The loss rates for invasive prenatal testing in a specialised obstetric ultrasound practice

Scott, Fergus; Peters, Helen; Boogert, Tom; Robertson, R. G. H.; Anderson, John C.; McLennan, Andrew; Kesby, Greg; Edelman, David

doi:10.1111/j.0004-8666.2002.00061.x

Cited by 27 publications

(14 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our experience, a satisfactory sample of chorionic tissue was obtained in all 308 pregnancies with an overall success rate of 100%. A spontaneous abortion rate of 0.6% after the procedure was observed in this present study, which was quite low compared to other studies (10,11). This may be due to the small sample size in our series to show a real fetal loss rate.…”

contrasting

confidence: 84%

Early Prenatal Diagnosis of Thalassemia: The First Report of Experience in Mainland China

et al. 2011

View full text Add to dashboard Cite

In this study, we report our experience with chorionic villus sampling (CVS) for prenatal diagnosis of thalassemia in mainland China. During a 4-year period, 308 pregnant women chose to have CVS for prenatal diagnosis. Chorionic villus sampling was successful in all cases, and post-CVS abortion was seen in only two cases (0.6%). DNA diagnosis was correctly done in 307 (99.7%) prenatal samples but maternal contamination was found in one (0.3%) subject. In total, 77 pregnancies were found with an affected fetus, and all of the affected pregnancies were terminated within 1 week after the CVS procedure. Our experience indicates that CVS is a feasible and effective technique for prenatal diagnosis of thalassemia.

show abstract

contrasting

confidence: 84%

Early Prenatal Diagnosis of Thalassemia: The First Report of Experience in Mainland China

et al. 2011

View full text Add to dashboard Cite

show abstract

“…averages between 1 % and 2 % [1, 6,11,14,16,17] . According to these proportions and the specifi city of patients in our hospital, most of whom had elevated obstetrical risk, 3 -6 complications could be expected in a study of 316 amniocenteses.…”

Section: Discussionmentioning

confidence: 99%

Three years’ experience of using a 29-gauge atraumatic needle for amniocentesis

Tchirikov

Arnold²,

Oshovskyy³

et al. 2012

Journal of Perinatal Medicine

View full text Add to dashboard Cite

Aims: To quantify the procedure-related complication rate after using modifi ed technique of amniocentesis with a 29-gauge (29-G) pencil-point needle.Methods: This is a prospective, descriptive study of 316 amniocenteses that were performed by means of atraumatic 29-G pencil-point needle under ultrasound control. Results: A total of 316 amniocenteses were observed through the postprocedural period. The median time needed to retrieve 15 mL of amniotic fl uid was 4 min. A total of 19 pregnancies were terminated after genetic testing. No case was regarded as procedure-related fetal loss. No other complications were observed. Seventeen children were born before 37 completed weeks of gestation and fi ve children had a birth weight < 2000 g. Conclusions:Amniocentesis with the 29-G atraumatic pencil-point needle seems to be a safe procedure with extremely low risk of complications and is a good alternative to the traditional 22-G Quincke needle.

show abstract

“…These later studies suggest that advances in ultrasound, instrumentation and supervised training have considerably reduced the risk of CVS [7,8] . The determination of the fetal loss rate following CVS, however, varies between the different publications and there is a lack of concordance as to how it is determined and reported [9][10][11][12][13][14][15] . Some have defined a fetal loss as a pregnancy loss which occurs within 14 days of the procedure, whilst others have labelled a procedure loss as any loss at any gestation after the procedure irrespective of whether there may have been other attributable causes [9][10][11][12][13][14][15] .…”

mentioning

confidence: 99%

“…The determination of the fetal loss rate following CVS, however, varies between the different publications and there is a lack of concordance as to how it is determined and reported [9][10][11][12][13][14][15] . Some have defined a fetal loss as a pregnancy loss which occurs within 14 days of the procedure, whilst others have labelled a procedure loss as any loss at any gestation after the procedure irrespective of whether there may have been other attributable causes [9][10][11][12][13][14][15] . In addition, procedure loss has been reported as an absolute incidence or alternatively has been adjusted for the background spontaneous loss rate in women who did not undergo a CVS or amniocentesis [1,7,11] .…”

mentioning

confidence: 99%

Procedure-Related Fetal Loss following Chorionic Villus Sampling after First-Trimester Aneuploidy Screening

Wah

Leung²,

Cheng³

et al. 2016

Fetal Diagn Ther

View full text Add to dashboard Cite

Objective: The aim was to determine the institutional procedure-related fetal loss rate after chorionic villus sampling (CVS) and the factors which may identify pregnancies at increased risk of having a procedure-related loss. Materials and Methods: Pregnancy outcomes were retrieved of all women having a singleton pregnancy and undergoing a CVS procedure between 2004 and 2013 at a university hospital in Hong Kong. The incidence of procedure-related fetal loss due to unintended miscarriages adjusted for the background loss incidence of miscarriages was determined. Multivariate regression was performed to examine the factors contributing to an unintended fetal loss and miscarriage. Results: CVS was performed on 1,906 fetuses. The procedure-related fetal loss rate was 0.17% (95% CI -0.2 to 0.7). After multivariate analysis, a decreased plasma protein-A (PAPP-A) multiple of the median (OR 0.27; 95% CI 0.08-0.98, p = 0.046) was significantly associated with miscarriage in women who did not undergo a CVS. Patient-specific prediction of spontaneous abortion in women who did not undergo CVS was not statistically significant (AUC 0.56; 95% CI 0.49-0.6, p = 0.14). Conclusions: The CVS-related fetal loss rate adjusted for background loss was 0.17%. Pregnancies with reduced PAPP-A carry an increased risk of miscarriage irrespective of whether they had undergone an invasive procedure.

show abstract

The loss rates for invasive prenatal testing in a specialised obstetric ultrasound practice

Cited by 27 publications

References 7 publications

Early Prenatal Diagnosis of Thalassemia: The First Report of Experience in Mainland China

Early Prenatal Diagnosis of Thalassemia: The First Report of Experience in Mainland China

Three years’ experience of using a 29-gauge atraumatic needle for amniocentesis

Procedure-Related Fetal Loss following Chorionic Villus Sampling after First-Trimester Aneuploidy Screening

Contact Info

Product

Resources

About