The Lower Limit of Reference of Urinary Albumin/Creatinine Ratio and the Risk of Chronic Kidney Disease Progression in Patients With Type 2 Diabetes Mellitus

Tang, Wei‐Hua; Hung, Wei‐Chin; Wang, Chao-Ping; Wu, Cheng‐Ching; Hsuan, Chin-Feng; Yu, Teng‐Hung; Hsu, Chia‐Chang; Cheng, Ya-Ai; Chung, Fu‐Mei; Lee, Yau-Jiunn; Lu, Yung‐Chuan

doi:10.3389/fendo.2022.858267

Cited by 9 publications

(7 citation statements)

References 48 publications

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“…The result is consistent with the study by Chang et al (2019), which reported that every increase of 1 mg/dL of serum creatinine would significantly increase the risk of ESRD (HR 1.24,). Higher UACR was also associated with a significantly higher cumulative incidence of CKD progression in both male and female patients, as reported by Tang et al (2022). According to the 2012 KDIGO guideline, the prediction of CKD prognosis is based on the assessment of the eGFR and urinary albumin excretion (UAE) (Levin et al, 2013).…”

Section: Discussionmentioning

confidence: 93%

The role of plasma angiotensin-converting enzyme and interleukin-6 levels on the prognosis of non-dialysis chronic kidney disease patients

Susilo¹,

Thaha²,

Pikir³

et al. 2023

J Pharm Pharmacogn Res

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Context: Inflammatory factors and oxidative stress were discovered to play significant roles in the progression of chronic kidney disease (CKD). There is, however, no research on the direct impact of high plasma angiotensin converting enzyme (ACE) and interleukin (IL)-6 levels on CKD prognosis, particularly in non-hemodialysis patients. Aims: To investigate the potential role of plasma ACE and IL-6 levels in CKD prognosis. Methods: A total of 75 non-dialysis CKD patients participated in this cross-sectional study. The estimated glomerular filtration rate (e-GFR) and albuminuria were used to determine the prognosis of CKD. The plasma ACE and IL-6 levels were measured using an enzyme-linked immunoassay (ELISA). Spearman's rank correlational analysis was used to examine the relationship between ACE and IL-6 plasma levels with the prognosis of CKD. Results: The result showed a statistically significant correlation between age and plasma ACE (p = 0.038, r = 0.241), serum creatinine, and urine albumin-creatinine ratio with CKD prognosis (p<0.0001). A negative significant correlation was found between the e-GFR and CKD prognosis (p<0.0001). Additionally, there were also significant correlations between plasma ACE and IL-6 with CKD prognosis (p = 0.021, r = 0.266 and p = 0.04, r = 0.238, respectively). A significant positive correlation was also found between plasma ACE and IL-6 (p = 0.024, r = 0.260). Conclusions: There was a significant correlation between plasma ACE and IL-6 levels with CKD prognosis. Further investigation revealed a statistically significant positive relationship between plasma ACE and IL-6 levels.

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Section: Discussionmentioning

confidence: 93%

The role of plasma angiotensin-converting enzyme and interleukin-6 levels on the prognosis of non-dialysis chronic kidney disease patients

Susilo¹,

Thaha²,

Pikir³

et al. 2023

J Pharm Pharmacogn Res

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“…Data for 25,302 adults showed that a UACR cutoff of 16 mg/g may be more sensitive for identifying patients at high risk for cardiovascular mortality in the general population, compared to the traditional cutoff value (30 mg/g) 35 . However, Tang et.al demonstrated that UACR cutoff points of 8.44 mg/g overall, 10.59 mg/g in males, and 8.15 mg/g in females were associated with the risk of chronic kidney disease progression in patients with type 2 diabetes 36 . A meta‐analysis for general population cohorts found that increased relative risk for cardiovascular and all‐cause mortality and kidney outcomes at UACR of 10–29 mg/g is also apparent even when GFR is >60 mL/min/1.73 m 2 37 .…”

Section: Discussionmentioning

confidence: 99%

“… 35 However, Tang et.al demonstrated that UACR cutoff points of 8.44 mg/g overall, 10.59 mg/g in males, and 8.15 mg/g in females were associated with the risk of chronic kidney disease progression in patients with type 2 diabetes. 36 A meta‐analysis for general population cohorts found that increased relative risk for cardiovascular and all‐cause mortality and kidney outcomes at UACR of 10–29 mg/g is also apparent even when GFR is >60 mL/min/1.73 m 2 . 37 We indicated that participants with UACR over at least as low as 8.285 mg/g was significantly associated with the presence of vascular aging in our general rural participants with eGFR ≥60 mL/min/1.73 m 2 .…”

