The management of acute severe asthma

Tatham, M. E.; Gellert, A R

doi:10.1136/pgmj.61.717.599

Cited by 5 publications

(3 citation statements)

References 55 publications

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“…The correction of this parameter in se vere acute asthma is controversial. Responsiveness to Pa-agonists may be improved after pH correction [10], but this finding was not confirmed in other studies [18].…”

Section: Supportive Treatmentmentioning

confidence: 77%

Severe Acute Asthma

Solèr

Imhof

Ap³

1990

Respiration

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Bronchial asthma is characterized as a disease with recurrent, reversible, and generalized airway obstruction and an increased airway responsiveness to nonspecific stimuli. Besides symptoms of airway hyperresponsiveness, episodic asthmatic attacks, and chronic airway obstruction, severe acute asthma, or ‘status asthmaticus’, is an important and life-threatening manifestation of the disease. This paper gives an overview of the pathophysiology, clinical risk assessment, and treatment of severe acute asthma

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Section: Supportive Treatmentmentioning

confidence: 77%

Severe Acute Asthma

Solèr

Imhof

Ap³

1990

Respiration

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“…The standardized death rate from asthma in the 5-34 year age group has remained constant in the last century despite improved pharmacological treatment (Tatham & Gellert, 1985). The conventional management of acute severe asthma comprises the administration of oxygen, bronchodilators by inhalation and injection, corticosteroids Failed resuscitation in acute severe asthma 235 and antibiotics.…”

Section: Discussionmentioning

confidence: 99%

Failed resuscitation in acute severe asthma: a medical indication for emergency thoracotomy?

Diament

Sloan²

1987

Emergency Medicine Journal

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“…[78,79] Factors that may impair aerosol delivery include limitations of air flow resulting from bronchoconstriction, inflammation and oedema of the airways, decreased patient cooperation and unusual breathing patterns. These factors result in a decreased dose-response curve and duration of activity for these agents.…”

Section: Therapeutic Guidelinesmentioning

confidence: 99%

Drug Therapy Approaches in the Treatment of Acute Severe Asthma in Hospitalised Children

2001

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Acute severe paediatric asthma remains a serious and debilitating disease throughout the world. The incidence and mortality from asthma continue to increase. Early, effective and aggressive outpatient therapy is essential in reducing symptoms and preventing life-threatening progression. When complications occur or when the disease progresses to incipient respiratory failure, these children need to be managed in a continuous care facility where aggressive and potentially dangerous interventions can be safely instituted to reverse persistent bronchospasm. The primary drugs for acute severe asthma include oxygen, corticosteroids, salbutamol (albuterol) and anticholinergics. Second-line drugs include heliox, magnesium sulfate, ketamine and inhalational anaesthetics. Future therapies may include furosemide, leukotriene modifiers, antihistamines and phosphodiesterase inhibitors. This review attempts to explore the multitude of medications available with emphasis on pharmacology and pathophysiology.

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The management of acute severe asthma

Cited by 5 publications

References 55 publications

Severe Acute Asthma

Severe Acute Asthma

Failed resuscitation in acute severe asthma: a medical indication for emergency thoracotomy?

Drug Therapy Approaches in the Treatment of Acute Severe Asthma in Hospitalised Children

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