This paper proposes a novel framework called ‘cultural affordances’ to examine the dynamic interplay among technology, users and culture, as multilevel and multidirectional interactive networks. The framework includes three dimensions. 1) Cultural affordances of technology describe what technology can offer users and culture in terms of behavioural or cultural changes. 2) Cultural affordances of users describe what users can offer other users, technology and culture in terms of behavioural, technological or cultural changes. 3) Affordances of the cultural describe what culture can offer users and technology in terms of the design and use of technology as well as related changes. To establish the need for a culturally oriented extension to affordance theory, we first revisit Gibson's original definition of affordances of the environment and discuss its significance and limitations, including the need to understand the interplay between technology and users in the digital era. We contend that culture, as an assemblage of all relations and practices, should be included as an indispensable part of affordance theory, and we provide a detailed explanation of the novel, three-dimensional framework of cultural affordances. We then apply the framework to three prior empirical studies and one ongoing study to demonstrate how the framework can be used as an analytic tool to deepen our understanding of the multilevel and multidirectional interplay among technology, users and culture, and we identify related changes, focusing on WeChat. We also discuss how the framework can provide directions for designing new technologies to improve collaborations among users, between users and designers, and between an online platform and the offline world.