Background: Acne vulgaris is a common chronic skin disease involving blockage and/or inflammation of pilosebaceous units (hair follicles and their accompanying sebaceous gland). Acne can present -non-inflammatory lesions (open and closed comedones), inflammatory lesions (papules, pustules, and nodules), and varying degrees of scarring or a mixture of both, affecting mostly the face but also the back and chest. Acne leads to significant morbidity that is associated with residual scarring and psychological disturbances such as poor self-image, depression, and anxiety, which leads to a negative impact on quality of life. Subjects and Methods: Total 200 patients divided into two groups of 100 each. One group was treated with dermaroller every four weeks for a period of 24 weeks and the other group was treated with fractional CO2 laser again every four weeks for a period of 24 weeks. Results: Six patients in dermaroller and nine patients in fractional CO2 laser group developed hyperpigmentation post procedure. Conclusion: Itching is not seen as a complication in the treatment with derma-roller, but in case of fractional CO2 laser group, a very small percentage of patients experienced itching a few days after the treatment due to peeling off of the scab that was formed after treatment.