“…Pioneering studies defined three core complexes based on the discovery of protein interactions or localization: the PAR complex consisting of PAR3, PAR6, and aPKC proteins (Joberty et al, 2000;Lin et al, 2000), the Crumbs complex consisting of CRUMBS, PALS1, and PATJ (Bhat et al, 1999;Makarova et al, 2003;Roh, Makarova, et al, 2002), and the Scribble complex consisting of Scrib, Lgl, and Dlg (Bilder et al, 2000). However, this view became more complex over the years as many interactions between proteins of different complexes can occur (Assémat et al, 2008;Hurd et al, 2003;Lemmers et al, 2004), and interactions of polarity proteins with cytoskeleton regulators and lateral junction proteins are common (Assémat et al, 2008;Chen & Macara, 2005;Itoh et al, 2001;Médina et al, 2002;Michel et al, 2005;Takekuni et al, 2003;Tan et al, 2020). A current limitation in the understanding of polarization is that there is no clear hierarchy in the importance of these numerous interactions.…”