2015
DOI: 10.1016/j.ceb.2015.08.002
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The MAGE protein family and cancer

Abstract: The Melanoma Antigen Gene (MAGE) protein family is a large, highly conserved group of proteins that share a common MAGE homology domain. Intriguingly, many MAGE proteins are restricted in expression to reproductive tissues, but are aberrantly expressed in a wide-variety of cancer types. Originally discovered as antigens on tumor cells and developed as cancer immunotherapy targets, recent literature suggests a more prominent role for MAGEs in driving tumorigenesis. This review will highlight recent developments… Show more

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Cited by 205 publications
(195 citation statements)
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“…The results suggest additional mechanisms involving MAGE-A11 and Skp2 contribute to prostate cancer growth and support previous evidence implicating MAGE family proteins in specifying novel substrates through direct binding or influencing the subcellular location of E3 ligases (Hao et al, 2013; Weon and Potts, 2015; Pineda et al, 2015). There is evidence that MAGE-G1 and MAGE-C2 regulate RING protein complexes of E3 ubiquitin ligases (Doyle et al, 2010).…”
Section: 0 Discussionsupporting
confidence: 88%
“…The results suggest additional mechanisms involving MAGE-A11 and Skp2 contribute to prostate cancer growth and support previous evidence implicating MAGE family proteins in specifying novel substrates through direct binding or influencing the subcellular location of E3 ligases (Hao et al, 2013; Weon and Potts, 2015; Pineda et al, 2015). There is evidence that MAGE-G1 and MAGE-C2 regulate RING protein complexes of E3 ubiquitin ligases (Doyle et al, 2010).…”
Section: 0 Discussionsupporting
confidence: 88%
“…In fact, when LAYN , MAGEH1 , and CCR8 (which represent three of the most enriched genes in tumor-infiltrating Treg cells) are highly detected in whole-tumor samples there is a significant worsening of the 5-year survival of both CRC and NSCLC patients. Although, the functional roles in Treg cells of LAYN, a transmembrane protein with homology to c-type lectin (Borowsky and Hynes, 1998), and of MAGEH1, a member of the melanoma antigen gene family (Weon and Potts, 2015), are unknown, the high expression of the chemokine receptor CCR8 is instead intriguing. Indeed, CCL18, the ligand of CCR8 (Islam et al., 2013), is highly expressed in different tumors including NSCLC (Chen et al., 2011, Schutyser et al., 2005).…”
Section: Discussionmentioning
confidence: 99%
“…Two-thirds of MAGEs ( MAGE-A, -B, and -C subfamilies) fall into the type I classification and are defined as cancer-testis antigens (CTAs) given their (1) restricted expression to testis and other reproductive tissues, (2) aberrant re-activation in cancers, and (3) their ability to elicit an immune response. The remaining ( MAGE-D, -E, -F, -G, -H, NECDIN and MAGEL2 ) are type II MAGEs and have broad expression pattern in many tissues (Figure 1A-B) (2, 3, 5-7). MAGE genes are predominantly assembled on the X chromosome, a characteristic of several CTA gene families.…”
Section: The Mage Familymentioning
confidence: 99%