The mammalian sympathetic prevertebral ganglia: Models for the study of neuronal networks and basic neuronal properties

Fasano, Caroline; Niel, Jean-Pierre

doi:10.1016/j.autneu.2009.06.006

Cited by 9 publications

(11 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Recent work has also highlighted the importance of the celiac ganglion in circuitry that modulates the immune system through its noradrenergic projections to the spleen (Andersson & Tracey, ; Bellinger & Lorton, ; Hoover, ). While it is recognized that prevertebral ganglia are complex integrative centers (Fasano & Niel, ; Miolan & Niel, ), our knowledge regarding the neurochemical anatomy of mouse celiac ganglion was sparse. Our findings address this gap by providing a detailed characterization of the neurochemical phenotype of the principal neurons and identifying novel inputs to the ganglion.…”

Section: Discussionmentioning

confidence: 99%

“…While it is recognized that prevertebral ganglia are complex integrative centers (Fasano & Niel, 2009;Miolan & Niel, 1996), our knowledge regarding the neurochemical anatomy of mouse celiac ganglion was sparse. Our findings address this gap by providing a detailed characterization of the neurochemical phenotype of the principal neurons and identifying novel inputs to the ganglion.…”

Section: Discussionmentioning

confidence: 99%

“…Tracer studies have identified projections from postganglionic neurons in the celiac ganglion to the stomach and intestines (Trudrung, Furness, Pompolo, & Messenger, 1994), kidneys (Barajas, Liu, & Powers, 1992) and spleen (Bellinger, Felten, Lorton, & Felten, 1989;Trudrung et al, 1994). Interconnections of the celiac ganglion and other prevertebral ganglia with the gastrointestinal tract have been studied in great detail, leading to the identification of local circuits with welldefined functions and neurochemical anatomy (Fasano & Niel, 2009;Miolan & Niel, 1996). Intestinofugal neurons in the myenteric plexus, which are activated by distension of the gut or other stimuli, provide afferent excitatory input to distinct populations of neurons in specific prevertebral ganglia (Fasano & Niel, 2009;Miolan & Niel, 1996).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Immunohistochemical analysis of the mouse celiac ganglion: An integrative relay station of the peripheral nervous system

Kaestner¹,

Smith²,

Peirce³

et al. 2019

J of Comparative Neurology

View full text Add to dashboard Cite

Celiac ganglia are important sites of signal integration and transduction. Their complex neurochemical anatomy has been studied extensively in guinea pigs but not in mice. The goal of this study was to provide detailed neurochemical characterization of mouse celiac ganglia and noradrenergic nerves in two target tissues, spleen and stomach. A vast majority of mouse celiac neurons express a noradrenergic phenotype, which includes tyrosine hydroxylase (TH), vesicular monoamine transporter 2, and the norepinephrine transporter. Over 80% of these neuron also express neuropeptide Y (NPY), and this coexpression is maintained by dissociated neurons in culture. Likewise, TH and NPY were colocalized in noradrenergic nerves throughout the spleen and in stomach blood vessels. Somatostatin was not detected in principal neurons but did occur in small, TH‐negative cells presumed to be interneurons and in a few varicose nerve fibers. Cholinergic nerves provided the most abundant input to the ganglia, and small percentages of these also contained nitric oxide synthase or vasoactive intestinal polypeptide. A low‐to‐moderate density of nerves also stained separately for the latter markers. Additionally, nerve bundles and varicose nerve fibers containing the sensory neuropeptides, calcitonin gene‐related polypeptide, and substance P, occurred at variable density throughout the ganglia. Collectively, these findings demonstrate that principal neurons of mouse celiac ganglia have less neurochemical diversity than reported for guinea pig and other species but receive input from nerves expressing an array of neurochemical markers. This profile suggests celiac neurons integrate input from many sources to influence target tissues by releasing primarily norepinephrine and NPY.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Immunohistochemical analysis of the mouse celiac ganglion: An integrative relay station of the peripheral nervous system

Kaestner¹,

Smith²,

Peirce³

et al. 2019

J of Comparative Neurology

View full text Add to dashboard Cite

show abstract

“…It appears to be an important signaling molecule in the vascular system and the nervous system, as well as the immune system (Fasano and Niel, 2009;Kanwar et al, 2009). Unlike cyclic nucleotides, however, NO is a gas, is degraded rapidly, and is inactivated by hemoglobin.…”

Section: Nitric Oxide and Cgmp Signalingmentioning

confidence: 99%

Receptor signaling and the cell biology of synaptic transmission

Rasenick

2012

Neurobiology of Psychiatric Disorders

View full text Add to dashboard Cite

“…Sympathetic ganglia are essential elements for the transmission of control signals from the central nervous system (CNS) to numerous target organs (Klimaschewski et al, 1996;McLachlan, 2003;Szurszewski and Miller, 2006;Fasano and Niel, 2009). Neurons in these ganglia receive inputs from preganglionic neurons in the spinal cord, dorsal root ganglia neurons and visceral organs such as the gastrointestinal tract and genitourinary systems.…”

Section: Introductionmentioning

confidence: 99%

Peripheral inflammation augments gap junction-mediated coupling among satellite glial cells in mouse sympathetic ganglia

2010

View full text Add to dashboard Cite

Intercellular coupling by gap junctions is one of the main features of glial cells, but very little is known about this aspect of satellite glial cells (SGCs) in sympathetic ganglia. We used the dye coupling method to address this question in both a prevertebral ganglion (superior mesenteric) and a paravertebral ganglion (superior cervical) of mice. We found that in control ganglia, the incidence of dye coupling among SGCs that form the envelope around a given neuron was 10-20%, and coupling between SGCs around different envelopes was rare (1.5-3%). The dye injections also provided novel information on the structure of SGCs. Following peripheral inflammation, both types of coupling were increased, but most striking was the augmentation of coupling between SGCs forming envelopes around different neurons, which rose by 8-14.6-fold. This effect appeared to be non-systemic, and was blocked by the gap junction blocker carbenoxolone. These changes in SGCs may affect signal transmission and processing in sympathetic ganglia.

show abstract

The mammalian sympathetic prevertebral ganglia: Models for the study of neuronal networks and basic neuronal properties

Cited by 9 publications

References 61 publications

Immunohistochemical analysis of the mouse celiac ganglion: An integrative relay station of the peripheral nervous system

Immunohistochemical analysis of the mouse celiac ganglion: An integrative relay station of the peripheral nervous system

Receptor signaling and the cell biology of synaptic transmission

Peripheral inflammation augments gap junction-mediated coupling among satellite glial cells in mouse sympathetic ganglia

Contact Info

Product

Resources

About