Section: Discussionmentioning

confidence: 99%

Association of high‐normal albuminuria and vascular aging: Hanzhong adolescent hypertension study

Du,

Wang,

et al. 2023

J of Clinical Hypertension

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Normoalbuminuria has recently been associated with increased cardiovascular risk, and vascular aging is proposed as the early manifestation of cardiovascular disease. Here, the authors aimed to examine the association of high‐normal albuminuria and vascular aging in a Chinese cohort. From our previously established cohort, 1942 participants with estimated glomerular filtration rate ≥60 mL/min/1.73 m2 or urinary albumin‐creatinine ratio (UACR) <30 mg/g were enrolled. Brachial‐ankle pulse wave velocity (baPWV) ≥1400 cm/s and/or carotid intima‐media thickness (CIMT) ≥0.9 mm were used as indicators of vascular aging. Multivariate regression and receiving operating characteristic curve analysis were performed to examine the relationship between continuous and categorical UACR with vascular aging. We found an average UACR value of 8.08 (5.45–12.52) mg/g in this study. BaPWV and CIMT demonstrated positive correlations with lg‐UACR (p < .05). High‐normal albuminuria (10–29 mg/g) was significantly associated with the presence of vascular aging after adjusting for multiple cardiovascular confounders (OR = 1.540, 95% CI = 1.203–1.972, p = .001). In addition, a lg‐UACR cutoff point of 0.918 lg(mg/g) (equal to UACR of 8.285 mg/g) was significantly associated with the presence of vascular aging and its components for all participants and those without hypertension or diabetes and without medication (p < .05). Briefly, high‐normal albuminuria was significantly associated with vascular aging in this sample of Chinese adults. These findings implied the warning of elevated UACR even within normal range in clinical practice and the importance of UACR screening in normoalbuminuria for early detection and prevention of cardiovascular disease in otherwise healthy participants.

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“…Blood samples were collected after fasting for a minimum of 8 hours. Serum uric acid and complete blood count were measured using standard methods with an automatic biochemical analysis system (Hitachi 7170A, Tokyo, Japan) as reported previously ( 23 ). In addition, serum creatinine was measured using the Jaffe method.…”

Section: Methodsmentioning

confidence: 99%

FABP3, FABP4, and heart rate variability among patients with chronic schizophrenia

Hung

et al. 2023

Front. Endocrinol.

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IntroductionThe prevalence of cardiovascular disease (CVD) and CVD-related deaths in patients with schizophrenia is high. An elevated risk of CVD has been associated with low heart rate variability (HRV). There is increasing evidence that fatty acid-binding protein (FABP)3 and FABP4 play roles in the development and progression of CVD. This study aimed to explore the association of circulating FABP3/FABP4 levels with HRV in patients with chronic schizophrenia.MethodsWe included 265 consecutive patients with chronic schizophrenia who attended a disease management program. We used an enzyme-linked immunosorbent assay for the measurement of plasma concentrations of FABP3 and FABP4. Standard HRV was recorded at baseline following a standard protocol. Mean high- and low-frequency (HF/LF) HRV values were analyzed by tertile of FABP3 and FABP4 using one-way analysis of variance, and linear regression analysis was performed to assess trends.ResultsA positive association between FABP3 and creatinine was found in multiple regression analysis. In addition, negative associations between levels of hematocrit, hemoglobin, HF HRV, and estimated glomerular filtration rate (eGFR) with FABP3 were also found. Moreover, positive associations between FABP4 with body mass index, diabetes mellitus, hypertension, systolic blood pressure, low-density lipoprotein-cholesterol, triglycerides, creatinine, and FABP3 were found. Furthermore, negative associations between levels of high-density lipoprotein-cholesterol, eGFR, and HF HRV with FABP4 were found. We also found a significant inverse association between FABP3 and HF HRV (p for trend = 0.008), and significant inverse associations between FABP4 with HF and LF HRV (p for trend = 0.007 and 0.017, respectively).DiscussionTogether, this suggests that elevated levels of FABP3 and FABP4 may be linked to health problems related to CVD in patients with chronic schizophrenia.

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The Lower Limit of Reference of Urinary Albumin/Creatinine Ratio and the Risk of Chronic Kidney Disease Progression in Patients With Type 2 Diabetes Mellitus

Cited by 9 publications

References 48 publications

The role of plasma angiotensin-converting enzyme and interleukin-6 levels on the prognosis of non-dialysis chronic kidney disease patients

The role of plasma angiotensin-converting enzyme and interleukin-6 levels on the prognosis of non-dialysis chronic kidney disease patients

Association of high‐normal albuminuria and vascular aging: Hanzhong adolescent hypertension study

FABP3, FABP4, and heart rate variability among patients with chronic schizophrenia

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