The magnitude of Yo-Yo test improvements following an aerobic training intervention are associated with total genotype score

Abstract

Recent research has demonstrated that there is considerable inter-individual variation in the response to aerobic training, and that this variation is partially mediated by genetic factors. As such, we aimed to investigate if a genetic based algorithm successfully predicted the magnitude of improvements following eight-weeks of aerobic training in youth soccer players. A genetic test was utilised to examine five single nucleotide polymorphisms (VEGF rs2010963, ADRB2 rs1042713 and rs1042714, CRP rs1205 & PPARGC1A rs8192678), whose occurrence is believed to impact aerobic training adaptations. 42 male soccer players (17.0 ± 1y, 176 ± 6 cm, 69 ± 9 kg) were tested and stratified into three different Total Genotype Score groups; “low”, “medium”and “high”, based on the possession of favourable polymorphisms. Subjects underwent two Yo-Yo tests separated by eight-weeks of sports-specific aerobic training. Overall, there were no significant differences between the genotype groups in pre-training Yo-Yo performance, but evident between-group response differentials emerged in post-training Yo-Yo test performance. Subjects in the “high” group saw much larger improvements (58%) than those in the ‘medium” (35%) and “low” (7%) groups. There were significant (p<0.05) differences between the groups in the magnitude of improvement, with athletes in the “high” and medium group having larger improvements than the “low” group (d = 2.59 “high” vs “low”; d = 1.32 “medium” vs “low”). In conclusion, the magnitude of improvements in aerobic fitness following a training intervention were associated with a genetic algorithm comprised of five single nucleotide polymorphisms. This information could lead to the development of more individualised aerobic training designs, targeting optimal fitness adaptations.

CYP1A2 genotype and acute effects of caffeine on resistance exercise, jumping, and sprinting performance

“…The participants underwent genetic testing using a commercially available testing kit from DNAfit Life Sciences (London, UK), as in other studies [25]. Samples were collected using buccal swab devices, with OCR-100 kits by DNAGenotek (Ottawa, Canada).…”

ADORA2A C Allele Carriers Exhibit Ergogenic Responses to Caffeine Supplementation

“…Genetic testing was performed using a commercially available testing kit from DNAfit Life Sciences. The procedure used for genetic testing is explained in detail elsewhere [33]. Briefly, the buccal swab sample was collected using OCR-100 kits by DNAGenotek.…”

A Review of the Role of the Gut Microbiome in Personalized Sports Nutrition

“…Variability in the physiological response to training and nutrition has been attributed to factors such as age, sex, training history, initial training status, psychological factors, and the mode, duration, intensity, and frequency of training (26). Genetics has also become a large topic of research in the area of variability in response to exercise training and potentially ergogenic dietary components (27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38). It is possible that variability in the gut microbiome may also influence gains in performance in response to training and nutrition.…”