The Management of Idiopathic and Refractory Syringomyelia

Gallo, Pasquale; Kaliaperumal, Chandrasekaran

doi:10.1007/978-3-030-99166-1_10

Cited by 3 publications

(2 citation statements)

References 56 publications

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“…Eligible participants for this study were required to (1) have syringomyelia or a condition predisposing them to syringomyelia formation, such as Chiari I malformation, (2) be 18 years of age or older, and (3) be able to give informed consent. For patients to be eligible for surgery, they were required to (1) have new or increased impairment in sensation, strength, or walking within the previous 2 years, (2) have an MRI scan showing a syrinx corresponding to a part of the spinal cord that could produce their symptoms, and (3) be in sufficient health to withstand a major surgical procedure and remain active during the recovery period. Participants were excluded from the study if they were pregnant, could not have an MRI scan as determined by the radiologist, or had a bleeding problem that could not be corrected.…”

Section: Recruitment and Study Designmentioning

confidence: 99%

“…Syringomyelia is most associated with Chiari I malformation [1]. However, it may also accompany other conditions obstructing cerebrospinal fluid (CSF) flow, including degenerative spinal disorders, arachnoiditis, and other craniovertebral junction abnormalities like basilar invagination [2]. Patients with Chiari I malformation and syringomyelia suffer neurological symptoms like headaches, poor balance, upper extremity weakness, numbness, loss of sensation, and pain.…”

Section: Introductionmentioning

confidence: 99%

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Developing Semiautomated Methods to Measure Pre- and Postoperative Syrinx Volumes

Kohut,

Graff,

Wakelin

et al. 2023

JCM

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Neurosurgeons evaluate MRI scans to document whether surgical treatment has reduced syrinx size. Manual measurement of syrinx volume is time-consuming and potentially introduces operator error and bias. Developing convenient semiautomated volumetric analysis methods may encourage their clinical implementation and improve syringomyelia monitoring. We analyzed 30 SPGR axial MRI scans from 15 pre- and postoperative Chiari I and syringomyelia patients using two semiautomated (SCAT and 3DQI) methods and a manual Cavalieri (CAV) method. Patients’ spinal cord and syrinx volumes pre- and postoperatively were compared by paired t-test. A decrease in syrinx volume (mm3) after surgery was detected across all methods. Mean syrinx volume (± SD) measured by CAV (n = 30) was, preoperatively, 4515 mm3 ± 3720, postoperatively 1109 ± 1469; (p = 0.0004). SCAT was, pre, 4584 ± 3826, post, 1064 ± 1465; (p = 0.0007) and 3DQI was, pre, 4027 ± 3805, post, 819 ± 1242; (p = 0.001). 3DQI and CAV detected similar mean spinal cord volumes before (p = 0.53) and after surgery (p = 0.23), but SCAT volumes differed significantly (p = 0.005, p = 0.0001). The SCAT and 3DQI semiautomated methods recorded surgically related syrinx volume changes efficiently and with enough accuracy for clinical decision-making and research studies.

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Section: Recruitment and Study Designmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%