The mammalian amiloride‐insensitive non‐specific salt taste receptor is a vanilloid receptor‐1 variant

Lyall, Vijay; Heck, Gerard L.; Vinnikova, Anna K.; Ghosh, Shobha; Phan, Tam-Hao T.; Alam, Rammy I.; Russell, Oneal F.; Malik, Shahbaz A.; Bigbee, John W.; DeSimone, John A.

doi:10.1113/jphysiol.2004.065656

Cited by 243 publications

(352 citation statements)

References 33 publications

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“…In the urinary bladder, TRPV1 channels are present in both sensory nerves and the bladder epithelium, in which they contribute to voiding behavior (Birder et al, 2001(Birder et al, , 2002. Interestingly, in the tongue, TRPV1-positive fibers innervate the taste papillae (Ishida et al, 2002;Kido et al, 2003), and amiloride-insensitive salt responses in the chorda tympani are abolished in TRPV1-null animals (Lyall et al, 2004). Thus, TRPV1 or a splice variant may transduce some forms of salt taste perception.…”

Section: Trpv1 May Transduce Nociceptive Responses To Elevated Ionicmentioning

confidence: 99%

Extracellular Cations Sensitize and Gate Capsaicin Receptor TRPV1 Modulating Pain Signaling

Ahern¹,

Brooks²,

Miyares³

et al. 2005

J. Neurosci.

164

145

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Transient receptor potential (TRP) channels detect diverse sensory stimuli, including alterations in osmolarity. However, a molecular detector of noxious hypertonic stimuli has not yet been identified. We show here that acute pain-related behavior evoked by elevated ionic strength is abolished in TRP vanilloid subtype 1 (TRPV1)-null mice and inhibited by iodoresiniferatoxin, a potent TRPV1 antagonist. Electrophysiological recordings demonstrate a novel form of ion channel modulation by which extracellular Na ϩ , Mg 2ϩ , and Ca 2ϩ ions sensitize and activate the capsaicin receptor, TRPV1. At room temperature, increasing extracellular Mg 2ϩ (from 1 to 5 mM) or Na ϩ (ϩ50 mM) increased ligand-activated currents up to fourfold, and 10 mM Mg 2ϩ reduced the EC 50 for activation by capsaicin from 890 to 450 nM. Moreover, concentrations of divalent cations Ͼ10 mM directly gate the receptor. These effects occur via electrostatic interactions with two glutamates (E600 and E648) formerly identified as proton-binding residues. Furthermore, phospholipase C-mediated signaling enhances the effects of cations, and physiological concentrations of cations contribute to the bradykinin-evoked activation of TRPV1 and the sensitization of the receptor to heat. Thus, the modulation of TRPV1 by cationic strength may contribute to inflammatory pain signaling.

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Section: Trpv1 May Transduce Nociceptive Responses To Elevated Ionicmentioning

confidence: 99%

Extracellular Cations Sensitize and Gate Capsaicin Receptor TRPV1 Modulating Pain Signaling

Ahern¹,

Brooks²,

Miyares³

et al. 2005

J. Neurosci.

164

145

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“…However, the evidence that this protein is the sole receptor for salt taste is not compelling. A second mechanism that involves the transient receptor potential vanilloid receptor-1 (TRPV1) has been demonstrated for some regions of the tongue using knockout mice (Lyall et al 2004;Ruiz et al 2006). The ENaC receptor is highly selective towards sodium, whereas the TRPV1 receptor is more broadly tuned and is responsible for rejection-responses to K ' , NH 4 ' , and Ca ' salts (DeSimone and Lyall 2006).…”

Section: Taste (Gustation)mentioning

confidence: 99%

Unfolding the codes of short-term feed appetence in farm and companion animals. A comparative oronasal nutrient sensing biology review

Roura¹,

Humphrey²,

Tedó³

et al. 2008

Can. J. Anim. Sci.

