activities of Daily Living (IADL) scale were used for the initial classification of patients with MCI. Physical performance was measured via hand grip, Timed Up and Go Test (TUGT), and 4-m walking speed. Results: The physical performance (grip strength, TUGT, and 4-m walking speed) correlated with MCI. The grip strength [odds ratio (OR) = 0.96, 95% confidence interval (CI) = 0.93-0.99] and 4-m walking speed (OR = 0.25, 95% CI = 0.10-0.64) correlated negatively with MCI, while TUGT (OR = 1.08, 95% CI = 1.03-1.13) and MCI correlated positively. Conclusion: The physical performance (grip strength, TUGT, and 4-m walking speed) correlated with MCI. Further analysis showed that the grip strength was associated with overall cognition, time orientation, recall, and language, while TUGT and 4-m walking speed were associated with overall cognition and various cognitive domains, except recall.

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The Longitudinal Associations of Handgrip Strength and Cognitive Function in Aging Americans

Cited by 81 publications

References 36 publications

Grip Strength and the Risk of Cognitive Decline and Dementia: A Systematic Review and Meta-Analysis of Longitudinal Cohort Studies

Grip Strength and the Risk of Cognitive Decline and Dementia: A Systematic Review and Meta-Analysis of Longitudinal Cohort Studies

What are the association patterns between handgrip strength and adverse health conditions? A topical review

Relationship Between Physical Performance and Mild Cognitive Impairment in Chinese Community-Dwelling Older Adults

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