“…In fact, when LAYN , MAGEH1 , and CCR8 (which represent three of the most enriched genes in tumor-infiltrating Treg cells) are highly detected in whole-tumor samples there is a significant worsening of the 5-year survival of both CRC and NSCLC patients. Although, the functional roles in Treg cells of LAYN, a transmembrane protein with homology to c-type lectin (Borowsky and Hynes, 1998), and of MAGEH1, a member of the melanoma antigen gene family (Weon and Potts, 2015), are unknown, the high expression of the chemokine receptor CCR8 is instead intriguing. Indeed, CCL18, the ligand of CCR8 (Islam et al., 2013), is highly expressed in different tumors including NSCLC (Chen et al., 2011, Schutyser et al., 2005).…”