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Roura, E., Humphrey, B., Tedo´, G. and Ipharraguerre, I. 2008. Unfolding the codes of short-term feed appetence in farm and companion animals. A comparative oronasal nutrient sensing biology review. Can. J. Anim. Sci. 88: 535Á558. The evolution of the chemical senses has resulted in a sensory apparatus for high taste and smell acuity in mammals and birds to ensure self-nourishment. Such peripheral chemosensory systems function as a code to unfold the nutritional value of feedstuffs. Food ingestion simultaneously evokes odor, taste and thermo-mechanical (somatosensing) sensations. Olfaction represents the capacity to identify feed volatiles that are predominantly derived from essential nutrients in plants.Comparative biology of olfaction shows that primates and chickens have a smaller olfactory epithelium and fewer olfactory receptor (OR) genes than non-primate mammals studied to date including farm and companion animals, such as the pig, the cow, the dog, the cat and the horse. A significant proportion of the total OR genes in mammals and birds have lost their functionality (pseudogenes) in a process that seems to reflect a decrease in the animal's reliance on the sense of smell, particularly in humans and cows. The taste system allows animals to recognize a diverse repertoire of nutrient (sugars, amino acids, salts, acids and fats) or toxic related chemical entities that provide valuable information about the quality of food. Taste senses non-volatile molecules in the oral cavity through taste receptors (TR). The TR are expressed in the sensory cells forming the taste buds of the tongue's papillae. Taste cells are linked to a network of solitary chemosensory cells diffused through many non-taste tissues involved in metabolic homeostasis. The number of functional taste receptor genes (TASR) in humans is equivalent to that in other mammals and superior to that in chickens. The TASR family 1 (TAS1R coding for umami and sweet TR) is conserved, in number and type, across the species evaluated, with the exception of the sweet receptor in chicken and feline species. The TASR family 2 (TAS2R coding for bitter TR) shows a strong adaptive capacity to dietary sources and digestive physiology across vertebrates. Pseudogenization (loss of gene functionality) in the TAS2R family seems to be a frequent strategy. The implications of oronasal nutrient sensing related to comparative animal feeding strategies and behaviors such as neophobia, feed refusal and hedonic preferences are discussed. Feed palatability and appetence might be one of the main driving forces in short-term feed consumption. Finally, practical applications relevant to animal production are outlined.Key words: Nutrient sensing, taste, olfaction, somatosensing, feed intake, farm, companion animals Roura, E., Humphrey, B., Tedo´, G. et Ipharraguerre, I. 2008. Le code de l'appe´tence a`court terme chez les animaux domestiques et de compagnie. Biologie comparative de la de´tection bucco-nasale des e´le´ments nutritifs. Can. J. Anim. Sci. 88: 535Á558. En e´voluant, ...

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“…In rodents and Drosophila, salts are thought to be primarily sensed by cation influx through degenerin/epithelial Na þ channels (DEG/ENaC), leading to membrane depolarisation (Lindemann, 2001;Liu et al, 2003). In humans, the contribution of ENaC channels is less pronounced and salts are thought to be detected by a vanilloid receptor-1 (TRPV1) variant, a member of the transient receptor potential (TRP) cation channel family (Lyall et al, 2004). We use the nematode Caenorhabditis elegans to unravel the molecular mechanisms that mediate the response to NaCl.…”

Section: Introductionmentioning

confidence: 99%

Antagonistic sensory cues generate gustatory plasticity in Caenorhabditis elegans

Hukema

Rademakers

Dekkers

et al. 2006

EMBO J

154

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Caenorhabditis elegans shows chemoattraction to 0.1-200 mM NaCl, avoidance of higher NaCl concentrations, and avoidance of otherwise attractive NaCl concentrations after prolonged exposure to NaCl (gustatory plasticity). Previous studies have shown that the ASE and ASH sensory neurons primarily mediate attraction and avoidance of NaCl, respectively. Here we show that balances between at least four sensory cell types, ASE, ASI, ASH, ADF and perhaps ADL, modulate the response to NaCl. Our results suggest that two NaCl-attraction signalling pathways exist, one of which uses Ca 2 þ /cGMP signalling. In addition, we provide evidence that attraction to NaCl is antagonised by G-protein signalling in the ASH neurons, which is desensitised by the G-protein-coupled receptor kinase GRK-2. Finally, the response to NaCl is modulated by G-protein signalling in the ASI and ADF neurons, a second G-protein pathway in ASH and cGMP signalling in neurons exposed to the body fluid.

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The mammalian amiloride‐insensitive non‐specific salt taste receptor is a vanilloid receptor‐1 variant

Cited by 243 publications

References 33 publications

Extracellular Cations Sensitize and Gate Capsaicin Receptor TRPV1 Modulating Pain Signaling

Extracellular Cations Sensitize and Gate Capsaicin Receptor TRPV1 Modulating Pain Signaling

Unfolding the codes of short-term feed appetence in farm and companion animals. A comparative oronasal nutrient sensing biology review

Antagonistic sensory cues generate gustatory plasticity in Caenorhabditis elegans

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