2023
DOI: 10.3892/or.2023.8627
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The macrophage polarization by miRNAs and its potential role in the treatment of tumor and inflammation (Review)

Chaozhe Wang,
Xidi Wang,
Danfeng Zhang
et al.

Abstract: The characteristics of monocyte/macrophage lineage are diversity and plasticity, mainly manifested by M1 and M2 subtypes in the body tissues, and playing different roles in the immunity. In the polarization process of macrophages, the classic molecular mechanism is related to sequential transcription factors. Whether in tumor or inflammatory local microenvironment, the pathological factors of the local microenvironment often affect the polarization of M1 and M2 macrophages, and participate in the occurrence an… Show more

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Cited by 7 publications
(2 citation statements)
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References 207 publications
(253 reference statements)
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“…148,149 The delivery of cells or miRNAmediated macrophage polarization is also considered an important mediator. 150,151 For example, Zhang et al encapsulated gingiva-derived mesenchymal stem cells (GMSCs) in the methacrylate 3D-collagen hydrogel and cooperated with the decellularized small intestine submucosal extracellular matrix (SIS-ECM) to significantly accelerate functional recovery and axon regeneration in rat sciatic nerve injury, accompanied by an increased infiltration of M2 macrophages and decreased infiltration of M1 macrophages at injury site. 152 Likewise, poly(lactic-co-glycolic) acid (PLGA)/ECM conduits filled with epidermal neural crest stem cells (EPI-NCSCs) for repairing injured rat sciatic nerve also showed an increased expression of anti-inflammatory cytokines (IL-4, IL-13) and decreased expression levels of M1 macrophages (low expression of IL-6, TNF-a) 7 days post-injury.…”
Section: Biochemical Signals Materials and Resultsmentioning
confidence: 99%
“…148,149 The delivery of cells or miRNAmediated macrophage polarization is also considered an important mediator. 150,151 For example, Zhang et al encapsulated gingiva-derived mesenchymal stem cells (GMSCs) in the methacrylate 3D-collagen hydrogel and cooperated with the decellularized small intestine submucosal extracellular matrix (SIS-ECM) to significantly accelerate functional recovery and axon regeneration in rat sciatic nerve injury, accompanied by an increased infiltration of M2 macrophages and decreased infiltration of M1 macrophages at injury site. 152 Likewise, poly(lactic-co-glycolic) acid (PLGA)/ECM conduits filled with epidermal neural crest stem cells (EPI-NCSCs) for repairing injured rat sciatic nerve also showed an increased expression of anti-inflammatory cytokines (IL-4, IL-13) and decreased expression levels of M1 macrophages (low expression of IL-6, TNF-a) 7 days post-injury.…”
Section: Biochemical Signals Materials and Resultsmentioning
confidence: 99%
“…Moreover, overexpression of miR-19a/b was associated with the female gender, elderly patients, several mutations such as U2AF1, C-KIT, CEBPA, and IDH1/2, and a poor prognosis (lower CR rates and OS) [107]. MiR-19a inhibits the M1 subtype by targeting STAT1 and interferon regulatory factor 1 (IRF1) [108] and promotes the M2 macrophage phenotype by activating STAT3 [109].…”
Section: Micrornas Associated With a Bad Prognosis In Aml And M2 Pola...mentioning
confidence: 99%