The lure of novel biological and chemical entities in food-system transformations

Jørgensen, Peter Søgaard; Ortega, Daniel I. Avila; Blasiak, Robert; Cornell, Sarah; Gordon, Line; Nyström, Magnus; Olsson, Per Olof

doi:10.1016/j.oneear.2022.09.011

Cited by 2 publications

(4 citation statements)

References 13 publications

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“…Two well-described and related forms of reinforcing dynamics in the scaling phase are sequential resource exploitation and innovation arms races. Illustrative cases of the former are sequential marine resources harvesting after collapsing stocks [103,104] and the sequential exploitation of new agricultural inputs, such as fertilizers, pesticides and machinery, to reduce labour costs [1,19,102]. An example of arms races is weapons arms races that occur in response to increasing threats (real or perceived), a process underlying the trap of existential technology, such as nuclear weapons [37,45,49,102].…”

Section: A Model Of Trap Evolutionmentioning

confidence: 99%

“…After this initiation, growing rates of environmental and social change increase the need for adaptation through further innovation, and multi-level selection increases connectivity and the establishment of global systems [3,101]. An important dynamic in these two phases that contribute to the early build-up of traps is that sequential selection will often address short-term, local and monitored (known) consequences, but less so undesired longer-term, spatially displaced and unmonitored global outcomes [95,101,102]. Two well-described and related forms of reinforcing dynamics in the scaling phase are sequential resource exploitation and innovation arms races.…”

Section: (A) Initiation and Scalingmentioning

confidence: 99%

Section: (A) Initiation and Scalingmentioning

confidence: 99%

“…R. Soc. B 379: 20220261 threats (real or perceived), a process underlying the trap of existential technology, such as nuclear weapons [37,45,49,102].…”

Section: (A) Initiation and Scalingmentioning

confidence: 99%

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Evolution of the polycrisis: Anthropocene traps that challenge global sustainability

Søgaard Jørgensen,

Jansen,

Avila Ortega

et al. 2023

Phil. Trans. R. Soc. B

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The Anthropocene is characterized by accelerating change and global challenges of increasing complexity. Inspired by what some have called a polycrisis, we explore whether the human trajectory of increasing complexity and influence on the Earth system could become a form of trap for humanity. Based on an adaptation of the evolutionary traps concept to a global human context, we present results from a participatory mapping. We identify 14 traps and categorize them as either global, technology or structural traps. An assessment reveals that 12 traps (86%) could be in an advanced phase of trapping with high risk of hard-to-reverse lock-ins and growing risks of negative impacts on human well-being. Ten traps (71%) currently see growing trends in their indicators. Revealing the systemic nature of the polycrisis, we assess that Anthropocene traps often interact reinforcingly (45% of pairwise interactions), and rarely in a dampening fashion (3%). We end by discussing capacities that will be important for navigating these systemic challenges in pursuit of global sustainability. Doing so, we introduce evolvability as a unifying concept for such research between the sustainability and evolutionary sciences. This article is part of the theme issue ‘Evolution and sustainability: gathering the strands for an Anthropocene synthesis’.

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Section: A Model Of Trap Evolutionmentioning

confidence: 99%

Section: (A) Initiation and Scalingmentioning

confidence: 99%

Section: (A) Initiation and Scalingmentioning

confidence: 99%

“…R. Soc. B 379: 20220261 threats (real or perceived), a process underlying the trap of existential technology, such as nuclear weapons [37,45,49,102].…”

Section: (A) Initiation and Scalingmentioning

confidence: 99%

See 2 more Smart Citations

Evolution of the polycrisis: Anthropocene traps that challenge global sustainability

Søgaard Jørgensen,

Jansen,

Avila Ortega

et al. 2023

Phil. Trans. R. Soc. B

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Screening, identification, and antibiotic activity of secondary metabolites of Penicillium sp. LPB2019K3-2 isolated from endemic amphipods of Lake Baikal

et al. 2022

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This study aimed to assess the influence of nutrient media content on the production of antibiotics and the ability of water fungi isolated from lake Baikal to synthesize novel natural products. Interest in this topic stems from the high demand for new drugs, and studies are carried out via the screening of new natural products with biological activity produced by unstudied or extremophilic microorganisms. For this study, a strain of Penicillium sp. was isolated from endemic Baikal phytophagous amphipod species. Here, we identified natural products using the following classical assays: biotechnological cultivation, MALDI identification of the strain, natural product extraction, antimicrobial activity determination, and modern methods such as HPLC-MS for the dereplication and description of natural products. It was found that many detected metabolites were not included in the most extensive database. Most of the identified metabolites were characterized by their biological activity and demonstrated antibiotic activity against model Gram-positive and Gram-negative bacteria. The isolated strain of water fungus produced penicolinate B, meleagrin A, austinoneol A, andrastin A, and other natural products. Additionally, we show that the synthesis of low-molecular-weight natural products depends on the composition of the microbiological nutrient media used for cultivation. Thus, although the golden age of antibiotics ended many years ago and microscopic fungi are well studied producers of known antibiotics, the water fungi of the Lake Baikal ecosystem possess great potential in the search for new natural products for the development of new drugs. These natural products can become new pharmaceuticals and can be used in therapy to treat new diseases such as SARS, MERS, H5N1, etc.

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The lure of novel biological and chemical entities in food-system transformations

Cited by 2 publications

References 13 publications

Evolution of the polycrisis: Anthropocene traps that challenge global sustainability

Evolution of the polycrisis: Anthropocene traps that challenge global sustainability

Screening, identification, and antibiotic activity of secondary metabolites of Penicillium sp. LPB2019K3-2 isolated from endemic amphipods of Lake Baikal

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