The lowering effect of Gum Arabic on hyperlipidemia in Sudanese patients

Mohamed, R.; Gadour, Mohammed O.; Adam, Ishag

doi:10.3389/fphys.2015.00160

Cited by 41 publications

(20 citation statements)

References 27 publications

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“…GA did not increase HDL level, which would be favorable for SCD patients. Our results are consistent with previous study conducted among Sudanese population; GA reduced LDL with no effect on HDL [30]. And other contradictory outcomes revealed the augmenting effect of GA on HDL among diabetic patients [31].…”

Section: Discussionsupporting

confidence: 92%

Acacia Senegal (Gum Arabic) Supplementation Modulate Lipid Profile and Ameliorated Dyslipidemia among Sickle Cell Anemia Patients

Kaddam

Fadl-Elmula

Eisawi³

et al. 2019

Journal of Lipids

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Background. Sickle cell disease (SCD) is an inherited haemolytic anemia with a variable course and severity. Knowledge of prognostic biomarkers may help in the establishment of therapeutic intervention, management, and follow-up of patients. There have been scattered reports of low high-density lipoprotein cholesterol (HDL-C) and increased triglyceride (TG) in SCD patients. In addition, TG levels have been suggested to be elevated in patients with increased endothelial activation. An increased TG level has been associated with haemolysis, vascular dysfunction, and increased prevalence of pulmonary hypertension. Gum Arabic (GA) is an edible, dried, gummy exudate from the acacia Senegal tree. Several studies on GA ingestion have shown reduced plasma cholesterol and low-density lipoprotein (LDL) concentrations in both animals and humans. We investigated GA’s therapeutic potential to modulate serum lipids in patients with sickle cell anemia. Methods. This study recruited and documented secondary outcomes in 47 patients (aged 5–42 years) carrying hemoglobin SS. The patients received 30 g/day of GA for 12 weeks. Total cholesterol, TG, LDL, and HDL were measured before and after GA intake. Cobas C311 (Roche, Germany) automated chemistry analyser was used for direct determination of the values of the lipid profile. Results. GA significantly decreased total cholesterol (TC), TG, and LDL (p = 0.006, 0.04, and 0.02, resp.). GA showed no effect on HDL level. Baseline serum TG and LDL correlated significantly with the hydrogen peroxide (H2O2) level, which is known as an oxidative stress marker (p = 0.003 and 0.04, resp.). None of the lipid profile elements correlated with age. Conclusion. Our results revealed that dyslipidemia in sickle cell patients is associated with oxidative stress but not associated with age. The findings showed that GA significantly decreased TC, LDL, and TG levels, revealing a novel effect of GA, which is considered a natural dietary fibre that can modulate lipid profile in patients with sickle cell anemia. Trial Registration. This retrospective trial is registered with ClinicalTrials.gov Identifier: NCT02467257 on 3 June, 2015.

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Section: Discussionsupporting

confidence: 92%

Acacia Senegal (Gum Arabic) Supplementation Modulate Lipid Profile and Ameliorated Dyslipidemia among Sickle Cell Anemia Patients

Kaddam

Fadl-Elmula

Eisawi³

et al. 2019

Journal of Lipids

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“…We also have observed that added AF caused foaming of the final product. This may be due to the fact that AF contains about 95% of soluble fibres (Mohamed et al , ). In each of the studied cases, the shear thinning was observed from 0 to 5 s. At intermediate shear rates from 5 to 15 s viscosity decreased and then became almost constant.…”

Section: Resultsmentioning

confidence: 99%

Effect of different fibres on texture, rheological and sensory properties of acid casein processed cheese sauces

Szafrańska

Sołowiej

2020

Int J of Food Sci Tech

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The objective of this study was the evaluation of different fibres (bamboo, acacia, potato or citrus) addition on texture, rheological and sensory properties of acid casein processed cheese sauces. Fibres used in production of sauces had an impact on the texture, viscosity, viscoelastic and sensory properties. The largest increase in viscosity was observed in products with addition of potato fibre, which have good water holding and adsorption capacity. Processed cheese sauce with the addition of citrus fibre was characterised by the highest values in general, and the increase of this feature in the tested samples was regular. Adhesiveness was the highest in products with 1% addition of every fibre. The lowest values of viscosity single shear, G 0 and G″ moduli, among all tested, had sauces with acacia fibre. Moreover, they had the most thin liquid consistency, which was different from preferred one.

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“…It is known from our previous in vitro studies that L. plantarum MBTU-HK1 has the ability to assimilate cholesterol from growth media (due to the production of the BSH enzyme), and thus the reduced level of cholesterol in the probiotic and synbiotic groups can be attributed to the bile salt hydrolase activity of the test strain. The results obtained in the in vitro study have thus been proven in the in vivo experiments in [25][26][27][28]. In all the treatment groups triglycerides were reduced and the synbiotic group possessed the lowest level of triglycerides, which is supported by the results of [29], which demonstrated that L. acidophilus and B. bifidum can significantly decrease the serum levels of LDL and triglycerides.…”

Section: Discussionmentioning

confidence: 55%

Role of L. plantarum KX519413 as Probiotic and Acacia Gum as Prebiotic in Gastrointestinal Tract Strengthening

et al. 2019

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Probiotics, prebiotics, and synbiotics are potential mediators to maintaining healthy intestinal flora and have garnered an area of wide research in the past few years. The current study assesses the in vivo effects of probiotic (Lactobacillus plantarum MBTU-HK1), prebiotic (acacia gum) (either singly or in combination as a synbiotic on growth performance), biochemical, hematological, physiological, and immunological effects and their role in the reduction of procarcinogen enzyme activities in male Balb/c mice. The absence of treatment-related toxicity and a normal physiological range of biochemical and hematological parameters ensure their safe consumption. The synbiotic group was found to possess lowered cholesterol levels and enhanced protein and mineral content. The probiotic and synbiotic groups reinforced immunoglobulin levels and had a modulatory effect on phagocytosis. A lymphocyte proliferation pattern suggested the stimulatory effect of synbiotic combination on splenocyte viability and proliferation. Total antioxidant capability in the liver was determined by a 2,2-diphenyl-1-picrylhydrazyl assay and all the treatment groups were found to possess increased scavenging activity. Synbiotic and prebiotic treatment was observed to lead to reduced tumor necrosis factor α (TNF-α) levels. Bacterial procarcinogenic fecal enzyme activities were found to be decreased, proving their role in the prevention of colon cancer incidence. This study proves the potency and safety of oral administration of L. plantarum MBTU-HK1 and acacia gum either individually or in combination.

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The lowering effect of Gum Arabic on hyperlipidemia in Sudanese patients

Cited by 41 publications

References 27 publications

Acacia Senegal (Gum Arabic) Supplementation Modulate Lipid Profile and Ameliorated Dyslipidemia among Sickle Cell Anemia Patients

Acacia Senegal (Gum Arabic) Supplementation Modulate Lipid Profile and Ameliorated Dyslipidemia among Sickle Cell Anemia Patients

Effect of different fibres on texture, rheological and sensory properties of acid casein processed cheese sauces

Role of L. plantarum KX519413 as Probiotic and Acacia Gum as Prebiotic in Gastrointestinal Tract Strengthening

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